COVID-19 in a Pregnant Patient with Beta-Thalassemia Major: A Case Report

We report a case of a 35-years-old Lebanese pregnant lady with a background of beta-thalassemia major who was diagnosed with COVID-19 infection (Cycle threshold value 18) during her 23rd gestational week. Unfortunately, the pregnancy outcome was unfavorable. To our knowledge, this is the first report of such a case

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COVID‐19 in a pregnant patient with beta‐thalassemia major: A case report

Clinical Case Reports ◽

10.1002/ccr3.4331 ◽

2021 ◽

Vol 9 (7) ◽

Author(s):

Yousef Mohammed Ali Hailan ◽

Gamal Sayed ◽

Mohamed A. Yassin

Keyword(s):

Case Report ◽

Pregnant Patient ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Beta Thalassemia Major

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A first case of hemoglobin Castilla [Beta 32(B14) Leu>Arg; HBB: c.98T>G] associated with [IVS-I-1 (G>A); HBB:c.92+1G>A] mutation found in a Syrian betathalassemia patient

Thalassemia Reports ◽

10.4081/thal.2020.8396 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Ahmad Shoujaa ◽

Yasser Mukhalalaty ◽

Hossam Murad ◽

Faizeh Al-Quobaili

Keyword(s):

Molecular Analysis ◽

Clinical Case ◽

Globin Gene ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Blood Transfusions ◽

Beta Globin ◽

First Report ◽

Beta Thalassemia Major ◽

First Case

Beta thalassemia (β-thal) is one of the most common worldwide inherited hemoglobinopathies. Proper identification and diagnosis of hemoglobin (Hb) variants provide a major challenge. In this report, we describe a 1-year-old boy, presented with the diagnosis of β-TM (beta thalassemia major), has received regular blood transfusions. The molecular analysis revealed the presence of rare Hb Castilla [Beta 32(B14) Leu>Arg; HBB: c.98T>G] variant associated with β0 [IVS-I-1 (G>A); AG^GTTGGT- >AGATTGGT beta0] (HBB:c.92+1G>A) Mutation in beta-globin (β-globin) gene. To our knowledge, this is the first report of Hb Castilla [Beta 32(B14) Leu>Arg] in ExonII of β-globin gene which were found in Syrian male proband. However, we should investigate abnormal hemoglobins in patients with beta thalassemia to determine whether they have involvement with β-thalassemia mutations in the clinical case of the patients or not.

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AB131. Case report: a couple having a child affected with beta thalassemia major and another child with hydrops fetalis

Annals of Translational Medicine ◽

10.21037/atm.2017.s131 ◽

2017 ◽

Vol 5 (S2) ◽

pp. AB131-AB131

Author(s):

Thi Tuyet Nhung Ngo ◽

Thi Thanh Ha Ly ◽

Diem Ngoc Ngo ◽

Thi Phuong Mai Nguyen ◽

Thuy Lan An ◽

...

Keyword(s):

Case Report ◽

Thalassemia Major ◽

Hydrops Fetalis ◽

Beta Thalassemia ◽

Beta Thalassemia Major

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Comprehensive management of refractory autoimmune hemolytic anemia in pediatric beta-thalassemia major patient: A case report

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2021.102853 ◽

2021 ◽

pp. 102853

Author(s):

Vincencius William ◽

Desy Rusmawatiningtyas ◽

Firdian Makrufardi ◽

Pudjo Hagung Widjajanto

Keyword(s):

Case Report ◽

Hemolytic Anemia ◽

Autoimmune Hemolytic Anemia ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Comprehensive Management ◽

Beta Thalassemia Major ◽

Thalassemia Major Patient

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A Case Report: Infertility Treatment of a Female with Beta-thalassemia Major

Journal of the Bahrain Medical Society ◽

10.26715/jbms.33_2021_2_6 ◽

2021 ◽

Vol 33 (2) ◽

Keyword(s):

Case Report ◽

Medical Condition ◽

Endometrial Thickness ◽

Intrauterine Insemination ◽

Embryo Implantation ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Blood Transfusions ◽

Beta Globin ◽

Beta Thalassemia Major

Beta-thalassemia is caused by a genetically mediated deletion of beta-globin chain of hemoglobin. It is an autosomal recessive disease, which causes a severe medical condition that requires longterm blood transfusions. An impaired hypothalamic-pituitary-ovarian axis mainly causes infertility in such patients. This case report presents a 26-year-old female, a known case of beta-thalassemia major, that received monthly blood transfusions before conceiving. The patient sought consultation for the treatment of primary infertility at Bahrain Defence Force Royal Medical Services (BDF-RMS) Hospital. The patient underwent two trials of intrauterine insemination (IUI). The goal was to build up endometrial thickness by gonadotrophins administration for embryo implantation. To conclude, IUI combined with gonadotrophins for ovarian stimulation has shown success. Keywords: Artificial Insemination, Beta-Thalassemia, Hypogonadism, Infertility, Pregnancy

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COMPLICATIONS OF IRON OVERLOAD IN BETA THALASSEMIA- AN AUTOPSY CASE REPORT

10.36106/gjra/7600696 ◽

2021 ◽

pp. 14-16

Author(s):

Meenakshi Balasubramanian ◽

Niyati Sangoi

Keyword(s):

Case Report ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Autopsy Case ◽

Asian Countries ◽

Beta Thalassemia Major ◽

Common Causes ◽

High Incidence ◽

Hereditary Disorders ◽

Common Group

Beta thalassemias are a common group of hereditary disorders that have a high incidence in south Asian countries like India. The following article presents an autopsy case report of a patient with beta thalassemia major discussing the various clinicopathological features, gross and histopathological ndings. Common causes of death in patients with beta thalassemia major, various screening modalities for early detection of carriers, diagnosis and treatment have also been discussed, along with the review of literature.

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