scholarly journals Primary Thromboprophylaxis to Prevent Thrombotic Events in Pediatric Oncology Patients with a Malignant Mediastinal Mass.

Author(s):  
Susmita Sarangi ◽  
Marian Gaballah ◽  
Deirdre Nolfi-Donegan ◽  
Maria Battaglia ◽  
Seema Amin ◽  
...  

Children with malignant mediastinal masses have increased thrombotic events (TE). We examined primary thromboprophylaxis in reducing TE. Eligible subjects were started on enoxaparin thromboprophylaxis and compared to a cohort without. There were 15 TEs among 76 subjects for an incidence of 19.7%. Mediastinal compression directly led to TE, (M-TE) in 9.2% of subjects requiring 2-fold longer duration of therapeutic anticoagulation. Primary thromboprophylaxis revealed a trend towards reduction in M-TE although not statistically significant. The M-TE subjects had greater superior vena caval compression at diagnosis (p=0.033). We conclude that strategic thromboprophylaxis guided by monitoring dynamic vascular compression can improve TE outcomes.

2016 ◽  
Vol 22 (1) ◽  
pp. 23
Author(s):  
A C Jeevarathnum ◽  
A Van Niekerk ◽  
D Parris ◽  
K De Campos ◽  
W Wijnant ◽  
...  

<div><p>The exact incidence of superior mediastinal masses in children is largely unknown. They present as a spectrum of disease ranging from an incidental finding on a Chest X-Ray to being markedly symptomatic with superior vena caval syndrome or obstruction of the upper airways.  Lymphomas seem to be the most common causes of superior mediastinal masses in children.  We present two cases of confirmed T cell lymphoma in children with superior mediastinal masses.  In doing so, we explore a diagnostic approach and visit the complications the physician needs to be aware of when confronted with a child with a superior mediastinal mass.</p></div>


2021 ◽  
Author(s):  
Susmita N. Sarangi ◽  
Marian Gaballah ◽  
Deirdre Nolfi‐Donegan ◽  
Maria Battaglia ◽  
Seema Amin ◽  
...  

2006 ◽  
Author(s):  
Kristina K. Hardy ◽  
Melanie J. Bonner ◽  
Katherine C. Hutchinson ◽  
Victoria W. Willard

2007 ◽  
Author(s):  
Stephen R. Lassen ◽  
Brent Collett ◽  
Stan Whitsett ◽  
Debra Friedman

1993 ◽  
Vol 161 (5) ◽  
pp. 1110-1111 ◽  
Author(s):  
M A Picou ◽  
R Antonovic ◽  
W E Holden

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