scholarly journals Cavernous sinus meningiomas

2018 ◽  
Vol 20 (2) ◽  
pp. 110-118
Author(s):  
Roberto Spiegelmann ◽  
Zvi R. Cohen ◽  
Uzi Nissim
Keyword(s):  
Stereotactic Radiosurgery ◽  
Cavernous Sinus ◽  
Linear Accelerator ◽  
Medical Center ◽  
Neurological Complications ◽  
Formidable Challenge ◽  
Long Term Follow Up ◽  
Low Incidence

Introduction: Tumors of the cranial base arising from or partially involving the cavernous sinus have represented a formidable challenge to neurosurgeons. Stereotactic radiosurgery represents an alternative to microsurgery for the management of cavernous sinus meningiomas. The present study aims to evaluate the results of radiosurgery in a large series of patients treated with a linear accelerator with a long-term follow-up. Patients and Methods: From 1993 through 2007, 462 patients with meningiomas underwent radiosurgery at the Chaim Sheba Medical Center LINAC radiosurgery unit. Of those, 117 had tumors involving predominantly the cavernous sinus. A mean follow-up of 67 months was obtained in 102 patients (range:12 to 180 months). Patients’ age ranged from 31 to 86 years (mean 57). Seventy two (70%) were females. Thirty five patients (34.3%) were initially submitted to microsurgery and 67 (65.6%) underwent stereotactic radiosurgery as the first treatment option. Patients were treated using a linear accelerator with cylindrical collimators in 44 patients (43.1%) and a minimultileaf collimator in 58 patients (56.8%). The prescription dose was delivered to the 60 to 80% isodose line (mean, 68%) in patients treated with cylindrical collimators, and to the 80% in those treated with a single conformal isocenter. Doses ranged between 12 and 17.5 Gy (mean, 13.5 Gy). Median tumor volume was 7.2 cm3 (range 0.61–23 cm3). Results: All patients were available for follow-up at 12 to 180 months after treatment (mean, 68 months; median, 60 months). The actuarial control rate was 98%. Fifty nine  patients (58%) had a volume reduction and forty one (40%) had stable tumor volumes at the end of follow-up. Two tumors grew. Overall, 4 patients had a new lasting neurological deficit (facial hypesthesia or pain in two, trochlear neuropathy in two, and visual defect in one), for an incidence of 4% in persistent neurological complications. Conclusions: This series of linear accelerator radiosurgery confirms that in the short and long term, radiosurgery affords excellent control for cavernous sinus meningiomas with a very low incidence of complications. Radiosurgery can thus be regarded as the treatment of choice for cavernous sinus meningiomas. 

scholarly journals P12.07 Long term follow-up of cavernous sinus meningiomas after stereotactic radiosurgery

2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii96-iii96
Author(s):  
R. Daniel ◽  
F. Fritsche ◽  
S. Grau ◽  
H. Treuer ◽  
M. Kocher ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Cavernous Sinus ◽  
Long Term Follow Up

Low incidence of late failure and toxicity after spine stereotactic radiosurgery: Secondary analysis of phase I/II trials with long-term follow-up

2019 ◽  
Vol 138 ◽  
pp. 80-85 ◽  
Author(s):  
Matthew S. Ning ◽  
Brian J. Deegan ◽  
Jennifer C. Ho ◽  
Bhavana V. Chapman ◽  
Andrew J. Bishop ◽  
...  
Keyword(s):  
Phase I ◽  
Stereotactic Radiosurgery ◽  
Secondary Analysis ◽  
Late Failure ◽  
Long Term Follow Up ◽  
Low Incidence

Low Incidence of Adrenal Insufficiency after Transsphenoidal Surgery in Patients with Acromegaly: A Long-Term Follow-Up Study

