scholarly journals Giant liver hemangioma in patient with ileal gastrointestinal stromal tumor

2014 ◽  
Vol 67 (1-2) ◽  
pp. 55-59
Author(s):  
Vasilije Antic ◽  
Marjan Micev ◽  
Danijela Baskic ◽  
Violeta Mladenovic
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Surgical Removal ◽  
Liver Hemangioma ◽  
Palpable Mass ◽  
Gastrointestinal Malignancies ◽  
Stromal Tumors ◽  
The Right

Introduction. Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. These tumors represent more than 80% of all mesenchymal tumors found in the gastrointestinal tract, though they account for only approximately 3% of all gastrointestinal malignancies. Literature offers case reports, which describe symptomatic gastrointestinal stromal tumors and they generally represent patients with larger tumors. Case report. We present the case of a small gastrointestinal stromal tumor in a 40-year-old man, with associated giant liver hemangioma and fever, and with history of abdominal discomfort and fever. Clinical examination revealed hepatosplenomegaly, palpable mass in the right lower abdomen, and signs of neurofibromatosis type 1 (Morbus von Recklinghausen). Computed tomography revealed a giant tumor in the right lobe of the liver. Magnetic resonance showed abscess in the hemangioma of the liver. An intestinal tumor was incidentally found and excised during surgical laparotomy. An intestinal gastrointestinal stromal tumor was revealed by histopathology and confirmed by immunohistochemistry. Although a multidisciplinary team proposed surgical removal of the liver tumor mass, the surgeons decided to follow up the patient because of a high risk of new intervention. Conclusion. According to the available data, this is a very rare case of small intestinal gastrointestinal stromal tumor, with symptoms of fever and giant abscess in the liver hemangioma.

scholarly journals Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

2012 ◽  
Vol 6 ◽  
pp. CMO.S9180 ◽  
Author(s):  
Claudio Casella ◽  
Vincenzo Villanacci ◽  
Filippo D'adda ◽  
Manuela Codazzi ◽  
Bruno Salerni
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Radiological Evaluation ◽  
Retroperitoneal Mass ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms ◽  
Paravertebral Region ◽  
Histology And Immunohistochemistry

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. More rarely neoplasms with histology and immunohistochemistry similar to GISTs may occur outside the gastrointestinal tract (omentum, mesentery and retroperitoneum) and are so-called Extra-gastrointestinal Stromal Tumors (EGISTs). EGISTs arising in the retroperitoneum are extremely rare: to date, only 58 cases have been reported in the literature. Case Report We herein report a case of a primary EGIST of the retroperitoneum surgically treated. The pre-operative radiological evaluation showed a retroperitoneal mass, placed in left paravertebral region. Results Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor (intermediate-low risk form). Conclusions As a result of the rarity of reports of primary EGISTs of retroperitoneum we need to analyze the data of reported cases in order to gain a better understanding about the pathogenesis, prognosis and optimal treatment of this disease.

Large Omental Metastases of a Gastrointestinal Stromal Tumor

Medicina ◽  
2011 ◽  
Vol 47 (11) ◽  
pp. 86
Author(s):  
Povilas Ignatavičius ◽  
Tomas Petraitis ◽  
Žilvinas Saladžinskas ◽  
Lilija Butkevičienė ◽  
Kristina Žvinienė
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Metastatic Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Cells Of Cajal

Gastrointestinal stromal tumors are rare tumors, originating from the interstitial cells of Cajal. They are the most common mesenchymal tumors of the gastrointestinal tract. Metastatic tumor is treated with imatinib mesylate. A case of large metastases of a gastrointestinal stromal tumor to the omentum, diagnosis and treatment principles are presented in this case report.

scholarly journals Giant gastrointestinal stromal tumor of ileum: the gist of GIST: a case report

2017 ◽  
Vol 4 (3) ◽  
pp. 1096
Author(s):  
M. S. Ray ◽  
B. S. Deepak
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Standard Of Care ◽  
Clinical Situation ◽  
Stromal Tumor ◽  
Curative Therapy ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms

Gastrointestinal stromal tumors (GIST) are relatively rare pathology as compared with other mitotic lesions of GIT. However, GIST is the most common mesenchymal neoplasms of the gastrointestinal tract. Biopsy of the lesion and Immuno-Histo-Chemistry (IHC) for CD117 confirms the diagnosis. Surgery remains the standard of care and only potentially curative therapy for patients with primary, resectable, localized gastrointestinal stromal tumor. However, chemotherapy with Imatinib is added in neoadjuvant or adjuvant form according to clinical situation, and histopathological status of the lesion.

