Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis

Granular cell tumors (GCT) are rare benign tumors. Less than 1% of GCTs involve the extrahepatic biliary tree. Most researches favor a Schwann cell origin. Patient, caucasion, female, 31 year old presented with 4 month history of painless jaundice and pruritus. US and CT revealed dilatation of intrahepatic biliary tree and surgery was performed. Firm tumor mass was found above the conjunction of cystic duct and common hepatic duct (CHD) that caused obstruction and gallblader empyema. The patient underwent radical surgical procedure because Klatskin tumor was clinically suspected. Patohystology and immunohistochemistry confirmed granular cell tumor. Eight years after surgery the patient is wellbeing without symptoms. To our knowledge 69 cases of GCT of the extrahepatic biliary tree have been reported and none of the acute acalculous cholecystitis case accompanied by GCT of CHD. Granular cell tumors are rarely diagnosed preoperatively. Wide resection offers the best chance for cure.

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Biliary Duct Granular Cell Tumor: A Rare But Surgically Curable Benign Tumor

HPB Surgery ◽

10.1155/1993/68037 ◽

1993 ◽

Vol 6 (4) ◽

pp. 311-317 ◽

Cited By ~ 8

Author(s):

W. David Lewis ◽

Joseph F. Buell ◽

Roger L. Jenkins ◽

Peter A. Burke

Keyword(s):

Granulosa Cell ◽

Granular Cell Tumor ◽

Granulosa Cell Tumor ◽

Granular Cell ◽

Surgical Excision ◽

Biliary Tree ◽

Cell Tumor ◽

The Body ◽

Benign Tumors ◽

Biliary Duct

Granulosa cell tumors are rare benign tumors which may be found throughout the body. Rare cases are isolated within the biliary tree. If completely resected, surgical excision is curative.A case of biliary duct granulosa cell tumor is presented with review of the world’s literature on this topic.

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Granular Cell Tumor of the Common Hepatic Duct as an Unusual Cause of Jaundice in a Hepatitis C Patient

ACG Case Reports Journal ◽

10.14309/crj.2016.18 ◽

2016 ◽

Vol 3 (2) ◽

pp. 115-117 ◽

Cited By ~ 2

Author(s):

Tripti R. Chopade ◽

Colin L. Smith ◽

Warren R. Maley ◽

Ali A. Siddiqui ◽

David A. Sass

Keyword(s):

Hepatitis C ◽

Granular Cell Tumor ◽

Hepatic Duct ◽

Granular Cell ◽

Cell Tumor ◽

Common Hepatic Duct ◽

The Common

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Granular Cell Tumor of the Biliary Tree: A Rare Cause of Limy Bile

Digestive Surgery ◽

10.1159/000171956 ◽

1990 ◽

Vol 7 (2) ◽

pp. 122-124 ◽

Cited By ~ 1

Author(s):

Milton A. Gumbs ◽

Guillermo P. Narvaez, Jr. ◽

Adel Faltaous ◽

Ye Hum Kim ◽

Paul H. Gerst

Keyword(s):

Granular Cell Tumor ◽

Granular Cell ◽

Biliary Tree ◽

Cell Tumor ◽

Limy Bile

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A Rare Case of a Metastatic Malignant Abrikossoff Tumor

Case Reports in Oncology ◽

10.1159/000520385 ◽

2021 ◽

pp. 1868-1875

Author(s):

Mohamed Tayeb Salaouatchi ◽

Sandra De Breucker ◽

Héloise Rouvière ◽

Véronique Lesage ◽

Laureen Jeanne Armande Rocq ◽

...

Keyword(s):

Granular Cell Tumor ◽

Soft Tissues ◽

Granular Cell ◽

Cell Tumor ◽

Benign Tumors ◽

Large Size ◽

Positron Emission ◽

History Of ◽

Malignant Granular Cell Tumor ◽

Malignant And Benign Tumors

Abrikossoff tumor, also called granular cell tumor (GCT), is a neoplasm of the soft tissues which is most commonly a solitary, painless, and benign tumor. However, 2% of Abrikossoff tumors can be malignant. We report here the case of a 75-year-old male who presented a local recurrence of Abrikossoff tumor of the left thigh. The anatomopathological analysis concluded to a malignant GCT, and the F-18 fluorodeoxyglucose positron emission tomography showed multiple lesions in the lymph nodes and bones. The potential conversion to malignancy should alert practitioners because of the extremely poor prognosis. The diagnosis of malignant granular cell tumor should be based on a bundle of clinical and histological features and not solely on histologic features because of the challenging distinction between malignant and benign tumors due to the lack of well-defined criteria for the diagnosis of malignancy. Large size and recurrence are the most important clinical features predicting malignant behavior. Patients with a history of Abrikossoff tumor should be followed closely to monitor recurrence and malignant transformation. The apparent originality of our observation – which could lie in the evolution of a GCT tumor, initially considered as benign, to a malignant form – has to be challenged regarding the issue of classifying some cases according to the classical “benign” and “malignant” dichotomy.

