OPTIMIZATION OF FORMULATION OF SOLID DISPERSION OF FUROSEMIDE BY FACTORIAL DESIGN

Objective: The present study aimed to improve the rate of dissolution of furosemide by solid dispersion technique. Methods: Solid dispersion of furosemide was prepared by using hydrogel isolated from the seeds of Lepidium sativum as a novel carrier by the solvent evaporation method. Solid dispersion was evaluated to study the improvement in the rate of dissolution. Molecular dispersion of furosemide in the novel carrier was studied by DSC and FTIR studies. Solid dispersion was filled in capsules after stability studies and the formulation was optimized by adopting factorial design. Results: Solid dispersion of furosemide exhibited dissolution improvement from 13.54 % (plain furosemide) to 69.12% (solid dispersion) in the first 60 min. Improvement in dissolution efficiency was found to be retained after stability studies. Capsules were filled with the formulation of solid dispersion using two different grades of lactose-α lactose monohydrate and anhydrous lactose and were found stable after stabilization studies. Conclusion: The dissolution improvement of furosemide was attributed to its molecular dispersion in the novel carrier selected for this study. The recrystallization of furosemide was prevented due to intermolecular interaction between the novel carrier and furosemide. This was confirmed by FTIR. Evaluation of the dissolution data of factorial batches was analyzed by ANOVA. Analysis of the data revealed that selected levels of α lactose monohydrate and anhydrous lactose would be useful to navigate design space.

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Release mechanism based on polymer-drug dissolution and stability studies of paracetamol solid dispersion

10.3390/ecps2012-00802 ◽

2012 ◽

Author(s):

Afzal Mohammed ◽

Sheraz Khan ◽

Hannah Batchelor ◽

Yvonne Perrie

Keyword(s):

Solid Dispersion ◽

Drug Dissolution ◽

Release Mechanism ◽

Stability Studies

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Study of Dissolution Enhancement of Furosemide by Solid Dispersion Technique Using Different Polymer

Journal of Pharmacy and Nutrition Sciences ◽

10.29169/1927-5951.2019.09.06.6 ◽

2019 ◽

Vol 9 (6) ◽

pp. 329-338

Author(s):

Md. Didaruzzaman Sohel3 ◽

Keyword(s):

Solid Dispersion ◽

Dissolution Enhancement ◽

Dispersion Technique

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Solubility Enhancement of Canagliflozin by Binary and Ternary Solid Dispersion Technique

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.03.103 ◽

2020 ◽

Vol 12 (03) ◽

Keyword(s):

Solid Dispersion ◽

Solubility Enhancement ◽

Ternary Solid Dispersion ◽

Dispersion Technique

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Formulation and Evaluation of Nanosuspension of Simvastatin

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2015.8.2.9 ◽

2015 ◽

Vol 8 (2) ◽

pp. 2858-2873

Author(s):

Rupali L. Shid ◽

Shashikant N. Dhole ◽

Nilesh Kulkarni ◽

Santosh L Shid

Keyword(s):

Particle Size ◽

Zeta Potential ◽

Factorial Design ◽

Dissolution Rate ◽

In Vitro Dissolution ◽

Total Drug ◽

23 Factorial Design ◽

Rate Of Dissolution

Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of this study wasto increase the solubility and dissolution rate of simvastatin by the preparation of nanosuspension by emulsification solvent diffusion method at laboratory scale. Prepared nanosus-pension was evaluated for its particle size and in vitro dissolution study and characterized by zeta potential,differential scanning calorimetry (DSC) and X-Ray diffractometry (XRD), motic digital microscopy, entrapment efficiency, total drug content, saturated solubility study and in vivo study. A 23 factorial design was employed to study the effect of independent variables, amount of SLS (X1), amount of PVPK-30 (X2) and poloxamer-188 (X3) and dependent variables are total drug content and polydispersity Index. The obtained results showed that particle size (nm) and rate of dissolution has been improved when nanosuspension prepared with the higherconcentration of PVPK-30 with the higher concentration of PVP K-30 and Poloxamer-188 and lower concentration of SLS. The particle size and zeta potential of optimized formulation was found to be 258.3 nm and 23.43. The rate of dissolution of the optimized nanosuspension was enhanced (90% in 60min), relative to plain simvastatin (21% in 60 min), mainly due to the formation of nanosized particles. These results indicate the suitability of 23 factorial design for preparation of simvastatin loaded nano-suspension significantly improved in vitro dissolution rate and thus possibly enhance fast onset of therapeutic drug effect. In vivo study shows increase in bioavailability in nanosuspension formulation than the plain simvastatin drug.

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