Polydipsia-polyuria syndrome associated with traumatic spinal cord injury

Polydipsia and polyuria associated with traumatic spinal cord injury (SCI) are rare consequences. The hypothetical pathophysiological mechanisms involve mild traumatic brain injury (TBI) and/or vagus dysfunction associated with spinal cord injury. In a retrospective study of 11 patients, we investigated associations between polydipsia-polyuria syndrome and various clinical and therapeutic factors: medullary section syndrome, neurological level, medication, neurosurgical intervention, kinesitherapy program, associated comorbidities, functional level at discharge and patient quality of life (QoL). The beginning of the kinetic program (Spearman correlation coefficient = 0.631) and desmopressin treatment (Spearman correlation coefficient = 0.708) had statistically significant effects on resolution ofPPS. Patient QoL was statistically significant improved after resolution ofPPS (t-test, p = 0.001).