scholarly journals Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature

2017 ◽  
Vol 5 ◽  
pp. 2050313X1774631 ◽  
Author(s):  
Haneen Al-Maghrabi ◽  
Abdelrazak Meliti
Keyword(s):  
Case Report ◽  
Bone Formation ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Gastric Wall ◽  
Stromal Tumor ◽  
Osseous Metaplasia ◽  
Gastrointestinal Malignancies ◽  
Stromal Tumors ◽  
Mature Bone

Gastrointestinal stromal tumors are the most common primary mesenchymal tumors of the gastrointestinal tract accounting for 0.1%–3.0% of all gastrointestinal malignancies. The stomach is the most common site (60%) followed by the small bowel (30%–35%) particularly jejunum and ileum, colorectum (5%) and rarely affect esophagus and appendix. Most gastrointestinal stromal tumors arise sporadically, however, less commonly they develop in association with various clinical syndromes like Carney triad, Carney–Stratakis syndrome, familial gastrointestinal stromal tumor syndrome and neurofibromatosis type1 (NF1). We report a 65-year-old male patient presented with gastric mass (7.5 × 4.5 × 3.5 cm) arising from the posterior gastric wall. Histologic examination revealed neoplastic proliferation of spindled and epithelioid cells with focal plexiform pattern and low mitotic activity 3/50 HPF. No evidence of cytological atypia, abnormal mitosis or necrosis. Interestingly enough, there were focal areas of mature bone formation/osseous differentiation associated with calcification. The tumor cells were strongly positive for CD117, DOG1 with focal immunoreactivity against CD34. The morphologic features and the immunoprofile were diagnostic of gastrointestinal stromal tumor. Herein, we present a rare case of gastric gastrointestinal stromal tumor with mature bone formation, osseous metaplasia and calcification. To the best of our knowledge, this is the second case report of gastric gastrointestinal stromal tumor with osseous differentiation and mature bone formation.

scholarly journals Extra-Gastrointestinal retroperitoneal giant stromal tumor complicated with intra-tumoral hemorrhage: case report and literature review

2015 ◽  
Vol 21 (1) ◽  
pp. 1-6
Author(s):  
B.A. Suciu ◽  
V. Bud ◽  
Doina Milutin ◽  
Ioana Halmaciu ◽  
C. Constantin ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Literature Review ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Stromal Tumors ◽  
Pathological Characteristics ◽  
Mesenchymal Origin ◽  
Extragastrointestinal Stromal Tumor

Abstract Gastrointestinal stromal tumors are an uncommon sarcomas with mesenchymal origin that arises in the gastrointestinal tract. Recently, most of the published reports describe such tumors located outside of the gastrointestinal tract, with similar pathological characteristics and are named extra-gastrointestinal stromal tumors. We report the case of a patient suffering for a giant retroperitoneal extra-gastrointestinal stromal tumor, complicated with intra-tumoral hemorrhage. The particularity of this case is the presence of the intra-tumoral hemorrhage in a retroperitoneal extragastrointestinal stromal tumor that grew rapidly in volume (in 1 week).

Liver metastasis from pancreatic gastrointestinal stromal tumor presenting 5 years after resection: a rare case with management challenges

2018 ◽  
pp. 1-3
Keyword(s):  
Gastrointestinal Tract ◽  
High Risk ◽  
Liver Metastasis ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Uncinate Process ◽  
Stromal Tumor ◽  
Distal Common Bile Duct ◽  
Stromal Tumors ◽  
Whipple’S Procedure

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising from the gastrointestinal tract. Stromal tumors arising outside the gastrointestinal tract are called extra-gastrointestinal stromal tumors, usually found in omentum, mesentery, retroperitoneum and gallbladder. We report a case of 31 years old male with 3-month history of painless jaundice and undocumented weight loss. Computerized tomography scan showed a well-defined, rounded enhancing lesion in the uncinate process of pancreas measuring 53x49mm compressing the distal common bile duct. Percutaneous biopsy confirmed gastrointestinal stromal tumor. He underwent Whipple’s procedure followed by adjuvant imatinib due to high-risk features. He remained well for a long time and developed oligo-metastasis in liver 5 years after resection while he was still on imatinib. The patient underwent hepatic resection and remains well one year after the second resection on adjuvant treatment. Pancreatic extragastrointestinal stromal tumor involving uncinate process is a rare disease entity. First line of management is negative margin resection followed by adjuvant therapy with imatinib for high-risk tumors. In case of resectable liver metastasis, resection of metastasis followed by multimodal therapy seems to prolong the disease free and overall survival.

scholarly journals Extra - Intestinal Gastrointestinal Stromal Tumor of Omentum

2014 ◽  
Vol 4 (8) ◽  
pp. 682-684
Author(s):  
S Basnet ◽  
A Lakhey
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Rare Case ◽  
Stromal Tumor ◽  
Malignant Neoplasms ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Rare Tumors

