Irreversible hepatotoxicity after administration of trabectedin to a pleiomorphic sarcoma patient with a rareABCC2polymorphism: a case report

2013 ◽  
Vol 14 (12) ◽  
pp. 1389-1396 ◽  
Author(s):  
Anne-Pascale Laurenty ◽  
Fabienne Thomas ◽  
Etienne Chatelut ◽  
Sarah Bétrian ◽  
Chantal Le Guellec ◽  
...  
Keyword(s):  
2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Ela A. Server ◽  
Yusuf M. Durna ◽  
Ozgur Yigit ◽  
Erol R. Bozkurt

This paper presents a case report of an HIV-negative, supraglottic Kaposi’s sarcoma patient. The 80-year-old male patient was admitted with complaints of hoarseness, difficulty in swallowing, and a stinging sensation in his throat for approximately six months. The endoscopic larynx examination revealed a lesion which had completely infiltrated the epiglottis, reached right aryepiglottic fold, was vegetating, pink and purple in color, multilobular, fragile, and shaped like a bunch of grapes, and partially blocked the bleeding airway passage. The case was discussed by the hospital’s head-neck cancer committee and a surgery decision was made. A tracheotomy was performed under local anesthesia before the operation due to respiratory distress and endotracheal intubation difficulty. Direct laryngoscopy showed that the mass was limited in the supraglottic area, had invaded the entire left aryepiglottic fold and one-third of the front right aryepiglottic fold, and completely covered epiglottis. It should be remembered that although rare, Kaposi’s sarcoma may be encountered in larynx malignancy cases. Disease-free survival may be achieved through local excision and postoperative radiotherapy.


2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Mayumi Ishida ◽  
Jungo Imanishi ◽  
Yasuo Yazawa ◽  
Yu Sunakawa ◽  
Tomoaki Torigoe ◽  
...  
Keyword(s):  

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Marcella Tazzari ◽  
Elena Palassini ◽  
Barbara Vergani ◽  
Antonello Villa ◽  
Francesca Rini ◽  
...  

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Heidi M. Namløs ◽  
Olga Zaikova ◽  
Bodil Bjerkehagen ◽  
Daniel Vodák ◽  
Eivind Hovig ◽  
...  

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091059
Author(s):  
Mariangela Gomez ◽  
Kerry Whiting ◽  
Rana Naous

Alveolar soft part sarcoma is a rare malignant soft tissue tumor, mainly localized in the extremities and occurring principally in adolescents and young adults. Alveolar soft part sarcoma are uncommon in the female genital tract. We here report a case of alveolar soft part sarcoma in a 20-year-old nullipara, presenting with vaginal bleeding and profound anemia requiring blood transfusions. Ultrasonographic examination revealed a polyp in the lower uterine segment. Surgical resection of the polyp was performed, and pathological evaluation showed typical histological, immunohistochemical, and molecular features consistent with alveolar soft part sarcoma. Patient underwent for total hysterectomy. Currently, she follows up with her surgeon and has no new complains. Given the infrequency of alveolar soft part sarcoma, this case report raises the awareness of alveolar soft part sarcoma as one of the entities to consider when confronted with a uterine polyp in a young patient.


2018 ◽  
Vol 05 (06) ◽  
pp. 447-449
Author(s):  
Kakoti Lopa Mudra ◽  
Choudhury Zachariya ◽  
Sharma Jagannath

Author(s):  
Narinder Singh ◽  
Vipin Sharma ◽  
Rahul Bharadwaj ◽  
Kavya Sharma

<p>We report herein, a rare case of a 14-year-old child with alveolar soft part sarcoma. The patient initially noticed a progressively growing mass over medial side of right distal thigh. Although clinically the swelling appeared to be lipoma, the needle biopsy confirmed it to be alveolar soft part sarcoma. Patient was managed by wide excision, followed by adjuvant chemotherapy.</p>


2020 ◽  
Vol 29 (4) ◽  
pp. 685-690
Author(s):  
C. S. Vanaja ◽  
Miriam Soni Abigail

Purpose Misophonia is a sound tolerance disorder condition in certain sounds that trigger intense emotional or physiological responses. While some persons may experience misophonia, a few patients suffer from misophonia. However, there is a dearth of literature on audiological assessment and management of persons with misophonia. The purpose of this report is to discuss the assessment of misophonia and highlight the management option that helped a patient with misophonia. Method A case study of a 26-year-old woman with the complaint of decreased tolerance to specific sounds affecting quality of life is reported. Audiological assessment differentiated misophonia from hyperacusis. Management included retraining counseling as well as desensitization and habituation therapy based on the principles described by P. J. Jastreboff and Jastreboff (2014). A misophonia questionnaire was administered at regular intervals to monitor the effectiveness of therapy. Results A detailed case history and audiological evaluations including pure-tone audiogram and Johnson Hyperacusis Index revealed the presence of misophonia. The patient benefitted from intervention, and the scores of the misophonia questionnaire indicated a decrease in the severity of the problem. Conclusions It is important to differentially diagnose misophonia and hyperacusis in persons with sound tolerance disorders. Retraining counseling as well as desensitization and habituation therapy can help patients who suffer from misophonia.


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