scholarly journals HUBUNGAN ANTARA STATUS RESEPTOR ESTROGEN, RESEPTOR PROGESTERON DAN HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 DENGAN DERAJAT KEGANASAN KARSINOMA PAYUDARA INVASIF

2016 ◽  
Vol 39 (2) ◽  
pp. 65
Author(s):  
Muhartono Muhartono ◽  
Soraya Ramanisa ◽  
Hanna Mutiara ◽  
Ria Janita Riduan
Keyword(s):  
Estrogen Receptor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Progesterone Receptor ◽  
Growth Factor Receptor ◽  
Low Grade ◽  
Human Epidermal Growth Factor ◽  
Her 2 ◽  
Epidermal Growth

Karsinoma payudara invasif (KPI) merupakan keganasan yang berasal dari epitel saluran kelenjar susu dan menginvasi jaringan sekitarnya. Pemeriksaan patologi anatomi biasanya menyertakan derajat keganasan (DKg) dan dilanjutkan dengan pemeriksaan imunohistokimia estrogen receptor (ER), progesterone receptor (PR) dan human epidermal growth factor receptor 2 (HER2) untuk menentukan terapi dan memperkirakan prognosis. Penelitian ini bertujuan untuk mengetahui hubungan status ER, PR, HER–2 dengan DKg pada KPI. Subjek penelitian yang digunakan adalah pasien KPI yang telah diperiksa DKg, status ER, PR dan HER–2 pada tahun 2014–2015 di RSUD Abdoel Moeloek Bandar Lampung. Hasil penelitian menunjukkan DKg low grade sebanyak 13 pasien (24,1%), high grade sebanyak 41 pasien (75,9%), status ER‒ sebanyak 32 pasien (50,3%), ER+ sebanyak 22 pasien (40,7%), PR‒ sebanyak 32 pasien (59,3%), PR+ sebanyak 22 (40,7%) dan HER2‒ sebanyak 33 pasien (61,1%), HER2+ sebanyak 21 pasien (38,9%). Hasil uji Chi‒Square antara ER dengan DKg nilai p=0,001, antara PR dengan DKg nilai p=0,002, antara HER2 dengan DKg nilai p=0,53. Simpulan, terdapat hubungan antara estrogen receptor dan progesterone receptor dengan derajat keganasan pada karsinoma duktal invasif.

scholarly journals Distribution and Prognostic Significance of Estrogen Receptor α (ERα), Estrogen Receptor β (ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Anjali Mishra ◽  
Niraj Kumari ◽  
Chandan Kumar Jha ◽  
Raouef Ahamed Bichoo ◽  
Shravan Kumar Mishra ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Epidermal Growth Factor Receptor ◽  
Prognostic Factors ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Thyroid Carcinoma ◽  
Growth Factor Receptor ◽  
Human Epidermal Growth Factor ◽  
Her 2 ◽  
Epidermal Growth

Purpose. The primary aim of this study was to determine the incidence of estrogen receptor α (ERα), estrogen receptor β (ERβ), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic prognostic factors. Methods. Immunohistochemistry analysis was performed on archival paraffin-embedded tissue sections (1991–2016). ERα, ERβ, and HER-2 expressions were correlated with clinicopathologic prognostic factors, disease recurrence, and overall survival (OS). Results. A total of 264 TC patients were included in the study. Incidences of ERα, ERβ, and HER-2 were 8.1 vs 16.3 vs 13.9% p=0.15, 26.6 vs 11.5 vs 36.1% p=0.002, and 12.9 vs 2.9 vs 0% p=0.003 in papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), and poorly differentiated thyroid carcinoma (PDTC), respectively. Overall ERα had significant correlation with distant metastases (0.038) and in case of PDTC with multicentricity p=0.037. ERβ had significant correlation with lymph node metastases p=0.023 in FTC. HER-2 correlated with tumor size p=0.027 only on univariate analysis. OS did not correlate with expression of any receptor. Conclusion. ERα, ERβ, and HER-2 have differential expression and prognostic implications in different TC subtypes.

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