554-P: Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients with Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 554-P
Author(s):  
LYNN ANG ◽  
KELLEY M. KIDWELL ◽  
JACOB REISS ◽  
BRENDAN R. DILLON ◽  
KARA R. MIZOKAMI-STOUT ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function

Abstract #280: Clusterin and Cardiovascular Autonomic Function: Any Association in Type 2 Diabetes

2016 ◽  
Vol 22 ◽  
pp. 73
Author(s):  
Eyob Makonnen ◽  
Raelene Maser ◽  
M. Lenhard ◽  
Ryan Pohlig
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function

scholarly journals Determinants and Prognostic Value of Cardiovascular Autonomic Function in Coronary Artery Disease Patients With and Without Type 2 Diabetes

Diabetes Care ◽  
2013 ◽  
Vol 37 (1) ◽  
pp. 286-294 ◽  
Author(s):  
Jaana J. Karjalainen ◽  
Antti M. Kiviniemi ◽  
Arto J. Hautala ◽  
Olli-Pekka Piira ◽  
E. Samuli Lepojärvi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Value ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function ◽  
Artery Disease

scholarly journals Osteopontin and osteoprotegerin levels in type 2 diabetes and their association with cardiovascular autonomic function

2016 ◽  
Vol 30 (3) ◽  
pp. 507-510 ◽  
Author(s):  
Raelene E. Maser ◽  
M. James Lenhard ◽  
Ryan T. Pohlig ◽  
P. Babu Balagopal
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function

scholarly journals The Association Between Cardiovascular Autonomic Function and Changes in Kidney and Myocardial Function in Type 2 Diabetes and Healthy Controls

2021 ◽  
Vol 12 ◽  
Author(s):  
Jens Christian Laursen ◽  
Ida Kirstine B. Rasmussen ◽  
Emilie H. Zobel ◽  
Philip Hasbak ◽  
Bernt Johan von Scholten ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Autonomic Function ◽  
Myocardial Function ◽  
Healthy Controls ◽  
Flow Reserve ◽  
Cardiovascular Autonomic Function ◽  
Myocardial Flow ◽  
Valsalva Test

BackgroundThe mechanisms linking cardiovascular autonomic neuropathy, diabetic kidney disease and cardiovascular mortality in type 2 diabetes are widely unknown. We investigated the relationship between baseline cardiovascular autonomic function and changes in kidney and myocardial function over six years in patients with type 2 diabetes and healthy controls.MethodsPost-hoc analysis of a cohort study in 24 patients with type 2 diabetes and 18 healthy controls. Baseline determinants were cardiovascular autonomic reflex tests (heart rate response to: standing (30:15); deep breathing (E:I); and the Valsalva test) and time- and frequency-domain heart rate variability indices. Outcomes were changes in estimated glomerular filtration rate (eGFR), albuminuria, myocardial flow reserve (MFR) measured by cardiac 82Rb Positron emission tomography computed tomography (PET/CT), and coronary artery calcium score (CACS).ResultsMean age at inclusion was 61 ± 10 years and 36% were female. Mean follow up time was 6 ± 0 years. A lower response in heart rate to the Valsalva test (corresponding to weaker autonomic function) was associated with a larger decline in eGFR (p=0.04), but not significantly after adjustment for sex, baseline age, smoking status, systolic blood pressure, heart rate, HbA1c, body mass index and baseline eGFR (p=0.12). A higher baseline response in heart rate to standing (30:15) was associated with a larger decline in myocardial flow reserve in the unadjusted analysis (p=0.02) and after adjustment (p=0.02). A higher response in heart rate to the Valsalva maneuver was associated with a larger increase in CACS (p = 0.02), but the association became insignificant after adjustment (p = 0.16).ConclusionA lower response in heart rate to the Valsalva test was associated with a larger decline in kidney function, indicating that autonomic dysfunction may predict future loss of kidney function. However, we did not find any association between lower values in cardiovascular autonomic function at baseline and a worsening in albuminuria, myocardial function, or atherosclerotic burden.

scholarly journals Cardiovascular autonomic function testing under non-standardised and standardised conditions in cardiovascular patients with type-2 diabetes mellitus

Anaesthesia ◽  
2014 ◽  
Vol 69 (5) ◽  
pp. 476-483 ◽  
Author(s):  
S. W. M. Keet ◽  
C. S. E. Bulte ◽  
A. Sivanathan ◽  
L. Verhees ◽  
C. P. Allaart ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function ◽  
Cardiovascular Patients ◽  
Function Testing

Dapagliflozin and measures of cardiovascular autonomic function in patients with type 2 diabetes (T2D)

2021 ◽  
pp. 107949
Author(s):  
Lynn Ang ◽  
Kelley M. Kidwell ◽  
Brendan Dillon ◽  
Jacob Reiss ◽  
Fang Fang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function
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