scholarly journals Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus

2020 ◽  
Author(s):  
Yanis Ramdani ◽  
Cécile Bergua ◽  
Christelle Barbet ◽  
François Maillot ◽  
Adrien Bigot ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Myeloid Cells ◽  
Fc Receptor ◽  
Receptor Expression ◽  
Systemic Lupus ◽  
Neonatal Fc Receptor

scholarly journals Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus

Lupus ◽  
2021 ◽  
pp. 096120332110450
Author(s):  
Ramdani Yanis ◽  
Cécile Bergua ◽  
Barbet Christelle ◽  
François Maillot ◽  
Adrien Bigot ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Fc Receptor ◽  
Receptor Expression ◽  
Inactive Disease ◽  
Systemic Lupus ◽  
Neonatal Fc Receptor ◽  
Blood Leukocytes ◽  
Healthy Donors ◽  
Monocyte Subpopulations

The neonatal Fc receptor (FcRn) is a ubiquitously expressed protein historically involved in IgG and albumin recycling. Recent data suggest an involvement in the pathophysiology of antibody-mediated autoimmune diseases. Among them, systemic lupus erythematosus (SLE) implies clinical and biological abnormalities of innate and adaptive circulating immune cells, potentially involving newly described functions of FcRn. In this study, FcRn expression was assessed by flow cytometry in peripheral blood leukocytes of 41 SLE patients with either active or inactive disease and 32 healthy donors. FcRn expression in B cells, natural killer cells, and T cells of SLE patients was statistically lower as compared to healthy donors. Conversely, FcRn level was statistically higher in non-classical monocyte subpopulations (CD14+CD16+ monocytes) of SLE patients versus healthy donors providing an interesting perspective to further explore its role in SLE pathophysiology.

Association between Fc receptor-like 3 C169T polymorphism and risk of systemic lupus erythematosus: a meta-analysis

2009 ◽  
Vol 37 (1) ◽  
pp. 191-196 ◽  
Author(s):  
Chen Mao ◽  
Haifeng Pan ◽  
Qing Chen ◽  
Xiwen Wang ◽  
Dongqing Ye ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Fc Receptor ◽  
Systemic Lupus

scholarly journals A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus

1982 ◽  
Vol 25 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Max I. Hamburger ◽  
Thomas J. Lawley ◽  
Robert P. Kimberly ◽  
Paul H. Plotz ◽  
Michael M. Frank
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Functional Activity ◽  
Reticuloendothelial System ◽  
Fc Receptor ◽  
Systemic Lupus
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