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Anomalous anatomical variation in extrahepatic biliary tree and pancreas and its related vessels: a cadaveric study

International Surgery Journal ◽

10.18203/2349-2902.isj20193658 ◽

2019 ◽

Vol 6 (9) ◽

pp. 3111

Author(s):

Mahim Koshariya ◽

Sheikh Behram ◽

Jay Prakash Singour ◽

Shashikant Tiwari ◽

Vidhu Khare

Keyword(s):

Cystic Duct ◽

Hepatic Duct ◽

Anatomical Variation ◽

Clinical Importance ◽

Biliary Tree ◽

Cystic Artery ◽

Common Hepatic Duct ◽

Left Hepatic Duct ◽

Extrahepatic Biliary Tree ◽

Insight Into

Background: Congenital anamolies of extrahepatic biliary apparatus and pancreas have long been recognized and are of clinical importance because when present may surprise the surgeon during surgery and lead to iatrogenic injuries. Surgeries on extra-hepatic biliary apparatus and pancreas are regularly performed throughout the world. Thus insight into the normal anatomy and congenital variations will reduce complication and definitely improve outcome.Methods: Study was conducted in department of surgery GMC Bhopal and dissection was carried out in Department of Forensic Medicine on 100 cadavers with approval from ethical committee.Results: In 100 cases 70 were male and 30 female. The most common variation in extra hepatic biliary apparatus was short cystic duct was found in 6% cases then formation of common hepatic duct by union of right hepatic duct and left hepatic duct was intrahepatic in 3% cases. There was low insertion of cystic duct with common hepatic duct in 1% case. Cystic artery originating from left hepatic artery in 1% case, in 1% case cystic artery was anterior to common hepatic duct. In Pancreas anterior arterial arcade was absent in 2% cases and its origin varied in 2% case. Posterior pancreatic arcade absent in 1% cases and variation in origin was present in 1% case. The variation in pancreatic duct course was present in 22% cases.Conclusions: Thus significant variation was seen and it could definitely be helpful to hepatobiliary, laproscopic surgeons, radiologist and will further contribute to literature on variation of extrahepatic biliary apparatus and pancreas and its related vessels.

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Granular Cell Tumor at the Hepatic Duct Confluence Mimicking Klatskin Tumor

Digestive Surgery ◽

10.1159/000018858 ◽

2000 ◽

Vol 17 (3) ◽

pp. 299-303 ◽

Cited By ~ 16

Author(s):

Dennis S. te Boekhorst ◽

Michael F. Gerhards ◽

Thomas M. van Gulik ◽

Dirk J. Gouma

Keyword(s):

Granular Cell Tumor ◽

Hepatic Duct ◽

Granular Cell ◽

Cell Tumor ◽

Klatskin Tumor

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Endobronchial granular cell tumor mimicking asthma

IP Indian Journal of Immunology and Respiratory Medicine ◽

10.18231/j.ijirm.2021.043 ◽

2021 ◽

Vol 6 (3) ◽

pp. 201-203

Author(s):

Subhajit Sen ◽

Pratik Biswas

Keyword(s):

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Benign Tumors ◽

Endobronchial Growth

The article presents a 22 year old female being treated as a case of asthma without any benefit, whom was ultimately found to have an endobronchial growth which on biopsy revealed Granular Cell Tumor. Pulmonary Granular Cell Tumors are very rare benign tumors as less than 80 cases has been described since 1938, when it was first described.

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Obstructive jaundice due to acute acalculous cholecystitis: ‘Mirizzi-like syndrome’

BMJ Case Reports ◽

10.1136/bcr-2020-239564 ◽

2021 ◽

Vol 14 (3) ◽

pp. e239564

Author(s):

Takashi Sakamoto ◽

Alan Kawarai Lefor ◽

Tetsuro Takasaki

Keyword(s):

Obstructive Jaundice ◽

Hepatic Duct ◽

Acalculous Cholecystitis ◽

Endoscopic Retrograde Cholangiography ◽

Common Hepatic Duct ◽

Acute Acalculous Cholecystitis ◽

Endoscopic Retrograde ◽

Percutaneous Transhepatic Drainage ◽

Transhepatic Drainage ◽

Duct Stenosis

A 78 year-old female status post subarachnoid haemorrhage developed abdominal pain and obstructive jaundice. CT scan showed acute cholecystitis and dilation of the intrahepatic ducts. Endoscopic retrograde cholangiography revealed hepatic duct stenosis due to compression by an enlarged gallbladder. No stones were seen in the common hepatic duct and the cystic duct was patent. An endoscopic retrograde biliary drain was placed to relieve the obstructive jaundice due to acute acalculous cholecystitis. Percutaneous transhepatic drainage was performed to treat the acute acalculous cholecystitis. Hepatic duct stenosis was improved on endoscopic retrograde cholangiography performed 19 days after percutaneous transhepatic drainage. It may be reasonable to treat ‘Mirizzi-like syndrome’ non-operatively.

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