This paper analyzes the main problems in informatization of china's manufacturing industry, and researches an industrial collaborative manufacturing system for large and medium-sized manufacturing enterprises taking advantage of the benefits of cloud computing such as resource integration, elastic computing, mass data, and service integration. The system includes technical support system, business support system, security system and service portal, which providing design collaboration services, production collaboration services, business collaboration services, office collaboration services for enterprises, and forming a complete standard system. This will further promote the innovation of the service model and change of economic growth mode in our country.