Using data from the Integrated Public Use Microdata Series (IPUMS), this analysis examines the economic activity of black and white southern-born female migrants participating in the Great Migration. Labor force participation and occupational SEI scores are investigated with specific focus on racial differences within and between migrant groups. Black migrants had a higher probability of participating in the labor force, yet their employment was concentrated among the lower SEI occupations throughout the period. Racial differences also were observed among the influence of personal, household, and location characteristics on economic activity such that the positive associations were less pronounced, while the negative impacts were differentially felt among black migrant women; education was less beneficial, and the deterring effects of marital status were less pronounced for black migrants. Racial differences narrowed at the end of the Great Migration for the southern migrants, reflecting a pattern most similar to nonmigrant northerners and more advantageous than that observed for nonmigrant southern women.