Companion diagnostics at the intersection of personalized medicine and healthcare delivery

<p>Companion diagnostics (CDx) represent a new frontier in personalized medicine that promises to improve treatment outcomes by matching therapies to patients. Currently, these tests are limited in scope and cannot report on real-time changes associated with disease progression and remediation. To address this, we have developed the first photoacoustic imaging-based CDx (PACDx) for the selective detection of elevated glutathione (GSH) in lung cancer. Since GSH is abundant in most cells, we utilized a physical organic approach to precisely tune the chemical reactivity to distinguish between normal and pathological states. In blinded studies, PACDx was applied to identify mice bearing lung tumors. Moreover, we designed a matching prodrug, PARx, that utilizes the same mechanism to release a chemotherapeutic with a PA readout. We demonstrate that PARx can inhibit tumor growth without off-target toxicity in a lung cancer xenograft model. We envision that this work will establish a new standard for personalized medicine by employing a unique imaging-based approach.<br></p>

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3D Printing in Healthcare

Research Anthology on Emerging Technologies and Ethical Implications in Human Enhancement ◽

10.4018/978-1-7998-8050-9.ch035 ◽

2021 ◽

pp. 696-703

Author(s):

Nilmini Wickramasinghe

Keyword(s):

3D Printing ◽

Personalized Medicine ◽

Healthcare Delivery ◽

Healthcare Sector ◽

Disruptive Technology ◽

3D Printed ◽

Average User ◽

The Way ◽

Aerospace And Defense

3D printing has developed as a modification of an old injection printer. Today, it is rapidly expanding offering novel possibilities as well as new exciting applications for various sectors including healthcare, automotive, aerospace, and defense industries. This chapter presents key application areas within the healthcare sector. In medicine, 3D printing is revolutionizing the way operations are carried out, disrupting prosthesis and implant markets as well as dentistry. The relatively new field of bioprinting has come to be because of advances with this technology. As will be discussed, numerous applications of 3D printing in healthcare relate to personalized medicine. For instance, implants or prostheses are 3D printed for a specific user's body, optimizing the technology to work for an individual, not an average user as with most mass-produced products. In addition, 3D printing has applications on the nanoscale with printing of drugs and other smaller items. Hence, 3D printing represents a disruptive technology for healthcare delivery.

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The Canadian Path from Discovery to Implementation of Personalized Medicine Approaches

Biomedicine Hub ◽

10.1159/000479487 ◽

2017 ◽

Vol 2 (Suppl. 1) ◽

pp. 1-3

Author(s):

Étienne Richer ◽

Rachel Syme ◽

Stephen M. Robbins ◽

Paul Lasko

Keyword(s):

Personalized Medicine ◽

Precision Medicine ◽

Health Research ◽

New Technologies ◽

Healthcare Delivery ◽

Data Sources ◽

Future Developments ◽

Success Stories ◽

Canadian Perspective

Personalized (or precision) medicine approaches are currently being introduced in healthcare delivery following the development of new technologies and of novel ways to integrate and analyze various data sources. This editorial describes the efforts invested since 2012 by the Canadian Institutes of Health Research (CIHR) to foster the development and implementation of personalized medicine in Canada. Success stories from past investments as well as future developments are presented from a Canadian perspective.

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