The Predictive Value of Pre-Implant Pulmonary Function Testing in LVAD Patients

Abstract BackgroundCardiopulmonary exercise testing (CPET) and pulmonary function testing (PFT) are noninvasive methods to evaluate the respiratory and circulatory systems. This research aimed to evaluate and monitor chronic thromboembolic pulmonary hypertension (CTEPH) noninvasively and effectively. At the same time assess the predictive value of CPET and PFT parameters for the aggravation of CTEPH. MethodsWe used data from 86 CTEPH patients (55 for test set, and 31 for validation set) at the Shanghai Pulmonary Hospital Affiliated to Tongji University. The clinical, PFT and CPET parameters of mild, moderate and severe CPET patients classified according to PAP (mm Hg) were compared. Logistic regression analysis was performed to appraise the predictive value of each potential predictor for severe CTEPH. The performance of PFT and CPET parameters for predicting severe CTEPH was determined by receiver operating characteristic (ROC) curves and calibration curves.ResultsData showed that Load @ Peak (W), FEV1/FVC (%), and VE @ AT (L/min) were independent risk factors for severe CTEPH classified according to PAP (mm Hg). Additionally, the efficacy of the use of Load @ Peak (W), FEV1/FVC (%) and VE @ AT (L/min) in identifying severe CTEPH was found to be moderate with area under the curve (AUC) of ROC curves of 0.736, 0.696 and 0.769, respectively. Furthermore, combination with Load @ Peak (W), FEV1/FVC (%) and VE @ AT (L/min) had a moderate utility value in identifying severe CTEPH with an AUC of 0.897.ConclusionOur data suggests that PFT and CPET parameters can noninvasively and effectively evaluate, monitor and predict the aggravation of CTEPH.

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Cardiopulmonary exercise testing and pulmonary function testing for predicting the severity of CTEPH

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01668-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hanqing Zhu ◽

Xingxing Sun ◽

Yuan Cao ◽

Bigyan Pudasaini ◽

Wenlan Yang ◽

...

Keyword(s):

Pulmonary Function ◽

Exercise Testing ◽

Predictive Value ◽

Minute Ventilation ◽

Cardiopulmonary Exercise Testing ◽

Chronic Thromboembolic Pulmonary Hypertension ◽

Pulmonary Function Testing ◽

Noninvasive Methods ◽

Cardiopulmonary Exercise ◽

Function Testing

Abstract Background Cardiopulmonary exercise testing (CPET) and pulmonary function testing (PFT) are noninvasive methods to evaluate the respiratory and circulatory systems. This research aims to evaluate and monitor chronic thromboembolic pulmonary hypertension (CTEPH) noninvasively and effectively by these two methods. Moreover, the research assesses the predictive value of CPET and PFT parameters for severe CTEPH. Methods We used data from 86 patients with CTEPH (55 for test set, and 31 for validation set) at the Shanghai Pulmonary Hospital Affiliated to Tongji University. The clinical, PFT and CPET data of CTEPH patients of different severity classified according to pulmonary artery pressure (PAP) (mm Hg) were collected and compared. Logistic regression analysis was performed to appraise the predictive value of each PFT and CPET parameter for severe CTEPH. The performance of CPET parameters for predicting severe CTEPH was determined by receiver operating characteristic (ROC) curves and calibration curves. Results Data showed that minute ventilation at anaerobic threshold (VE @ AT) (L/min) and oxygen uptake at peak (VO2 @ peak) (mL/kg/min) were independent predictors for severe CTEPH classified according to PAP (mm Hg). Additionally, the efficacy of VE @ AT (L/min) and VO2 @ peak (mL/kg/min) in identifying severe CTEPH was found to be moderate with the area under ROC curve (AUC) of 0.769 and 0.740, respectively. Furthermore, the combination of VE @ AT (L/min) and VO2 @ peak (mL/kg/min) had a moderate utility value in identifying severe CTEPH with the AUC of 0.843. Conclusion Our research suggests that CPET and PFT can noninvasively and effectively evaluate, monitor and predict the severity of CTEPH.

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Predictive value of pulmonary function testing during pulmonary exacerbations in cystic fibrosis

Pediatric Pulmonology ◽

10.1002/ppul.1950160404 ◽

1993 ◽

Vol 16 (4) ◽

pp. 227-235 ◽

Cited By ~ 15

Author(s):

Samuel M. Rosenberg ◽

Craig M. Schramm

Keyword(s):

Cystic Fibrosis ◽

Pulmonary Function ◽

Predictive Value ◽

Pulmonary Function Testing ◽

Pulmonary Exacerbations ◽

Function Testing

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Specifications for equipment used for infant pulmonary function testing

European Respiratory Journal ◽

10.1034/j.1399-3003.2000.16d28.x ◽

2000 ◽

Vol 16 (4) ◽

pp. 731 ◽

Cited By ~ 131

Author(s):

U. Frey ◽

J. Stocks ◽

A Coates ◽

P Sly ◽

J Bates ◽

...

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Testing ◽

Function Testing ◽

Infant Pulmonary Function ◽

Infant Pulmonary Function Testing

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Faculty Opinions recommendation of High resolution computerized tomography of the chest and pulmonary function testing in evaluating the effect of tobramycin solution for inhalation in cystic fibrosis patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1048405.500315 ◽

2006 ◽

Author(s):

David Lynch

Keyword(s):

Cystic Fibrosis ◽

High Resolution ◽

Pulmonary Function ◽

Computerized Tomography ◽

Pulmonary Function Testing ◽

Function Testing

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Pulmonary Function Testing in Work-Related Asthma: An Overview from Spirometry to Specific Inhalation Challenge

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18052325 ◽

2021 ◽

Vol 18 (5) ◽

pp. 2325

Author(s):

Mathias Poussel ◽

Isabelle Thaon ◽

Emmanuelle Penven ◽

Angelica I. Tiotiu

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Tests ◽

Objective Evaluation ◽

Pulmonary Function Testing ◽

Initial Assessment ◽

Work Related ◽

Specific Inhalation Challenge ◽

Occupational Setting ◽

Inhalation Challenge ◽

Function Testing

Work-related asthma (WRA) is a very frequent condition in the occupational setting, and refers either to asthma induced (occupational asthma, OA) or worsened (work-exacerbated asthma, WEA) by exposure to allergens (or other sensitizing agents) or to irritant agents at work. Diagnosis of WRA is frequently missed and should take into account clinical features and objective evaluation of lung function. The aim of this overview on pulmonary function testing in the field of WRA is to summarize the different available tests that should be considered in order to accurately diagnose WRA. When WRA is suspected, initial assessment should be carried out with spirometry and bronchodilator responsiveness testing coupled with first-step bronchial provocation testing to assess non-specific bronchial hyper-responsiveness (NSBHR). Further investigations should then refer to specialists with specific functional respiratory tests aiming to consolidate WRA diagnosis and helping to differentiate OA from WEA. Serial peak expiratory flow (PEF) with calculation of the occupation asthma system (OASYS) score as well as serial NSBHR challenge during the working period compared to the off work period are highly informative in the management of WRA. Finally, specific inhalation challenge (SIC) is considered as the reference standard and represents the best way to confirm the specific cause of WRA. Overall, clinicians should be aware that all pulmonary function tests should be standardized in accordance with current guidelines.

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