Gastrointestinal stromal tumors are rare tumors, constituting less than 3% of all gastrointestinal malignant neoplasms but are the most common mesenchymal tumors of the gastrointestinal tract. Approximately 10% of gastrointestinal stromal tumors are extraintestinal and mostly arise from the mesentery or omentum. Here we report a rare case of an extraintestinal gastrointestinal stromal tumor of mesentery. Morphological and immunohistochemical features led to a diagnosis of extra-gastrointestinal stromal tumor.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11610 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 682-684

scholarly journals Massive hemorrhage of upper gastrointestinal tract caused by gastrointestinal stromal tumor of the stomach: Case report

2012 ◽  
Vol 65 (7-8) ◽  
pp. 341-345
Author(s):  
Nenad Lalovic ◽  
Nikolina Dukic-Vladicic ◽  
Radmil Maric ◽  
Mirjana Cuk ◽  
Milan Simatovic ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Digestive System ◽  
Massive Hemorrhage ◽  
Stromal Tumor ◽  
Acute Bleeding ◽  
Stromal Tumors ◽  
Upper Gastrointestinal

Introduction. Acute bleeding from the upper gastrointestinal system is a medical emergency which is followed by high mortality rate, ranging from 6 to 15% in spite of modern diagnostic methods and treatment. Bleeding from the upper gastrointestinal system may be caused by gastrointestinal stromal tumors of the stomach, which are mainly characterized by occult bleeding, while profuse bleeding rarely occurs accompanied by hemorrhagic shock. Gastrointestinal stromal tumors of stomach are the most common mesenchimal tumors of the gastrointestinal tract. Case Report. In our study we showed a 60-year-old female patient with profuse bleeding from the stomach and the clinical picture of severe hemorrhagic shock, caused by gastrointestinal stromal tumor. An ovoid junction, raised towards the lumen, covered with ulcerated mucosa in several places and followed by massive arterial bleeding was found intraoperatively, after the performed gastrotomy. Histopathological examination with immunohistochemical analysis confirmed that this was a gastrointestinal stromal tumor of the stomach. Discussion. Acute bleeding from the digestive system is a sudden and serious condition of the body. Urgent esophagogastroduodenoscopy is a sensitive and specific diagnostic and therapeutic method of choice. Massive bleeding from the upper gastrointestinal tract is very rarely caused by gastrointestinal stromal tumors, whose clinical picture is very heterogeneous and depends on tumor size and location. Abundant bleeding from the tumor is an indication for urgent surgical intervention. Conclusion. According to the literature massive hemorrhage of the upper digestive system can rarely be caused by gastrointestinal stromal tumor of the stomach. It is shown that abundant hemorrhage of the upper digestive tract can be caused with gastric gastrointestinal stromal tumor. Surgical resection is the main form of treatment of gastrointestinal stromal tumors of the digestive system and bleeding from these tumors caused by failure of endoscopic hemostasis.

scholarly journals Gastrointestinal stromal tumor of rectum

2019 ◽  
Vol 19 (2) ◽  
pp. 85-88
Author(s):  
Md Rayhanur Rahman ◽  
Md Shahadot Hossain Sheikh ◽  
Ismat Jahan Lima ◽  
Most Bilkis Fatema ◽  
Md Ariful Alam ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
High Risk ◽  
Gastrointestinal Stromal Tumor ◽  
Surgical Resection ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Intermediate Risk ◽  
Stromal Tumors ◽  
Rectal Gist ◽  
Complete Surgical Resection

Although gastrointestinal stromal tumors (GISTs) frequently occur in the gastrointestinal tract, they are relatively rare in the rectum. Biopsy of the lesion and immunohistochemistry (IHC) confirm the diagnosis. Complete surgical resection is the principal curative procedure. In combination with surgery, immunotherapy with Imatinib shows cure in intermediate risk and improvement in high risk rectal GIST. We report a case of a 45-yearold female who  presented with constipation and generalized weakness, ultimately diagnosed to have rectal GIST. Journal of Surgical Sciences (2015) Vol. 19 (2) : 85-88

scholarly journals Local resection of gastrointestinal stromal tumor of the second part of duodenum

2010 ◽  
Vol 50 (180) ◽  
Author(s):  
R Kansakar ◽  
S Adhikari
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Transverse Colon ◽  
Gastrointestinal Stromal Tumors ◽  
Local Resection ◽  
Stromal Tumor ◽  
Segmental Resection ◽  
Stromal Tumors

Gastrointestinal stromal tumors are relatively rare in the duodenum, representing 2-4% of Gastrointestinal stromal tumors of the gastrointestinal tract. We describe a huge Gastrointestinal stromal tumor arising from the second part of the duodenum invading the transverse colon which was removed successfully by local resection of the second part of the duodenum along with a segment of transverse colon. Keywords: duodenum, gastrointestinal stromal tumor, segmental resection

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