2026-P: Myeloid Sirtuin 6 Is a Molecular Switch of White Adipose Tissue Browning

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2026-P
Author(s):  
YOUNGYI LEE
Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1944-P
Author(s):  
AOYUAN CUI ◽  
WEITONG SU ◽  
YAQIAN XUE ◽  
ZHENGSHUAI LIU ◽  
FENGGUANG MA ◽  
...  

2020 ◽  
Vol 28 (5) ◽  
pp. 496-501
Author(s):  
Georgia Karpathiou ◽  
Jean Marc Dumollard ◽  
Zoe Evangelou ◽  
Anna Batistatou ◽  
Michel Peoc’h ◽  
...  

White adipose tissue browning has emerged as a putative therapy of obesity, and studies in mice have shown that Cdkn2a is implicated in white-to-brown transition. However, the role of Cdkn2a product p16 has been never studied in human brown fat tissue. The aim of the study is to investigate the expression of p16 in normal brown fat and in hibernoma, a lipoma containing brown fat-like adipocytes. Ten normal brown fat tissues and 5 hibernomas were immunohistochemically studied for p16 expression. Nearby white adipose tissue was used for comparison. All brown fat and hibernomas specimens express p16 in a cytoplasmic manner. Neighboring white adipose tissue is negative for p16 expression. Thus, cytoplasmic p16 may be associated with fat tissue browning.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eun Wha Choi ◽  
Minjae Lee ◽  
Ji Woo Song ◽  
Kyeongdae Kim ◽  
Jungmin Lee ◽  
...  

Adipocyte ◽  
2015 ◽  
Vol 4 (2) ◽  
pp. 146-148 ◽  
Author(s):  
Pu-Ste Liu ◽  
Yi-Wei Lin ◽  
Frank H Burton ◽  
Li-Na Wei

2017 ◽  
Vol 49 (5S) ◽  
pp. 438
Author(s):  
Chen Zheng ◽  
Xiang-Ke Chen ◽  
Chung-Hsin Wu ◽  
Stephen Heung-Sang Wong

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