Improvement of dissolution rate of tacrolimus by solid dispersion technique

2013 ◽  
Vol 43 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Pranav V. Patel ◽  
Shital S. Panchal ◽  
Tejal A. Mehta
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Dispersion Technique

scholarly journals Enhancement of Solubility and Dissolution Rate of Indomethacin by Chitosan Based Solid Dispersion Technique.

2015 ◽  
Vol 5 (2) ◽  
pp. 1463-1472 ◽  
Author(s):  
Shete A.S . ◽  
Yadav V.B . ◽  
Sakhare S.S . ◽  
Patil S.B . ◽  
Sajane S.J . ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Dispersion Technique

scholarly journals Solid Dispersions : An Approach to Enhance the Bioavailability of Poorly Water-Soluble Drugs

2013 ◽  
pp. 37-46
Author(s):  
Sanjoy Kumar Das
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Historical Background ◽  
Solid Dosage ◽  
Advantages And Disadvantages ◽  
Water Soluble Drugs ◽  
Inert Carrier ◽  
Dispersion Technique

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. This article reviews historical background of solid dispersion technology, limitations, classification, and various preparation techniques with its advantages and disadvantages. This review also discusses the recent advances in the field of solid dispersion technology. Based on the existing results and authors’ reflection, this review give rise to reasoning and suggested choices of carrier or matrix and solid dispersion procedure.

scholarly journals Enhancing dissolution profile of diazepam using hydrophilic polymers by solid dispersion technique

2012 ◽  
Vol 1 (12) ◽  
pp. 423-430 ◽  
Author(s):  
Md. Sariful Islam Howlader ◽  
Jayanta Kishor Chakrabarty ◽  
Khandokar Sadique Faisal ◽  
Uttom Kumar ◽  
Md. Raihan Sarkar ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Distilled Water ◽  
Dissolution Profile ◽  
Peg 6000 ◽  
Solvent Method ◽  
Pure Drug ◽  
Dispersion Technique

The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Diazepam was used as a model drug to evaluate its release characteristics from different matrices. Solid dispersions were prepared by using polyethylene glycol 6000 (PEG-6000), HPMC, HPC and Poloxamer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solid dispersions were prepared by solvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was used as dissolution medium in each dissolution basket at a temperature of 37°C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pure Diazepam and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. SEM (Scanning Electron microscope) studies shows that the solid dispersion having a uniform dispersion. Solid dispersions prepared with PEG-6000, Poloxamer showed the highest improvement in wettability and dissolution rate of Diazepam. Solid dispersion containing polymer prepared with solvent method showed significant improvement in the release profile as compared to pure drug, Diazepam.DOI: http://dx.doi.org/10.3329/icpj.v1i12.12453 International Current Pharmaceutical Journal 2012, 1(12): 423-430

Improvement of dissolution rate of aceclofenac by solid dispersion technique

2011 ◽  
Vol 207 (1-3) ◽  
pp. 47-54 ◽  
Author(s):  
Furqan A. Maulvi ◽  
Sonali J. Dalwadi ◽  
Vaishali T. Thakkar ◽  
Tejal G. Soni ◽  
Mukesh C. Gohel ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Dispersion Technique

Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique

1999 ◽  
Vol 187 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Jae-Young Jung ◽  
Sun Dong Yoo ◽  
Sang-Heon Lee ◽  
Kye-Hyun Kim ◽  
Doo-Sun Yoon ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Enhanced Solubility ◽  
Dispersion Technique

scholarly journals Heightening the solubility of poorly soluble fenofibrate by Solid Dispersion Technique

2020 ◽  
Vol 11 (1) ◽  
pp. 663-668
Author(s):  
Yasmin Begum M ◽  
Prathyusha Reddy G
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Aqueous Solubility ◽  
Gastric Fluid ◽  
Lipid Lowering ◽  
Solid Inclusion ◽  
Gastrointestinal Fluid ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Lowering Drug

The intention of the current study was to boost the solubility of Fenofibrate by solid dispersion technique which is an efficient technique in improving the solubility and hence the dissolution rate of poorly soluble drugs in the form of eutectic mixtures by producing fine dispersion when in contact with gastrointestinal fluid and also the technique offers the choices of carriers to be combined with drug conveniently to improve the solubility to a considerable extent. Fenofibrate a BCS class II Antihyperlipidemic drug belongs to fibrate class and it is a lipid-lowering drug used in the treatment of hyperlipidemia. Fenofibrate is insoluble in water and hence shows poor dissolution in gastric fluid with reduced absorption characteristics. In order to improve the solubility, dissolution rate, gastrointestinal absorption and oral bioavailability, it was decided to prepare fenofibrate solid dispersion and evaluated. They were prepared using poly ethylene glycol 4000, 6000, 8000 and β-cyclodextrin by fusion technique and optimized solid dispersion was also lyophilized. Physical characterization of solid inclusion complex of fenofibrate was studied and showed that there were no drug excipients interactions. Dissolution studies showed a momentous rise in a dissolution of Fenofibrate when dispersed in polymers. Inturn aqueous solubility was enlarged linearly as a function of the concentration of β- Cyclodextrin.

Dissolution Rate Enhancement of Ramipril by Solid Dispersion Technique

2020 ◽  
Vol 10 (1) ◽  
pp. 08
Author(s):  
Rohan R. Vakhariya ◽  
S. M. Kumbhar ◽  
R. B. lade ◽  
P. S. Salunkhe ◽  
R. H. Ubale
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Rate Enhancement ◽  
Dissolution Rate Enhancement ◽  
Dispersion Technique
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