scholarly journals Recovery of Endogenous  -Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation

Diabetes ◽  
2008 ◽  
Vol 58 (2) ◽  
pp. 442-447 ◽  
Author(s):  
R. Bottino ◽  
A. Criscimanna ◽  
A. Casu ◽  
J. He ◽  
D. J. Van der Windt ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Nonhuman Primates ◽  
Cell Function ◽  
Chemical Diabetes ◽  
Diabetes Induction

CGM Shows Islet Transplantation Prevents Hypoglycemia, Correcting Time in Range and Reducing Glycemic Variability, Despite Subnormal Beta-Cell Function

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 143-OR ◽  
Author(s):  
SHAREEN FORBES ◽  
TOLU OLUTOYIN OLATEJU ◽  
ANNA LAM ◽  
JOHN CASEY ◽  
JOHN CAMPBELL ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Transplantation ◽  
Beta Cell Function ◽  
Cell Function ◽  
Glycemic Variability ◽  
Time In Range

Effect of Exenatide on ?? Cell Function After Islet Transplantation in Type 1 Diabetes

2007 ◽  
Vol 83 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Khalid Al Ghofaili ◽  
Michelle Fung ◽  
Ziliang Ao ◽  
Mark Meloche ◽  
R Jean Shapiro ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Transplantation ◽  
Cell Function

scholarly journals Subcutaneous Transplantation of Islets into Streptozocin-Induced Diabetic Rats

2005 ◽  
Vol 14 (8) ◽  
pp. 595-605 ◽  
Author(s):  
Craig R. Halberstadt ◽  
Deana Williams ◽  
Dwaine Emerich ◽  
Moses Goddard ◽  
Alfred V. Vasconcellos ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Cell Function ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
Pancreatic Islet Transplantation ◽  
Minimally Invasive Surgical Procedure ◽  
Minimally Invasive Surgical ◽  
Ease Of Access ◽  
Syngeneic Islet Transplantation ◽  
Type 1 Diabetic Patients

Pancreatic islet transplantation into type 1 diabetic patients is currently being performed by intraportal infusion. This method, albeit reproducible, has some disadvantages including potential development of portal hypertension, hemorrhage, and an inability to retrieve or detect the transplanted tissue. Other transplant sites have been examined in animal models including the omentum, peritoneal cavity, and the spleen. A transplant site that has not been successful in supporting functional islet tissue transplantation in humans is the subcutaneous space due primarily to the lack of a well-defined vascular bed. This site has many favorable characteristics such as ease of access for transplantation and potential for removal of the transplanted tissue with a minimally invasive surgical procedure. This report addresses the evaluation of a subcutaneously placed device for the support of rat syngeneic islet transplantation in a streptozocin-induced diabetic model. The data generated support the use of this device for islet engraftment. In addition, beta cell function in this device compared favorably with the function of islets transplanted to the renal subcapsular space as well as islets within the native pancreas.

scholarly journals Beta-cell function and human islet transplantation: can we improve?

2021 ◽  
Author(s):  
Jennifer Chen ◽  
Jenny E Gunton
Keyword(s):  
Islet Transplantation ◽  
Cell Function ◽  
Therapeutic Option ◽  
Human Islets ◽  
Post Transplantation ◽  
Human Islet Transplantation ◽  
And Function ◽  
Islet Survival

Islet transplantation, a therapeutic option to treat type 1 diabetes, is not yet as successful as whole-pancreas transplantation as a treatment for diabetes. Mouse models are commonly used for islet research. However, it is clear disparities exist between islet transplantation outcomes in mice and humans. Given the shortage of transplant-grade islets, it is crucial that we further our understanding of factors that determine long-term islet survival and function post-transplantation. In turn, that may lead to new therapeutic targets and strategies that to improve transplant outcomes. Here, we summarise the current landscape in clinical transplantation, highlight underlying similarities and differences between mouse and human islets, and review interventions that are being considered to create a new pool of β-cells for clinical application.

FTY720 Treatment Rejuvenates ß-Cell Function and Improves Cardiac Function in Diabetic Nonhuman Primates (NHPs)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1121-P
Author(s):  
YIXIN WANG ◽  
YONGQIANG LIU ◽  
QIAO WEI ◽  
XIAOLI WANG ◽  
GAO SUN ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Nonhuman Primates ◽  
Cell Function

Author response for "Donor insulin use predicts beta‐cell function after islet transplantation"

2020 ◽  
Author(s):  
Iestyn M Shapey ◽  
Angela Summers ◽  
Petros Yiannoullou ◽  
Hussein Khambalia ◽  
Catherine Fullwood ◽  
...  
Keyword(s):  
Beta Cell ◽  
Islet Transplantation ◽  
Beta Cell Function ◽  
Cell Function ◽  
Author Response ◽  
Insulin Use

Preserved beta cell function with insulin treatment in islet transplantation: effect on insulin gene expression

1999 ◽  
Vol 31 (6) ◽  
pp. 2561 ◽  
Author(s):  
M Raurell ◽  
J.F Merino ◽  
V Nacher ◽  
M Biarnés ◽  
J Soler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Beta Cell ◽  
Islet Transplantation ◽  
Beta Cell Function ◽  
Insulin Treatment ◽  
Cell Function ◽  
Insulin Gene ◽  
Insulin Gene Expression

scholarly journals Validation of the BETA ‐2 Score: An Improved Tool to Estimate Beta Cell Function After Clinical Islet Transplantation Using a Single Fasting Blood Sample

2016 ◽  
Vol 16 (9) ◽  
pp. 2704-2713 ◽  
Author(s):  
S. Forbes ◽  
R. A. Oram ◽  
A. Smith ◽  
A. Lam ◽  
T. Olateju ◽  
...  
Keyword(s):  
Beta Cell ◽  
Blood Sample ◽  
Islet Transplantation ◽  
Beta Cell Function ◽  
Cell Function ◽  
Clinical Islet Transplantation ◽  
Beta 2

scholarly journals  -Score: An assessment of  -cell function after islet transplantation

Diabetes Care ◽  
2005 ◽  
Vol 28 (2) ◽  
pp. 343-347 ◽  
Author(s):  
E. A. Ryan ◽  
B. W. Paty ◽  
P. A. Senior ◽  
J. R.T. Lakey ◽  
D. Bigam ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Cell Function

scholarly journals Nonhuman Primate Models of Type 1 Diabetes Mellitus for Islet Transplantation

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Haitao Zhu ◽  
Liang Yu ◽  
Yayi He ◽  
Bo Wang
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Nonhuman Primates ◽  
Experimental Studies ◽  
Animal Models Of Diabetes ◽  
Islet Survival ◽  
New Strategies

Islet transplantation is an attractive treatment of type 1 diabetes mellitus (T1DM). Animal models of diabetes mellitus (DM) contribute a lot to the experimental studies of islet transplantation and to evaluations of isolated islet grafts for future clinical applications. Diabetic nonhuman primates (NHPs) represent the suitable models of DMs to better evaluate the effectiveness of islet transplantation, to assess new strategies for controlling blood glucose (BG), relieving immune rejection, or prolonging islet survival, and eventually to translate the preclinical data into tangible clinical practice. This review introduces some NHP models of DM, clarifies why and how the models should be used, and elucidates the usefulness and limitations of the models in islet transplantation.

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