850-P: Continued Monitoring of the Foreign-Body Response to Improve Long-Term Success of Macroencapsulation Devices for Type 1 Diabetes: A Proof-of-Concept Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 850-P
Author(s):  
RACHEL M. BEATTY ◽  
EIMEAR B. DOLAN ◽  
SCOTT T. ROBINSON ◽  
RAYMOND OCONNOR ◽  
ROBERT WYLIE ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Foreign Body ◽  
Foreign Body Response ◽  
Proof Of Concept ◽  
Concept Study ◽  
Body Response

Examinations of a new long-term degradable electrospun polycaprolactone scaffold in three rat abdominal wall models

2017 ◽  
Vol 31 (7) ◽  
pp. 1077-1086 ◽  
Author(s):  
Hanna Jangö ◽  
Søren Gräs ◽  
Lise Christensen ◽  
Gunnar Lose
Keyword(s):  
Pelvic Organ Prolapse ◽  
Foreign Body ◽  
Abdominal Wall ◽  
Muscle Fiber ◽  
Pelvic Organ ◽  
Foreign Body Response ◽  
Heavy Load ◽  
Tissue Construct ◽  
Body Response

Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load). After 8 weeks, no animals had developed hernia, and the scaffold provided biomechanical reinforcement, even in the models where it was subjected to heavy load. The scaffold was not yet degraded but showed increased thickness in all groups. Histologically, we found a massive foreign body response with numerous large giant cells intermingled with the fibers of the scaffold. Cells from added muscle fiber fragments could not be traced by PKH26 fluorescence or desmin staining. Taken together, the long-term degradable polycaprolactone scaffold provided biomechanical reinforcement by inducing a marked foreign-body response and attracting numerous inflammatory cells to form a strong neo-tissue construct. However, cells from the muscle fiber fragments did not survive in this milieu. Properties of the new neo-tissue construct must be evaluated at the time of full degradation of the scaffold before its possible clinical value in pelvic organ prolapse surgery can be evaluated.

451-P: Participants’ Satisfaction with the Support Online Self-Guided Educational Platform for Type 1 Diabetes Management: A Proof-of-Concept Study, Preliminary Results

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 451-P
Author(s):  
LI FENG XIE ◽  
CATHERINE LEROUX ◽  
AMÉLIE ROY-FLEMING ◽  
RÉMI RABASA-LHORET ◽  
ANNE-SOPHIE BRAZEAU
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Management ◽  
Proof Of Concept ◽  
Concept Study ◽  
Preliminary Results

Long-term evaluation of adhesion formation and foreign body response to three new meshes

2014 ◽  
Vol 29 (8) ◽  
pp. 2251-2259 ◽  
Author(s):  
R. R. M. Vogels ◽  
K. W. Y. van Barneveld ◽  
J. W. A. M. Bosmans ◽  
G. Beets ◽  
M. J. J. Gijbels ◽  
...  
Keyword(s):  
Foreign Body ◽  
Adhesion Formation ◽  
Foreign Body Response ◽  
Term Evaluation ◽  
Body Response

Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomised proof-of-concept study

The Lancet ◽  
2001 ◽  
Vol 357 (9253) ◽  
pp. 331-335 ◽  
Author(s):  
Jay S Skyler ◽  
William T Cefalu ◽  
Ione A Kourides ◽  
William H Landschulz ◽  
Cecile C Balagtas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Human Insulin ◽  
Proof Of Concept ◽  
Concept Study

Long-term pericardial catheterization is associated with minimum foreign-body response

2007 ◽  
Vol 70 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Carlo R. Bartoli ◽  
Ichiro Akiyama ◽  
John J. Godleski ◽  
Richard L. Verrier
Keyword(s):  
Foreign Body ◽  
Foreign Body Response ◽  
Body Response
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