Frequency and prognosis of metastasis to liver, lung, bone and brain from Merkel cell carcinoma

Aim: To describe the factors affecting distant metastasis of Merkel cell carcinoma (MCC) and the prognosis of metastatic MCC. Materials & methods: The MCC patient information was downloaded from the SEER database. Logistic regression and Cox proportional hazard models were conducted to screen for significant factors. Results: A total of 3449 patients were enrolled. Surgery and chemotherapy were significantly correlated with the occurrence of distant metastasis. In the cause-specific survival rate of MCC, regional lymph node removal, sentinel lymph node biopsy, radiation and chemotherapy can significantly reduce the prognostic risk of patients with distant metastases. Conclusion: Our study screened out the factors affecting the distant metastasis and prognosis of MCC and more prospective studies are needed to verify our findings.

Download Full-text

Faculty Opinions recommendation of Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1064845.517780 ◽

2007 ◽

Author(s):

David Slater

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Meta Analysis ◽

Lymph Node Biopsy ◽

Merkel Cell ◽

Node Biopsy

Download Full-text

Faculty Opinions recommendation of Sentinel lymph node biopsy in Merkel cell carcinoma: a 15-year institutional experience and statistical analysis of 721 reported cases.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725857773.793520545 ◽

2016 ◽

Author(s):

Giuseppe Argenziano ◽

Elvira Moscarella

Keyword(s):

Lymph Node ◽

Statistical Analysis ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Lymph Node Biopsy ◽

Merkel Cell ◽

Node Biopsy ◽

Institutional Experience

Download Full-text

Role of Sentinel Lymph Node Biopsy in the Management of Merkel Cell Carcinoma

Journal of Skin Cancer ◽

10.1155/2012/176173 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Eric P. Arruda ◽

Kevin M. Higgins

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Neck Region ◽

Lymph Node Biopsy ◽

Merkel Cell ◽

Treatment Protocols ◽

Node Biopsy

Merkel cell carcinoma (MCC) is a rare and typically aggressive form of skin cancer. It most commonly affects the elderly and has a predilection for the sun-exposed skin of the head and neck region. Other etiological factors include immune suppression, organ transplantation, and polyoma virus infection. MCC has a propensity to spread to regional lymphatics with a high locoregional recurrence rate. Since its discovery in 1972, treatment paradigms have shifted, with no consensus on optimal management strategies. Currently, standard of care includes surgical intervention to the primary and locoregional site with adjuvant radiotherapy for high-risk disease. In this paper, we discuss the history, pathology, and epidemiology of this rare disease with a focus on the evidentiary basis of treatment protocols. The use of sentinel lymph node biopsy as a management option will be the focus of this paper.

Download Full-text