The Future of Transplant Biology and Surgery

2018 ◽  
Author(s):  
Marc Colaco ◽  
Anthony Atala
Keyword(s):  
Regenerative Medicine ◽  
Large Scale ◽  
Three Dimensional ◽  
Organic Substrates ◽  
Experimental Phase ◽  
Three Dimensional Printing ◽  
The Future ◽  
Technological Developments ◽  
Synthetic Scaffolds ◽  
Dimensional Printing

Although allograft organs remain the gold standard for transplantation, the availability of donor organs has forced us to search for alternatives. Regenerative medicine and tissue engineering offer a solution for this issue. Through the use of synthetic scaffolds and organic substrates, we have been able to generate neoorgans for a variety of different body systems. Although these neoorgans remain largely in the experimental phase, the results are promising, and recent technological developments have made production a realistic endeavor on the large scale. In this review, we highlight recent advances in the field of regenerative medicine and their application to the future of transplant surgery.  This review contains 6 figures, 2 tables and 42 references Key Words: bioengineering, biomaterial, bioreactor, decellularized organs, organ scaffolds, regenerative medicine, stem cell, three-dimensional printing

Do You Own Your 3D Bioprinted Body?

2015 ◽  
Vol 41 (1) ◽  
pp. 167-189 ◽  
Author(s):  
Jeremy Thomas Harbaugh
Keyword(s):  
Regenerative Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
The United States ◽  
Three Dimensional Printing ◽  
Organ Donations ◽  
Human Use ◽  
Transplant Candidates ◽  
Dimensional Printing

By the end of 2013, almost 122,000 organ transplant candidates in the United States remained active on the national waiting list. The current number of candidates exceeds 123,000. To address this overwhelming need, researchers have been exploring methods to supplement traditional organ donations. At the forefront of this research is regenerative medicine, the field of regenerating or replacing tissue and organ function by studying the body’s own healing mechanisms. Regenerative medicine is quickly fulfilling its promise of producing vascularized, functioning organs in vitro by combining two other areas of research: the replication of cell lines in vitro and the recent adaptation of three-dimensional printing for the health care industry. Today, physicians armed with the latest generation of bioprinters and imaging equipment are creating high-resolution airway splints and personalized bone replacements for human use. These techniques have even achieved success with more complicated structures, including human kidneys and livers.

Bioinks for Three-Dimensional Printing in Regenerative Medicine

2019 ◽  
pp. 805-830 ◽  
Author(s):  
Javier Navarro ◽  
Gisele A. Calderon ◽  
Jordan S. Miller ◽  
John P. Fisher
Keyword(s):  
Regenerative Medicine ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Dimensional Printing

scholarly journals Adhesion of three-dimensional printing on textile fabrics: Inspiration from and for other research areas

2020 ◽  
Vol 15 ◽  
pp. 155892502091087 ◽  
Author(s):  
Tomasz Kozior ◽  
Tomasz Blachowicz ◽  
Andrea Ehrmann
Keyword(s):  
Experimental Research ◽  
Large Scale ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Research Areas ◽  
Polymer Adhesion ◽  
Textile Fabrics ◽  
Main Challenge ◽  
Theoretical Investigations ◽  
Dimensional Printing

Combining textile fabrics with three-dimensional printed items can be a good approach to save time and money as compared with purely three-dimensional printed large-scale objects, to reach desired position-dependent mechanical properties, for design and technological purposes. The main challenge in such bi-material systems is the adhesion between both partners of the composites. Although some experimental research on this topic has been performed during the last years, only few theoretical investigations exist which may support striving for material combinations with higher adhesion. Here, we give an overview of the recent state of experimental research on adhesion in textile/polymer composites as well as of theoretical investigations on adhesion inside the three-dimensional printed part. Combining both topics, we suggest further research approaches to increase the textile/polymer adhesion.

Effects of mixture ingredients on interlayer adhesion of concrete in Contour Crafting

2018 ◽  
Vol 24 (3) ◽  
pp. 584-592 ◽  
Author(s):  
Babak Zareiyan ◽  
Behrokh Khoshnevis
Keyword(s):  
Empirical Model ◽  
Design Methodology ◽  
Large Scale ◽  
Three Dimensional ◽  
Content Type ◽  
Three Dimensional Printing ◽  
Contour Crafting ◽  
Model Condition ◽  
Dimensional Printing ◽  
Significant Factors

Purpose This paper aims to investigate the strength at interlayer of specimens fabricated using Contour Crafting (CC) to develop a concrete mixture for large-scale three-dimensional printing. Design/methodology/approach The collected data from several experiments were analyzed to understand significant factors and their interactions. After developing the empirical model, condition for maximum desirability was identified and the model was validated. Findings The experimental investigation of varied combination of concrete components introduced an empirical model which can predict the strength at interface. Moreover, an optimized mixture within constrains of the CC nozzle was developed and validated. Originality/value Several experimental samples were tested, and the derived empirical model was validated after more than 600 h of work.

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