Gene Structure and Function

2018 ◽  
pp. 31-39
Keyword(s):  
Gene Structure ◽  
Structure And Function ◽  
And Function

Gene Structure and Function of Thermophilic ATP Synthase

1989 ◽  
pp. 3-8
Author(s):  
Yasuo Kagawa ◽  
Shigeo Ohta ◽  
Masafumi Yohda ◽  
Hajime Hirata ◽  
Toshiro Hamamoto ◽  
...  
Keyword(s):  
Atp Synthase ◽  
Gene Structure ◽  
Structure And Function ◽  
And Function

Role in Gene Structure and Function

1982 ◽  
pp. 193-221 ◽  
Author(s):  
G.H. GOODWIN ◽  
C.G.P. MATHEW
Keyword(s):  
Gene Structure ◽  
Structure And Function ◽  
And Function

Alteration of p53 gene structure and function in laryngeal squamous cell cancer

1997 ◽  
Vol 254 (S1) ◽  
pp. S133-S137 ◽  
Author(s):  
W. Golusinski ◽  
J. Olofsson ◽  
Z. Szmeja ◽  
K. Szyfter ◽  
W. Szyfter ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Gene Structure ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
P53 Gene ◽  
Structure And Function ◽  
Laryngeal Squamous Cell Cancer ◽  
And Function

Mucin gene structure and expression: protection vs. adhesion

1995 ◽  
Vol 269 (5) ◽  
pp. G613-G627 ◽  
Author(s):  
B. J. Van Klinken ◽  
J. Dekker ◽  
H. A. Buller ◽  
A. W. Einerhand
Keyword(s):  
Molecular Biology ◽  
Gene Structure ◽  
Lymphocyte Activation ◽  
Structure And Function ◽  
Lymphocyte Homing ◽  
Major Step ◽  
Molecular Analyses ◽  
Specific Receptors ◽  
Gene Structure And Expression ◽  
And Function

The cloning of mucin cDNAs brought about by the application of molecular biology and molecular analyses constitutes a major step in understanding mucin structure and function. Here two classes of mucins are described: epithelium-associated and endothelium/leukocyte-associated mucins, which have thus far been described separately in the literature. The epithelial mucins are generally believed to play a role in cytoprotection. The endothelial and leukocyte class of mucins are adhesion molecules involved in lymphocyte homing and lymphocyte activation or are part of the adhesion cascade that plays a role in the initiation of inflammation. Mucins in general contain many threonine and serine residues, which are extensively O-glycosylated. Due to this profound glycosylation, mucins have a filamentous conformation. By virtue of their extended filamentous, and often negatively charged, structure, mucins can act as a barrier protecting the cell. However, when an opposing cell has specific receptors for mucins, adhesion can override the barrier function. Therefore, mucins may be powerful two-edged swords: they are both protective and adhesive.

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