complete surgical resection
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Author(s):  
Gustavo F C Fagundes ◽  
Madson Q Almeida

Abstract Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from chromaffin cells of the adrenal medulla or extra-adrenal paraganglia, respectively. PPGLs have the highest degree of heritability among endocrine tumors. Currently, ~40% of PPGL individuals have a genetic germline and there exist at least 12 different genetic syndromes related to these tumors. Metastatic PPGLs are defined by the presence of distant metastases at sites where chromaffin cells are physiologically absent. Approximately 10% of pheochromocytomas and ~40% of sympathetic paragangliomas are linked to metastases explaining why complete surgical resection is the first-choice treatment for all PPGL patients. The surgical approach is a high-risk procedure requiring perioperative management by a specialized multidisciplinary team in centers with broad expertise. In this review, we summarize and discuss the most relevant aspects of perioperative management in patients with pheochromocytomas and sympathetic paragangliomas.


Author(s):  
Maryam Hammad ◽  

Mesenteric cysts are rare, variably-sized intra-abdominal lesions developing during childhood. Their symptoms vary from being asymptomatic and incidentally found to non-specific, presenting as lower abdominal pain, nausea and vomiting, constipation and diarrhea. Clinically, these abdominal masses may be palpable in more than 50% of patients. The diagnosis of these lesions can be made accurately radiologically through abdominal ultrasound and CT. The treatment of choice is complete surgical resection. Hereby we report the clinical course of a 5 year old child with a mesenteric cyst who complained of acute abdominal pain, constipation and vomiting and were surgically treated after being diagnosed with a mesenteric cyst based on radiological examination.


Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 859-861
Author(s):  
Deviprasad Dosemane ◽  
Cheryl Sarah Philipose ◽  
Deepa Adiga ◽  
Meera Niranjan Khadilkar ◽  
Sanchit Bajpai

A recurrent mass in the nose can pose diagnostic and therapeutic challenges. Even more so, if it exhibits rapid growth, displays unusual clinical features, is a rare histopathological diagnosis or if the patient is unavailable for regular follow-up. We present a case of a middle-aged retrovirus-positive man who underwent surgical removal of a recurrent nasal mass. Histopathology revealed a diagnosis of low-grade fibromyxoid sarcoma, a rare entity in the sinonasal tract. Immunohistochemistry plays a crucial role in clinching the diagnosis, especially for lesions with fibrous and myxoid components. Early and complete surgical resection diminishes the likelihood of recurrence and metastasis.  


2021 ◽  
Vol 9 (1) ◽  
pp. 181
Author(s):  
Aws Abdulrahman Alsuhaibani ◽  
Abdullah Abdulrahman Alsuhaibani ◽  
Tareq Salah Hassan

Insulinoma is the most common pancreatic neuroendocrine tumor (NET). It is a rare disease account for 1-2% of pancreatic tumors and affect approximately up to 3 patients per million per year. complete surgical resection or debulking are standard of care option. However, surgery is associated with short and long-term post-operative morbidity and may not be appropriate for all patients. In This case we present management and cure of a case of functioning insulinoma with stereotactic ablative radiosurgery in an unfit patient for surgery.


2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Maha Alkhattab ◽  
Amenah Dhannoon ◽  
Rishabh Sehgal ◽  
Conor Gormley ◽  
Margaret Sheehan ◽  
...  

Schwannomas are rare mesenchymal tumors. They are usually diagnosed incidentally during endoscopic or diagnostic imaging for another reason. Malignant transformation is rare. In this case report, we present an incidental schwannoma protruding through the appendiceal orifice diagnosed during endoscopy. A healthy 56-year-old female underwent a surveillance colonoscopy for family history of colorectal cancer. A prominent and edematous appendiceal orifice was noted, and the area was aggressively biopsied. Histopathological assessment revealed a benign schwannoma. Computerized topography was unremarkable. Subsequently, the patient underwent a right hemicolectomy. Patient is scheduled to undergo routine surveillance in three years. Grossly, schwannomas are white, encapsulated, and well-circumscribed lesions that stain strongly positive for S100, GFAP, and CD57. Histologically, schwannomas demonstrate spindle cell proliferation. Several imaging modalities have been utilized in the diagnosis and management of mesenchymal neoplasms. Despite the benign nature of the diagnosis, complete surgical resection with clear margins remains the gold standard management strategy. Our case highlights the presence of a relatively uncommon tumor in an unusual anatomical location.


Author(s):  
anju shrestha ◽  
Hari Dhakal ◽  
Sirish Pandey ◽  
Kapendra Amatya ◽  
Sudip Shrestha ◽  
...  

We present two cases of nine and twenty-seven years old girls with recurrence of immature teratoma after an incomplete surgical staging. In both cases, there were huge abdominopelvic masses despite decrease in tumor markers with chemotherapy. Complete surgical resection of these masses was done, and histopathology showed only mature teratoma.


2021 ◽  
Vol 6 (12) ◽  

We present a young adult male patient with chronic Hidradenitis Suppurativa (HS) stage Ⅱ-Ⅲ, mostly involving buttocks, thighs and perineum. The patient has been followed initially by a dermatologist for 2 years with trials of Biologic treatments. The ongoing purulent discharges made him quite dysfunctional. Patient was offered a definitive and extensive surgical option. Considering this conditions’ devastating social, psychological effects, such patients should be managed with a multidisciplinary team, elaborated education and counseling. Initial line of treatment plans should be considered as preparatory to the definitive surgical excisional therapy. Patient’s acceptance to the entire package that goes with the definitive surgery is fundamental for a successful and lasting outcome. Complete surgical resection of the disease and reconstruction remains to be the only available option for cure in a fully established HS.


2021 ◽  
Vol 8 (12) ◽  
pp. 3702
Author(s):  
Maria C. Gonçalves ◽  
Inês C. Gonçalves ◽  
Mafalda Salvado ◽  
Sara Diniz

Gallbladder cancer is the 5th most common gastrointestinal cancer, is 2-3 times more frequent in females, and gallstones represent the most important association with this type of cancer. It is generally diagnosed incidentally after cholecystectomy for cholelithiasis and complete surgical resection offers the only potential cure. We report a case of a 42-year-old female, previously healthy, with upper right quadrant pain for 2 weeks and an ultrasound suggestive of cholecystitis. Unfortunately, intraoperative findings were discouraging.


Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5843
Author(s):  
Chonji Fukumoto ◽  
Ryo Oshima ◽  
Yuta Sawatani ◽  
Ryo Shiraishi ◽  
Toshiki Hyodo ◽  
...  

Background: The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate methods during the period in which latent/dormant cancer cells become more apparent. To investigate the appropriate surveillance of patients with OSCC based on the individual risk for recurrence and/or metastasis, we performed a retrospective cohort study after the complete surgical resection of OSCC as the primary treatment. Methods: The study was performed in 324 patients with OSCC who had been primarily treated with surgery from 2007 to 2020 at our hospital. We investigated the period, timing, and methods (visual examination, palpation and imaging using FDG-PET/CT or CECT) for surveillance in each case that comprised postsurgical treatment. Results: Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node metastasis, and distant metastasis occurred within 200 days, and 75% of all of these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected earlier by imaging examinations than they were by visual examination and palpation. Conclusions: For the surveillance of patients with OSCC after primary surgery, it is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on individual risk assessment.


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