Biological Significance of Site-specific Transformation of Chondrocytes in Mouse Meckel’s Cartilage

2010 ◽  
Vol 52 (2) ◽  
pp. 136-142
Author(s):  
Kiyoto Ishizeki ◽  
Tadayoshi Kagiya ◽  
Naoki Fujiwara ◽  
Keishi Otsu ◽  
Hidemitsu Harada
Keyword(s):  
Biological Significance ◽  
Site Specific ◽  
Meckel's Cartilage ◽  
Meckel’S Cartilage

Biological Significance of Site-specific Transformation of Chondrocytes in Mouse Meckel's Cartilage

2010 ◽  
Vol 52 (2) ◽  
pp. 136-142 ◽  
Author(s):  
Kiyoto Ishizeki ◽  
Tadayoshi Kagiya ◽  
Naoki Fujiwara ◽  
Keishi Otsu ◽  
Hidemitsu Harada
Keyword(s):  
Biological Significance ◽  
Site Specific ◽  
Meckel's Cartilage ◽  
Meckel’S Cartilage

scholarly journals Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition

2021 ◽  
Vol 8 (11) ◽  
Author(s):  
Richard P. Dearden ◽  
Sam Giles
Keyword(s):  
Conveyor Belt ◽  
Major Obstacle ◽  
Site Specific ◽  
Meckel's Cartilage ◽  
Jaw Bones ◽  
Lateral Edge ◽  
Meckel’S Cartilage ◽  
Independent Origin ◽  
Bony Fishes ◽  
Dermal Bone

The teeth of sharks famously form a series of transversely organized files with a conveyor-belt replacement that are borne directly on the jaw cartilages, in contrast to the dermal plate-borne dentition of bony fishes that undergoes site-specific replacement. A major obstacle in understanding how this system evolved is the poorly understood relationships of the earliest chondrichthyans and the profusion of morphologically and terminologically diverse bones, cartilages, splints and whorls that they possess. Here, we use tomographic methods to investigate mandibular structures in several early branching ‘acanthodian’-grade stem-chondrichthyans. We show that the dentigerous jaw bones of disparate genera of ischnacanthids are united by a common construction, being growing bones with non-shedding dentition. Mandibular splints, which support the ventro-lateral edge of the Meckel's cartilage in some taxa, are formed from dermal bone and may be an acanthodid synapomorphy. We demonstrate that the teeth of Acanthodopsis are borne directly on the mandibular cartilage and that this taxon is deeply nested within an edentulous radiation, representing an unexpected independent origin of teeth. Many or even all of the range of unusual oral structures may be apomorphic, but they should nonetheless be considered when building hypotheses of tooth and jaw evolution, both in chondrichthyans and more broadly.

scholarly journals Modulated Expression of Type X Collagen in the Meckel's Cartilage with Different Developmental Fates

1995 ◽  
Vol 170 (2) ◽  
pp. 387-396 ◽  
Author(s):  
Kun Sung Chung ◽  
Howard H. Park ◽  
Kang Ting ◽  
Hiroko Takita ◽  
Suneel S. Apte ◽  
...  
Keyword(s):  
Type X Collagen ◽  
Meckel's Cartilage ◽  
Meckel’S Cartilage

scholarly journals Functional analysis of CTRP3/cartducin in Meckel’s cartilage and developing condylar cartilage in the fetal mouse mandible

2011 ◽  
Vol 218 (5) ◽  
pp. 517-533 ◽  
Author(s):  
Tamaki Yokohama-Tamaki ◽  
Takashi Maeda ◽  
Tetsuya S. Tanaka ◽  
Shunichi Shibata
Keyword(s):  
Functional Analysis ◽  
Condylar Cartilage ◽  
Meckel's Cartilage ◽  
Fetal Mouse ◽  
Meckel’S Cartilage

Effect of Biomechanical Environment on Degeneration of Meckel’s Cartilage

2020 ◽  
pp. 002203452096011
Author(s):  
M. Farahat ◽  
G.A.S. Kazi ◽  
E.S. Hara ◽  
T. Matsumoto
Keyword(s):  
Endochondral Ossification ◽  
Biomechanical Properties ◽  
Cartilage Degradation ◽  
Middle Region ◽  
Meckel's Cartilage ◽  
3 Dimensional ◽  
Meckel’S Cartilage ◽  
Surrounding Environment ◽  
Rigid Environment

During orofacial tissue development, the anterior and posterior regions of the Meckel’s cartilage undergo mineralization, while the middle region undergoes degeneration. Despite the interesting and particular phenomena, the mechanisms that regulate the different fates of Meckel’s cartilage, including the effects of biomechanical cues, are still unclear. Therefore, the purpose of this study was to systematically investigate the course of Meckel’s cartilage during embryonic development from a biomechanical perspective. Histomorphological and biomechanical (stiffness) changes in the Meckel’s cartilage were analyzed from embryonic day 12 to postnatal day 0. The results revealed remarkable changes in the morphology and size of chondrocytes, as well as the occurrence of chondrocyte burst in the vicinity of the mineralization site, an often-seen phenomenon preceding endochondral ossification. To understand the effect of biomechanical cues on Meckel’s cartilage fate, a mechanically tuned 3-dimensional hydrogel culture system was used. At the anterior region, a moderately soft environment (10-kPa hydrogel) promoted chondrocyte burst and ossification. On the contrary, at the middle region, a more rigid environment (40-kPa hydrogel) enhanced cartilage degradation by inducing a higher expression of MMP-1 and MMP-13. These results indicate that differences in the biomechanical properties of the surrounding environment are essential factors that distinctly guide the mineralization and degradation of Meckel’s cartilage and would be valuable tools for modulating in vitro cartilage and bone tissue engineering.

scholarly journals Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis

Development ◽  
2020 ◽  
Vol 147 (11) ◽  
pp. dev190488 ◽  
Author(s):  
Ceilidh Marchant ◽  
Peter Anderson ◽  
Quenten Schwarz ◽  
Sophie Wiszniak
Keyword(s):  
Meckel's Cartilage ◽  
Meckel’S Cartilage

Autophagy Prior to Chondrocyte Cell Death During the Degeneration of Meckel's Cartilage

2012 ◽  
Vol 295 (5) ◽  
pp. 734-741 ◽  
Author(s):  
Rong-Tao Yang ◽  
Chi Zhang ◽  
Yong Liu ◽  
Hai-Hua Zhou ◽  
Zu-Bing Li
Keyword(s):  
Cell Death ◽  
Meckel's Cartilage ◽  
Meckel’S Cartilage
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