scholarly journals NADPH Oxidase-Derived Overproduction of Reactive Oxygen Species Impairs Postischemic Neovascularization in Mice with Type 1 Diabetes

2006 ◽  
Vol 169 (2) ◽  
pp. 719-728 ◽  
Author(s):  
Téni G Ebrahimian ◽  
Christophe Heymes ◽  
Dong You ◽  
Olivier Blanc-Brude ◽  
Barend Mees ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Type 1 Diabetes ◽  
Nadph Oxidase ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

2012 ◽  
Vol 302 (3) ◽  
pp. C597-C604 ◽  
Author(s):  
Rita M. Maalouf ◽  
Assaad A. Eid ◽  
Yves C. Gorin ◽  
Karen Block ◽  
Gladys Patricia Escobar ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Type 1 Diabetes ◽  
Molecular Markers ◽  
Nadph Oxidase ◽  
Diabetic Cardiomyopathy ◽  
Oxidase Activity ◽  
Diabetic Rats ◽  
Oxygen Species ◽  
Nadph Oxidase Activity

Oxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the NADPH oxidase Nox4 as a source of reactive oxygen species (ROS) involved in the development of diabetic cardiomyopathy. Phosphorothioated antisense (AS) or sense (S) oligonucleotides for Nox4 were administered for 2 wk to rats made diabetic by streptozotocin. NADPH oxidase activity, ROS generation, and the expression of Nox4, but Nox1 or Nox2, were increased in left ventricular tissue of the diabetic rats. Expression of molecular markers of hypertrophy and myofibrosis including fibronectin, collagen, α-smooth muscle actin, and β-myosin heavy chain were also increased. These parameters were attenuated by the administration of AS but not S Nox4. Moreover, the impairment of contractility observed in diabetic rats was prevented in AS- but not S-treated animals. Exposure of cultured cardiac myocytes to 25 mM glucose [high glucose (HG)] increased NADPH oxidase activity, the expression of Nox4, and molecular markers of cardiac injury. These effects of HG were prevented in cells infected with adenoviral vector containing a dominant negative form of Nox4. This study provides strong evidence that Nox4 is an important source of ROS in the left ventricle and that Nox4-derived ROS contribute to cardiomyopathy at early stages of type 1 diabetes.

Reactive Oxygen Species Damaged Hemoglobin Presents Unique Epitopes for Type 1 Diabetes Autoantibodies

2007 ◽  
Vol 2 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Zafar Rasheed ◽  
Rizwan Ahmad ◽  
Naila Rasheed ◽  
Trivendra Tripathi ◽  
Rashid Ali
Keyword(s):  
Reactive Oxygen Species ◽  
Type 1 Diabetes ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Diabetes Autoantibodies

scholarly journals Mitochondrial Reactive Oxygen Species and Type 1 Diabetes

2018 ◽  
Vol 29 (14) ◽  
pp. 1361-1372 ◽  
Author(s):  
Jing Chen ◽  
Scott E. Stimpson ◽  
Gabriel A. Fernandez-Bueno ◽  
Clayton E. Mathews
Keyword(s):  
Reactive Oxygen Species ◽  
Type 1 Diabetes ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species

scholarly journals The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

2013 ◽  
Vol 1281 (1) ◽  
pp. 16-35 ◽  
Author(s):  
Lindsey E. Padgett ◽  
Katarzyna A. Broniowska ◽  
Polly A. Hansen ◽  
John A. Corbett ◽  
Hubert M. Tse
Keyword(s):  
Reactive Oxygen Species ◽  
Type 1 Diabetes ◽  
Proinflammatory Cytokines ◽  
Reactive Oxygen ◽  
Oxygen Species
Sign in / Sign up

Export Citation Format

Share Document