2011 ◽  
pp. P3-284-P3-284
Author(s):  
AnneMarij G Burgers ◽  
Nieke E Kokshoorn ◽  
Alberto M Pereira ◽  
Ferdinand Roelfsema ◽  
Johannes WA Smit ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Transsphenoidal Surgery ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Low Incidence

scholarly journals Reliability of Wastewater Analysis for Monitoring COVID-19 Incidence Revealed by a Long-Term Follow-Up Study

2021 ◽  
Vol 1 ◽  
Author(s):  
Rafael Sanjuán ◽  
Pilar Domingo-Calap
Keyword(s):  
Viral Genome ◽  
Population Level ◽  
Wastewater Analysis ◽  
Disease Notification ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Low Incidence ◽  
Rna Concentration

Wastewater-based epidemiology has been used for monitoring human activities and waterborne pathogens. Although wastewaters can also be used for tracking SARS-CoV-2 at the population level, the reliability of this approach remains to be established, especially for early warning of outbreaks. We collected 377 samples from different treatment plants processing wastewaters of >1 million inhabitants in Valencia, Spain, between April 2020 and March 2021. Samples were cleaned, concentrated, and subjected to RT-qPCR to determine SARS-CoV-2 concentrations. These data were compared with cumulative disease notification rates over 7 and 14 day periods. We amplified SARS-CoV-2 RNA in 75% of the RT-qPCRs, with an estimated detection limit of 100 viral genome copies per liter (gc/L). SARS-CoV-2 RNA concentration correlated strongly with disease notification rates over 14-day periods (Pearson r = 0.962, P < 0.001). A concentration >1000 gc/L showed >95% sensitivity and specificity as an indicator of more than 25 new cases per 100,000 inhabitants. Albeit with slightly higher uncertainty, these figures were reproduced using a 7-day period. Time series were similar for wastewaters data and declared cases, but wastewater RNA concentrations exhibited transient peaks that were not observed in declared cases and preceded major outbreaks by several weeks. In conclusion, wastewater analysis provides a reliable tool for monitoring COVID-19, particularly at low incidence values, and is not biased by asymptomatic cases. Moreover, this approach might reveal previously unrecognized features of COVID-19 transmission.

Outcomes of 33 patients from the wars in Iraq and Afghanistan undergoing bilateral or bicompartmental craniectomy

2011 ◽  
Vol 115 (1) ◽  
pp. 124-129 ◽  
Author(s):  
Robert D. Ecker ◽  
Lisa P. Mulligan ◽  
Michael Dirks ◽  
Randy S. Bell ◽  
Meryl A. Severson ◽  
...  
Keyword(s):  
Medical Center ◽  
Systemic Infection ◽  
Categorical Variables ◽  
Cerebrovascular Injury ◽  
The Us ◽  
Long Term Follow Up ◽  
Initial Injury ◽  
Gcs Score

Object There are no published long-term data for patients with penetrating head injury treated with bilateral supratentorial craniectomy, or supra- and infratentorial craniectomy. The authors report their experience with 33 patients treated with bilateral or bicompartmental craniectomy from the ongoing conflicts in Iraq and Afghanistan. Methods An exploratory analysis of Glasgow Outcome Scale (GOS) scores at 6 months in 33 patients was performed. Follow-up lasting a median of more than 2 years was performed in 30 (91%) of these patients. The association of GOS score with categorical variables was explored using the Wilcoxon rank-sum test or Kruskal-Wallis analysis of variance. The Spearman correlation coefficient was used for ordinal/continuous data. To provide a clinically meaningful format to present GOS scores with categorical variables, patients with GOS scores of 1–3 were categorized as having a poor outcome and those with scores of 4 and 5 as having a good outcome. This analysis does not include the patients who died in theater or in Germany who underwent bilateral decompressive craniectomy because those figures have not been released due to security concerns. Results All patients were men with a median age of 24 years (range 19–46 years) and a median initial Glasgow Coma Scale (GCS) score of 5 (range 3–14). At 6 months, 9 characteristics were statistically significant: focus of the initial injury, systemic infection, initial GCS score, initial GCS score excluding patients with a GCS score of 3, GCS score on arrival to the US, GCS score on dismissal from the medical center, Injury Severity Score, and patients with cerebrovascular injury. Six factors were significant at long-term follow-up: focus of initial injury, systemic infection, initial GCS score excluding patients with a GCS score of 3, GCS score on arrival to the US, and GCS score on dismissal from the medical center. At long-term follow-up, 7 (23%) of 30 patients had died, 5 (17%) of 30 had a GOS score of 2 or 3, and 18 (60%) of 30 had a GOS score of 4 or 5. Conclusions In this selected group of patients who underwent bilateral or bicompartmental craniectomy, 60% are independent at long-term follow-up. Patients with bifrontal injury fared best. Systemic infection and cerebrovascular injury corresponded with a worse outcome.

