Histopathological and immunohistochemical evaluation of bone marrow biopsy in myelodysplastic syndromes

2013 ◽  
Vol 2 (3) ◽  
pp. 219-228
Author(s):  
Emanuela Boveri ◽  
Giorgio Croci ◽  
Umberto Gianelli ◽  
Marcello Gambacorta ◽  
Giuseppe Isimbaldi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes

Bone Marrow Biopsy in RAEB and RAEB-t Myelodysplastic Syndromes

1992 ◽  
pp. 67-73 ◽  
Author(s):  
G. Lambertenghi-Deliliers ◽  
D. Soligo ◽  
C. Annaloro ◽  
E. Pozzoli ◽  
A. Riva
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes

Histopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy

1987 ◽  
Vol 87 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Francoise Delacrétaz ◽  
Pierre-Michel Schmidt ◽  
Dominique Piguet ◽  
Fedor Bachmann ◽  
Jose Costa
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Fab Classification

Usefulness of Functional Image Analysis Using Positron Emission Tomography for the Discrimination between Hypoplastic Myelodysplastic Syndromes and Aplastic Anemia.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4916-4916
Author(s):  
Masaaki Takatoku ◽  
Toshihiko Sato ◽  
Kaoru Hatano ◽  
Ken Omine ◽  
Masaki Mori ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Bone Marrow ◽  
Aplastic Anemia ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Time Point

Abstract Myelodysplastic syndromes (MDS) and aplastic anemia (AA) are classified bone marrow failure syndromes. Their clinical and pathological features partly overlap. It is sometimes difficult to distinguish hypoplastic MDS from AA by using current common diagnostic methods such as bone marrow biopsy and chromosome analysis. Although magnetic resonance image (MRI) is useful for diagnosis of MDS with hypercellular bone marrow, it is difficult to discriminate between hypoplastic MDS and AA using this method because the high intensity patterns on T1-enhanced images are similar in these disorders. Quantitative imaging with fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has been recognized as a useful examination for discrimination between benign and malignant regions in various conditions. Since the decrease in FDG uptake at the late phase is much slower in a malignant region than in a benign region, dual time point imaging provides more accurate information than does conventional single time point scanning. In this study, we investigated the usefulness of dual time protocol FDG-PET in differential diagnosis of hypoplastic MDS and AA. Seventeen patients (7 with typical MDS (RA), 4 with hypoplastic MDS, 6 with AA) and 30 healthy adults agreed to participate in this study. Bone marrow biopsy, FDG-PET, MRI and CT were carried out. Spine, femur and iliac lesions were detected by their increased FDG uptake at 60 and 120 min after injection of 0.12 mCi/kg of FDG. The mean lesional standardized uptake values (SUVmean) at 60 and 120 min after injection of FDG were determined. While the median SUVmean of normal lumbar regions at 60 min was 1.123 ± 0.219, that of MDS cases was 2.06 (range, 1.62–2.32). At 120 min, the median SUVmean of normal cases was 1.180 ± 0.119, whereas that of MDS cases was 2.44 (range, 2.08–2.98). It is noteworthy that the SUVmean of four hypoplastic MDS cases was also high (ranges: 1.96–2.23 at 60 min and 1.97–2.52 at 120 min), suggesting that bone marrow in hypoplastic MDS has a hyper-metabolic state of glucose like other malignant disorders. We also observed a patchy hot area, which may be a visualization of ineffective hematopoiesis, throughout the spine image of hypoplastic MDS. In contrast, the SUVmeans at both time points of four AA cases were not different from those in normal control cases. These results suggest that functional imaging analysis using an FDG-PET dual time protocol enables discrimination between hypoplastic MDS and AA, in which MR images similar intensities.

scholarly journals Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Jacob D. Kjelland ◽  
Denis M. Dwyre ◽  
Brian A. Jonas
Keyword(s):  
Bone Marrow ◽  
Chest Pain ◽  
Myelodysplastic Syndrome ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Rare Case ◽  
Elderly Male ◽  
Multilineage Dysplasia ◽  
Ring Sideroblasts

Acquired elliptocytosis is a known but rarely described abnormality in the myelodysplastic syndromes (MDS). Here we report the case of an elderly male who was admitted to the hospital with chest pain, dyspnea, and fatigue and was found to be anemic with an elliptocytosis that had only recently been noted on peripheral smears of his blood. After bone marrow biopsy he was diagnosed with MDS with ring sideroblasts and multilineage dysplasia and acquired elliptocytosis. Here we report a rare case of acquired elliptocytosis cooccurring with MDS with ring sideroblasts and multilineage dysplasia.

Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes

1993 ◽  
Vol 66 (2) ◽  
pp. 85-91 ◽  
Author(s):  
G. Lambertenghi-Deliliers ◽  
C. Annaloro ◽  
A. Oriani ◽  
D. Soligo ◽  
E. Pozzoli ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Histological Findings ◽  
Prognostic Relevance

Diagnosis of Myelodysplastic Syndromes without a Bone Marrow Biopsy: A Non-Invasive Diagnostic Model

2017 ◽  
Vol 55 ◽  
pp. S78
Author(s):  
H.S. Oster ◽  
G. Carmi ◽  
A. Kolomansky ◽  
E. Joffe ◽  
I. Kaye ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Diagnostic Model ◽  
Non Invasive

scholarly journals Hypoplastic Myelodysplastic Syndromes Can Be Distinguished From Acquired Aplastic Anemia by CD34 and PCNA Immunostaining of Bone Marrow Biopsy Specimens

1997 ◽  
Vol 107 (3) ◽  
pp. 268-274 ◽  
Author(s):  
Attilio Orazi ◽  
Albitar Maher ◽  
Nyla A. Heerema ◽  
Sharon Haskins ◽  
Richard S. Neiman
Keyword(s):  
Bone Marrow ◽  
Aplastic Anemia ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Biopsy Specimens

scholarly journals QBEND10 for the diagnosis of myelodysplastic syndromes in routinely processed bone marrow biopsy specimens.

1995 ◽  
Vol 48 (4) ◽  
pp. 291-294 ◽  
Author(s):  
H P Horny ◽  
M Wehrmann ◽  
H U Schlicker ◽  
A Eichstaedt ◽  
M R Clemens ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Myelodysplastic Syndromes ◽  
Biopsy Specimens
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