Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme

2018 ◽  
Vol 62 (2) ◽  
Author(s):  
Stefanie Brehmer ◽  
Christian V. Guthier ◽  
Sven Clausen ◽  
Frank Schneider ◽  
Dirk-Michael Schulte ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Stereotactic Biopsy ◽  
Interstitial Irradiation

Changes in Proliferating Cell Nuclear Antigen Expression in Glioblastoma Multiforme Cells along a Stereotactic Biopsy Trajectory

Neurosurgery ◽  
1994 ◽  
Vol 35 (6) ◽  
pp. 1036???1045 ◽  
Author(s):  
Stephen J. Dalrymple ◽  
Joseph E. Parisi ◽  
Patrick C. Roche ◽  
Steven C. Ziesmer ◽  
Bernd W. Scheithauer ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Proliferating Cell Nuclear Antigen ◽  
Stereotactic Biopsy ◽  
Antigen Expression ◽  
Nuclear Antigen ◽  
Proliferating Cell

Changes in Proliferating Cell Nuclear Antigen Expression in Glioblastoma Multiforme Cells along a Stereotactic Biopsy Trajectory

Neurosurgery ◽  
1994 ◽  
Vol 35 (6) ◽  
pp. 1036-1045 ◽  
Author(s):  
Stephen J. Dalrymple ◽  
Joseph E. Parisi ◽  
Patrick C. Roche ◽  
Steven C. Ziesmer ◽  
Bernd W. Scheithauer ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Proliferating Cell Nuclear Antigen ◽  
Stereotactic Biopsy ◽  
Antigen Expression ◽  
Nuclear Antigen ◽  
Proliferating Cell

Stereotactic Biopsy in the Diagnosis of Brain Masses: Comparison of Results of Biopsy and Resected Surgical Specimen

Neurosurgery ◽  
1989 ◽  
Vol 24 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Parakrama T. Chandrasoma ◽  
Maurice M. Smith ◽  
Michael L. J. Apuzzo
Keyword(s):  
Glioblastoma Multiforme ◽  
Clinical Management ◽  
Stereotactic Biopsy ◽  
Granulomatous Inflammation ◽  
Brain Biopsy ◽  
Diagnostic Error ◽  
Stereotactic Brain Biopsy ◽  
Biopsy Material ◽  
Surgical Specimen ◽  
Oligodendroglial Component

Abstract We report the pathological accuracy of image-directed stereotactic brain biopsy in 30 patients who had mass lesions of the brain and subsequently underwent resection of the mass. The histological diagnosis at stereotactic biopsy was appropriate for direction of clinical management in 28 of 30 patients. Correlation between the stereotactic and resection diagnoses was exact in 19 of 30 cases. These included 11 of 12 nonastrocytic neoplasms and 8 of 13 astrocytic neoplasms. Correlation was imperfect in 9 of 30 cases, but not to the extent of having significant clinical impact. These included 2 cases of anaplastic astrocytoma that were upgraded to glioblastoma multiforme, 2 cases of astrocytoma that had a significant oligodendroglial component, and 5 non-neoplastic lesions that were reported on biopsy as showing nonspecific reactive changes. In 2 of 30 patients, the stereotactic biopsy was not accurate. This included one patient who had glioblastoma multiforme whose stereotactic biopsy showed only necrotic tissue. Serious diagnostic error that resulted in clinical mismanagement occurred in one patient who had a pineal germinoma that had large areas of granulomatous inflammation at which the stereotactic biopsy was directed. This study provides evidence that, with careful target placement, stereotactic biopsy can provide biopsy material that represents the entire lesion with an accuracy that is sufficient for clinical management.

scholarly journals Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase in Human Cerebral Cortex and Glioblastoma Multiforme

1996 ◽  
Vol 23 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Sumeer Lal ◽  
Rajala V.S. Raju ◽  
Robert J.B. Macaulay ◽  
Rajendra K. Sharma
Keyword(s):  
Cerebral Cortex ◽  
Catalytic Activity ◽  
Glioblastoma Multiforme ◽  
Brain Tumors ◽  
Polyclonal Antibody ◽  
Spectrophotometric Method ◽  
Cyclic Nucleotide ◽  
Stereotactic Biopsy ◽  
Bovine Brain ◽  
Cerebral Tissue