Salvage Surgical Resection After Linac-based Stereotactic Radiosurgery and Radiotherapy for Newly Diagnosed Brain Metastasis

2021 ◽  
Author(s):  
Ryosuke Matsuda ◽  
Takayuki Morimoto ◽  
Tetsuro Tamamoto ◽  
Nobuyoshi Inooka ◽  
Tomoko Ochi ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Survival Time ◽  
Stereotactic Radiosurgery ◽  
Surgical Resection ◽  
Cyst Formation ◽  
Histopathological Diagnosis ◽  
Newly Diagnosed ◽  
Long Term Follow Up

Abstract Purpose: This study aimed to assess the clinical outcomes of salvage surgical resection (SSR) after stereotactic radiosurgery and fractionated stereotactic radiotherapy (SRS/fSRT) for brain metastasis.Methods: Between November 2009 and December 2018, we treated 427 consecutive patients with 919 lesions with SRS/fSRT for newly diagnosed brain metastasis at our hospital. During the follow-up period, we treated 19 consecutive patients who underwent 21 SSRs for recurrence, radiation necrosis (RN), and cyst formation after SRS/fSRT for newly diagnosed brain metastasis. Two patients underwent multiple surgical resections. Brain metastasis originated from the lung (n=15, 78.9%), breast (n=3, 15.7%), and colon (n=1, 5.2%). Results: The median time from initial SRS/fSRT to SSR was 14 months (range: 2–96 months). The median follow-up after SSR was 15 months (range: 2–76 months). The range of tumor volume at initial SRS/SRT was 0.121–21.459 cm3 (median: 2.188 cm3). Histopathological diagnosis after SSR was recurrence, RN and cyst formation in 13 and 6 cases, respectively. The median survival time from SSR and from initial SRS/SRT was 17 months and 74 months, respectively. The cases with recurrence had a significantly shorter survival time than those without recurrence (p=0.0453).Conclusion: The patients treated with SRS/fSRT for brain metastasis need long-term follow-up. SSR is a safe and effective treatment for the recurrence, RN, and cyst formation after SRS/fSRT for brain metastasis.

scholarly journals Low Incidence of Gastrointestinal Bleeding and Pump Thrombosis in Patients Receiving the INCOR LVAD System in the Long-term Follow-up

2015 ◽  
Vol 38 (10) ◽  
pp. 542-547 ◽  
Author(s):  
Attilio Iacovoni ◽  
Paolo Centofanti ◽  
Matteo Attisani ◽  
Alessandro Verde ◽  
Amedeo Terzi ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Pump Thrombosis ◽  
Long Term Follow Up ◽  
Low Incidence

Long-Term Follow-Up of 32 Meningiomas of the Clivus and Foramen Magnum Subjected to Stereotactic Radiosurgery

Radiosurgery ◽  
2010 ◽  
pp. 202-211
Author(s):  
K. Sallabanda ◽  
J.C. Bustos ◽  
J.A. Gutiérrez-Díaz ◽  
C. Beltrán ◽  
C. Peraza ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Foramen Magnum ◽  
Long Term Follow Up
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