Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry

Diabetes ◽  
1998 ◽  
Vol 47 (2) ◽  
pp. 263-269 ◽  
Author(s):  
P. Hanifi Moghaddam ◽  
P. de Knijf ◽  
B. O. Roep ◽  
B. Van der Auwera ◽  
A. Naipal ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Genetic Structure ◽  
Major Histocompatibility ◽  
Diabetes Registry ◽  
Histocompatibility Complex

SIMPLE MODEL OF MATING PREFERENCE AND EXTINCTION RISK

2007 ◽  
Vol 18 (10) ◽  
pp. 1619-1625 ◽  
Author(s):  
ANDRZEJ PȨKALSKI
Keyword(s):  
Major Histocompatibility Complex ◽  
Genetic Structure ◽  
Simple Model ◽  
Extinction Risk ◽  
Mating Preference ◽  
Small Populations ◽  
Major Histocompatibility ◽  
Disassortative Mating ◽  
Histocompatibility Complex

We present a simple model of a population of individuals characterized by their genetic structure in the form of a double string of bits and the phenotype following from it. The population is living in an unchanging habitat preferring a certain type of phenotype (optimum). Individuals are unisex, however a pair is necessary for breeding. An individual rejects a mate if the latter's phenotype contains too many bad, i.e. different from the optimum, genes in the same places as the individual's. We show that such strategy, analogous to disassortative mating based on the major histocompatibility complex, avoiding inbreeding and incest, could be beneficial for the population and could reduce considerably the extinction risk, especially in small populations.

Genetic Structure of IDDM1: Two Separate Regions in the Major Histocompatibility Complex Contribute to Susceptibility or Protection

Diabetes ◽  
1998 ◽  
Vol 47 (2) ◽  
pp. 263-269 ◽  
Author(s):  
P. H. Moghaddam ◽  
P. de Knijf ◽  
B. O. Roep ◽  
B. Van der Auwera ◽  
A. Naipal ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Genetic Structure ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Relationship of Major Histocompatibility Complex Class II Genes to Inhibitor Antibody Formation in Hemophilia A

1990 ◽  
Vol 64 (04) ◽  
pp. 564-568 ◽  
Author(s):  
Lloyd E Lippert ◽  
Lyman Mc A Fisher ◽  
Lawrence B Schook
Keyword(s):  
Major Histocompatibility Complex ◽  
Factor Viii ◽  
Antibody Formation ◽  
Rflp Analysis ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Odds Ratios ◽  
Inhibitory Antibody ◽  
Histocompatibility Complex ◽  
Hla Dr

SummaryApproximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindII, PstI, PvuII and TaqI digested genomic DNA probed with DP beta, DQ alpha, DQ beta and DR beta class II MHC gene probes. The RFLP patterns for 16 non-inhibitor and 11 inhibitor hemophiliac patients were analyzed. These 24 enzyme:probe combinations generated 231 fragments. Fifteen (15) fragments associated with the inhibitor phenotype; odds ratios ranged from 5.1 to 45 and lower bounds of 95% confidence intervals were > 1.000 for all 15 fragments. Five (5) fragments associated with non-inhibitors, with odds ratios ranging from 6.4 to 51.7. This report establishes a MHC related genetic basis for the inhibitor phenotype. No statistically significant differences in the distribution of serologically defined HLA-DR phenotypes were observed between the inhibitor and non-inhibitor groups.

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