AbstractBackground: Calmodulin-dependent cyclic nucleotide phosphodiesterase (CaMPDE) has been extensively studied and characterized in normal mammalian tissues; however very little is known about this enzyme in human brain tumors. It has been established that high levels of this enzyme exist in non-central nervous system tumors, PDE inhibitors or cAMP analogues have been used to treat them. This study has examined the levels of CaMPDE in glioblastoma multiforme from six patients and has compared these to the levels of CaMPDE in four patients with normal cerebral tissue. In addition, an enzyme immune assay method (EIA) was developed in this study for the detection of CaMPDE in human cerebral tissue. This method is proposed to be used as an adjunct to the spectrophotometric method presently utilized. This would be beneficial in cases where small tissue samples, for example in stereotactic biopsy, are available. Methods: The CaMPDE activity and corresponding levels of expression in cerebral tissue from temporal lobectomies and both surgical extraction or stereotactic biopsy in patients with primary tumors were determined by spectophotometric and EIA, respectively. The EIA was developed from the production of a polyclonal antibody against bovine brain 60 kDa CaMPDE isozyme. Cross reactivity of the antibody with human was confirmed using transblot and immunohistochemistry. Results: Utilising the EIA, there was found to be significant reduction in both catalytic activity (p < 0.001) and in quantitative protein expression (p < 0.001) in glioblastoma multiforme from patients when compared to normal cerebral cortex. Immunoblotting experiments and immunohistochemistry demonstrated that CaMPDE in glioblastoma multiforme failed to react with a polyclonal antibody raised against bovine brain 60 kDa CaMPDE isozyme, whereas the enzyme from normal tissue reacted with antibody. Conclusions: Contrary to other studies on non-CNS tumors, the catalytic activity and the protein expression of CaMPDE is reduced in glioblastoma multiforme. The EIA method is a more sensitive in detecting CaMPDE than in the spectrophotometric method, especially when a small amount of tissue is available. Immunohistochemistry and the EIA may be useful in the future to use as markers for other types of brain tumors and not for glioblastoma multiforme as demonstrated.

Metastasis Along the Stereotactic Biopsy Trajectory in Glioblastoma Multiforme

1999 ◽  
Vol 141 (9) ◽  
pp. 1011-1012 ◽  
Author(s):  
A. Pierallini ◽  
F. Caramia ◽  
M. C. Piattella ◽  
P. Pantano ◽  
A. Santoro ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Stereotactic Biopsy

scholarly journals De novo cerebellar medulloblastoma in a 26-year recurrence-free case of temporal glioblastoma multiforme

2003 ◽  
Vol 14 (4) ◽  
pp. 1-8 ◽  
Author(s):  
Javier Fandino ◽  
Adrian M. Siegel ◽  
R. Hubert Laeng ◽  
M. Gazi Yaºargil
Keyword(s):  
Glioblastoma Multiforme ◽  
Stereotactic Biopsy ◽  
De Novo ◽  
Radiological Findings ◽  
Left Shift ◽  
Free Case ◽  
Cerebellar Medulloblastoma ◽  
Vascular Structures ◽  
The Right

The authors describe a patient who survived 26 years after resection of a right temporal glioblastoma multiforme (GBM) without signs of tumor recurrence. Preoperative emergency angiography demonstrated a hypovascular mass localized in the right temporal lobe with right-to-left shift of the vascular structures. At surgery, the tumor had cystic and solid components localized in the lateral occipitotemporal gyrus, reaching the posterolateral wall of the inferior horn of the right lateral ventricle and extending to the trigone and posterior horn. The initial pathological diagnosis of a GBM was reviewed and confirmed throughout the follow-up period. Twenty-six years after surgery and subsequent radiosurgery, the patient underwent resection of a medulloblastoma localized in the right cerebellum as well as stereotactic biopsy sampling of tissue at the original GBM site. Neither radiological nor histological evidence of recurrence of the GBM could be documented. The intraoperative, histological, and radiological findings are described.

Glioblastoma Multiforme with Atypical Appearance

2019 ◽  
Vol 70 (7) ◽  
pp. 2694-2698
Author(s):  
Anca Alexandra Grigorie ◽  
Ramona Adriana Schenker ◽  
Michael Schenker
Keyword(s):  
Differential Diagnosis ◽  
Glioblastoma Multiforme ◽  
Histological Examination ◽  
Stereotactic Biopsy ◽  
Motor Deficit ◽  
Attention Disorders ◽  
The Past ◽  
Cerebral Mri ◽  
The Right ◽  
Ct And Mri

We present the case of a 68-year-old patient who is hospitalized in our clinic for cognitive and attention disorders, progressively progressing over the past three months. The neurological examination revealed, besides cognitive decline, a motor deficit in the right limbs, and mild swallowing disorders for liquids. Although both CT and MRI were performed, the images obtained from the investigations were inconclusive, raising differential diagnosis problems. The patient was subjected to additional investigations, but the diagnosis of certainty was established by performing sterotactic biopsy and histological examination. Although cerebral MRI is the investigation of choice in the diagnosis of glioblastoma, in our patient�s case, the diagnosis of certainty was determined by stereotactic biopsy and subsequent histological examination.

Analysis and applicability of different in vitro models of Glioblastoma multiforme

2014 ◽  
Vol 226 (06) ◽  
Author(s):  
D William ◽  
M Linnebacher ◽  
CF Classen
Keyword(s):  
Glioblastoma Multiforme ◽  
In Vitro Models
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