scholarly journals INCREASED PURINE NUCLEOSIDE PHOSPHORYLASE AND ADENOSINE DEAMINASE ACTIVITIES IN ORAL SQUAMOUS CELL CARCINOMAS IN VIVO AND IN VITRO

1990 ◽  
Vol 11 (2) ◽  
pp. 117-124 ◽  
Author(s):  
KEIZO MAEDA ◽  
KAZUHIKO MORITA ◽  
TAKAO SHIBATA ◽  
YASUHISA NAITO ◽  
HIROYUKI SUZUKI ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
Squamous Cell ◽  
Purine Nucleoside Phosphorylase ◽  
Squamous Cell Carcinomas ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
Oral Squamous Cell Carcinomas

scholarly journals Metabolism of purines in macrophages. Effect of functional state of the cells.

1980 ◽  
Vol 152 (1) ◽  
pp. 241-246 ◽  
Author(s):  
R J Soberman ◽  
M L Karnovsky
Keyword(s):  
Adenosine Deaminase ◽  
Purine Nucleoside Phosphorylase ◽  
Sodium Caseinate ◽  
Peritoneal Macrophages ◽  
Purine Nucleoside ◽  
Adenine Phosphoribosyltransferase ◽  
Nucleoside Phosphorylase ◽  
Mouse Macrophages ◽  
Different Populations

Ecto-5'-nucleotidase is known to be diminished markedly in activated compared to control mouse macrophages. The level of three purine nucleoside metabolizing enzymes, adenosine deaminase (EC 3.5.4.4), purine nucleoside phosphorylase (EC 2.4.2.1), and adenine phosphoribosyltransferase (EC 2.4.2.7) were measured in the sonicates of different populations of mouse peritoneal macrophages. Levels of adenine phosphoribosyltransferase and purine nucleoside phosphorylase in macrophages that were elicited with sodium caseinate or activated in vivo by prior intravenous injection of Listeria monocytogenes were eight times higher than those in resident cells. Levels of adenosine deaminase also tended to increase and were two times higher in elicited cells than in resident cells. The Km of each enzyme was the same in each cell population. The findings suggest that the levels of the ecto-5'-nucleotidase and of the intracellular enzymes are coordinated.

Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout

1975 ◽  
Vol 58 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Tsuneo Nishizawa ◽  
Yutaro Nishida ◽  
Ieo Akaoka ◽  
Takashi Yoshimura
Keyword(s):  
Adenosine Deaminase ◽  
Purine Nucleoside Phosphorylase ◽  
Purine Nucleoside ◽  
Phosphorylase Activity ◽  
Nucleoside Phosphorylase

scholarly journals In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells

Gene Therapy ◽  
2000 ◽  
Vol 7 (20) ◽  
pp. 1738-1743 ◽  
Author(s):  
V K Gadi ◽  
S D Alexander ◽  
J E Kudlow ◽  
P Allan ◽  
W B Parker ◽  
...  
Keyword(s):  
Purine Nucleoside Phosphorylase ◽  
Ovarian Tumors ◽  
Purine Nucleoside ◽  
Nucleoside Phosphorylase ◽  
E Coli
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