scholarly journals Bradykinin receptors in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Joseph Coulson ◽  
Réjean Couture ◽  
Alexander Faussner ◽  
Fernand Gobeil Jr ◽  
Fredrik Leeb-Lundberg ◽  
...  
Keyword(s):  
North America ◽  
Hereditary Angioedema ◽  
Bradykinin Receptors ◽  
Receptor Antagonists ◽  
Endogenous Peptides ◽  
Kinin Receptors ◽  
Acute Attacks

Bradykinin (or kinin) receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Bradykinin (kinin) Receptors [91]) are activated by the endogenous peptides bradykinin (BK), [des-Arg9]bradykinin, Lys-BK (kallidin), [des-Arg10]kallidin, [Phospho-Ser6]-Bradykinin, T-kinin (Ile-Ser-BK), [Hyp3]bradykinin and Lys-[Hyp3]-bradykinin. Variation in pharmacology and activity of B1 and B2 receptor antagonists at species orthologs has been documented. icatibant (Hoe140, Firazir) is approved in North America and Europe for the treatment of acute attacks of hereditary angioedema.

scholarly journals Bradykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Joseph Coulson ◽  
Réjean Couture ◽  
Alexander Faussner ◽  
Fernand Gobeil Jr ◽  
Fredrik Leeb-Lundberg ◽  
...  
Keyword(s):  
North America ◽  
Hereditary Angioedema ◽  
Bradykinin Receptors ◽  
Receptor Antagonists ◽  
Endogenous Peptides ◽  
Kinin Receptors ◽  
Acute Attacks

Bradykinin (or kinin) receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Bradykinin (kinin) Receptors [76]) are activated by the endogenous peptides bradykinin (BK), [des-Arg9]bradykinin, Lys-BK (kallidin), [des-Arg10]kallidin, [Phospho-Ser6]-Bradykinin, T-kinin (Ile-Ser-BK), [Hyp3]bradykinin and Lys-[Hyp3]-bradykinin. Variation in pharmacology and activity of B1 and B2 receptor antagonists at species orthologs has been documented. icatibant (Hoe140, Firazir) is approved in North America and Europe for the treatment of acute attacks of hereditary angioedema.

Bradykinin B2 receptor antagonists: development and applications

1995 ◽  
Vol 73 (7) ◽  
pp. 787-790 ◽  
Author(s):  
John M. Stewart
Keyword(s):  
G Protein ◽  
Biomedical Research ◽  
Clinical Applications ◽  
G Protein Coupled Receptors ◽  
Bradykinin Receptors ◽  
Receptor Antagonists ◽  
Bradykinin B2 Receptor ◽  
Kinin Receptors ◽  
Bradykinin Antagonists ◽  
G Protein Coupled

Most physiological and pathophysiological responses to bradykinin are mediated by G-protein-coupled receptors designated B2 receptors. Discovery of antagonists for these receptors has brought about a revolution in research in the kinin field. The chemistry and development of antagonists for B2 kinin receptors are discussed. Uses of the antagonists in biomedical research and potential clinical applications are presented.Key words: bradykinin antagonists, bradykinin inflammation, bradykinin receptors.

scholarly journals COVID‐19 as a trigger of acute attacks in people with hereditary angioedema

2021 ◽  
Author(s):  
Aude Belbézier ◽  
Mélanie Arnaud ◽  
Isabelle Boccon‐Gibod ◽  
Fabien Pelletier ◽  
Chloé McAvoy ◽  
...  
Keyword(s):  
Hereditary Angioedema ◽  
Acute Attacks

scholarly journals An evidence-based review of the potential role of icatibant in the treatment of acute attacks in hereditary angioedema type I and II

Core Evidence ◽  
2012 ◽  
pp. 105 ◽  
Author(s):  
Bernard Floccard ◽  
Hautin ◽  
Laurence Bouillet ◽  
Coppere ◽  
Allaouchiche
Keyword(s):  
Hereditary Angioedema ◽  
Potential Role ◽  
Evidence Based ◽  
Type I ◽  
Acute Attacks

Assessment of rebound and relapse following ecallantide treatment for acute attacks of hereditary angioedema

Allergy ◽  
2012 ◽  
Vol 67 (9) ◽  
pp. 1173-1180 ◽  
Author(s):  
J. A. Bernstein ◽  
E. P. Shea ◽  
J. Koester ◽  
R. Iarrobino ◽  
W. E. Pullman
Keyword(s):  
Hereditary Angioedema ◽  
Acute Attacks
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