scholarly journals Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery

Diabetes ◽  
2016 ◽  
Vol 65 (9) ◽  
pp. 2724-2731 ◽  
Author(s):  
Latoya E. Campbell ◽  
Paul R. Langlais ◽  
Samantha E. Day ◽  
Richard L. Coletta ◽  
Tonya R. Benjamin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gastric Bypass ◽  
Human Skeletal Muscle ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Muscle Proteome

scholarly journals Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Samantha E. Day ◽  
Luis A. Garcia ◽  
Richard L. Coletta ◽  
Latoya E. Campbell ◽  
Tonya R. Benjamin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gastric Bypass ◽  
Human Skeletal Muscle ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Sh3 Domain

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery

2015 ◽  
Vol 11 (3) ◽  
pp. 592-601 ◽  
Author(s):  
Emmani B.M. Nascimento ◽  
Isabelle Riedl ◽  
Lake Qunfeng Jiang ◽  
Sameer S. Kulkarni ◽  
Erik Näslund ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gastric Bypass ◽  
Glucose Metabolism ◽  
Human Skeletal Muscle ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

scholarly journals Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals?

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Joseph A. Houmard ◽  
Walter J. Pories ◽  
G. Lynis Dohm
Keyword(s):  
Skeletal Muscle ◽  
Insulin Action ◽  
Human Skeletal Muscle ◽  
Bypass Surgery ◽  
Severe Obesity ◽  
Gastric Bypass Surgery ◽  
Acid Oxidation ◽  
Genetic Origin ◽  
Human Skeletal Muscle Cells ◽  
Severely Obese

Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can “turn off” and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. Physical activity can improve FAO and insulin action, indicating that this patient population is not exercise resistant and that exercise offers a pathway to circumvent the abnormal program. Findings presented in this review will hopefully increase the understanding of and aid in preventing and/or treating the severely obese condition.

Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats

2019 ◽  
Vol 29 (7) ◽  
pp. 2158-2165 ◽  
Author(s):  
Hazel Huang ◽  
Ali Aminian ◽  
Monique Hassan ◽  
Olivia Dan ◽  
Christopher L. Axelrod ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Zucker Diabetic Fatty Rats

GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle

2006 ◽  
Vol 27 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Jung-Jun Park ◽  
Jason R. Berggren ◽  
Matthew W. Hulver ◽  
Joseph A Houmard ◽  
Eric P. Hoffman
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Insulin Action ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Women ◽  
Cross Sectional

Obesity is associated with insulin resistance in skeletal muscle; accordingly, weight loss dramatically improves insulin action. We sought to identify molecular remodeling of muscle commensurate with weight loss that could explain improvements in insulin action. Muscle from morbidly obese women was studied before and after gastric bypass surgery. Gastric bypass surgery significantly reduced body mass by ∼45% and improved insulin action. We then assessed mRNA profiles using a stringent statistical analysis (statistical concordance with three probe set algorithms), with validation in a cross-sectional study of lean ( n = 8) vs. morbidly obese ( n = 8) muscle. Growth factor receptor-bound protein 14 (GRB14), glycerol-3-phosphate dehydrogenase 1 (GPD1), and growth differentiation factor 8 (GDF8; myostatin) significantly decreased ∼2.4-, 2.2-, and 2.4-fold, respectively, after weight loss (gastric bypass). Increased expression of these transcripts was associated with increased obesity in the cross-sectional group (lean vs. morbidly obese muscle). Each transcript was validated by real-time quantitative RT-PCR assays in both study groups. Using Ingenuity Pathway Analysis, we show that all three transcripts are involved in the same regulatory network including AKT1, IGF1, TNF, PPARG, and INS. These results suggest that GRB14, GPD1, and GDF8 are weight loss-responsive genes in skeletal muscle and that the observed transcriptional modulation of these would be expected to improve insulin signaling, decrease triglyceride synthesis, and increase muscle mass, respectively, with weight loss. Thus our data provide a possible regulatory pathway involved in the development of insulin resistance in the morbidly obese state, and improvement of insulin resistance with weight loss.

Abstract #607: Gastric Bypass Surgery is Associated with A Reduction in Vasoconstrictive Mediators

2017 ◽  
Vol 23 ◽  
pp. 124-125
Author(s):  
Paresh Dandona ◽  
Husam Ghanim ◽  
Scott Monte ◽  
Joseph Caruana ◽  
Mayuri Mudgal ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

Gastric Bypass Surgery Improves Liver Diseases

2005 ◽  
Vol 35 (24) ◽  
pp. 53
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Gastric Bypass ◽  
Liver Diseases ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

Gastric bypass surgery for severe obesity

2002 ◽  
Vol 9 (2) ◽  
pp. 79-85 ◽  
Author(s):  
Harvey J. Sugerman
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Severe Obesity ◽  
Gastric Bypass Surgery
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