Gluten-sensitive enteropathy of the Irish Setter and similarities with human celiac disease

2020 ◽  
Vol 66 (2) ◽  
Author(s):  
Federico Biagi ◽  
Stiliano Maimaris ◽  
Carla G. Vecchiato ◽  
Martina Costetti ◽  
Giacomo Biagi
Keyword(s):  
Celiac Disease ◽  
Gluten Sensitive Enteropathy

scholarly journals The Broad Spectrum of Celiac Disease and Gluten Sensitive Enteropathy

2016 ◽  
Vol 89 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Oana Mocan ◽  
Dan L. Dumitrașcu
Keyword(s):  
Celiac Disease ◽  
Viral Infections ◽  
Villous Atrophy ◽  
Intraepithelial Lymphocytes ◽  
Intestinal Biopsy ◽  
Gluten Free ◽  
Serological Tests ◽  
Genetic Transmission ◽  
Intestinal Involvement ◽  
Gluten Sensitive Enteropathy

The celiac disease is an immune chronic condition with genetic transmission, caused by the intolerance to gluten. Gluten is a protein from cereals containing the following soluble proteins: gliadine, which is the most toxic, and the prolamins. The average prevalence is about 1% in USA and Europe, but high in Africa: 5.6% in West Sahara. In the pathogenesis several factors are involved: gluten as external trigger, genetic predisposition (HLA, MYO9B), viral infections, abnormal immune reaction to gluten. Severity is correlated with the number of intraepithelial lymphocytes, cryptic hyperplasia and villous atrophy, as well as with the length of intestinal involvement. The severity is assessed according to the Marsh–Oberhuber staging. Diagnostic criteria are: positive serological tests, intestinal biopsy, the reversal after gluten free diet (GFD). Beside refractory forms, new conditions have been described, like the non celiac gluten intolerance. In a time when more and more people adhere to GFD for nonscientific reasons, practitioners should be updated with the progress in celiac disease knowledge.       

Gluten-Sensitive Enteropathy (Celiac Disease): Controversies in Diagnosis and Classification

2010 ◽  
Vol 134 (6) ◽  
pp. 826-836 ◽  
Author(s):  
Arzu Ensari
Keyword(s):  
Celiac Disease ◽  
Disease Diagnosis ◽  
Classification Systems ◽  
Intestinal Biopsy ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Pathologic Features ◽  
Gluten Sensitive Enteropathy ◽  
Intraepithelial Lymphocytosis

Abstract Context.—Celiac disease, or gluten-sensitive enteropathy, is a chronic inflammatory disorder of the small intestine characterized by malabsorption after ingestion of gluten in individuals with a certain genetic background. Clinical presentation can vary from full-blown malabsorption to subtle and atypical symptoms. Diagnosis currently relies on clinicopathologic studies including mucosal biopsy, serologic tests, and the effects of a diet free of gluten on the symptoms. Mucosal pathologic features are also variable, ranging from mild abnormalities, including intraepithelial lymphocytosis, to completely flat mucosa. Since patients with minimal histologic lesion of intraepithelial lymphocytosis often present with normal serologic findings, biopsy diagnosis becomes more important for identifying such individuals. Classification of mucosal pathology in gluten-sensitive enteropathy has been a subject of controversy among pathologists and needs to be revised according to the current understanding of the disease. Objectives.—To highlight the variations in clinical and pathologic presentation of gluten-sensitive enteropathy, to emphasize the importance of small-intestinal biopsy evaluation in the diagnosis, and to propose a new classification of mucosal pathology in gluten-sensitive enteropathy, in an effort to overcome the problems related to the classification systems currently available. Data Sources.—A review of the literature on clinicopathologic features and the morphologic spectrum of gluten-sensitive enteropathy is presented. Conclusions.—Considering that there are many entities in the differential diagnosis of gluten-sensitive enteropathy, because of the varied clinicopathologic spectrum of the disease, diagnosis depends on good clinicopathologic communication. The classification that is presented in this review is a simple and practical approach to improve clinicopathologic correlation in gluten-sensitive enteropathy.

scholarly journals Testing for Antireticulin Antibodies in Patients with Celiac Disease Is Obsolete: a Review of Recommendations for Serologic Screening and the Literature

2013 ◽  
Vol 20 (4) ◽  
pp. 447-451 ◽  
Author(s):  
Sarada L. Nandiwada ◽  
Anne E. Tebo
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Clinical Manifestations ◽  
Autoimmune Disorder ◽  
Diagnostic Use ◽  
Gliadin Peptide ◽  
Gluten Sensitive Enteropathy ◽  
Serologic Screening ◽  
Related Proteins ◽  
Hla Dq2

ABSTRACTCeliac disease (CD) is an autoimmune disorder that occurs in genetically susceptible individuals of all ages and is triggered by immune response to gluten and related proteins. The disease is characterized by the presence of HLA-DQ2 and/or -DQ8 haplotypes, diverse clinical manifestations, gluten-sensitive enteropathy, and production of several autoantibodies of which endomysial, tissue transglutaminase, and deamidated gliadin peptide antibodies are considered specific. Although antireticulin antibodies (ARA) have historically been used in the evaluation of CD, these assays lack optimal sensitivities and specificities for routine diagnostic use. This minireview highlights the advances in CD-specific serologic testing and the rationale for eliminating ARA from CD evaluation consistent with recommendations for diagnosis.

scholarly journals GGLUTEN-SENSITIVE ENTEROPATHY - NEW VIEW ON PROBLEM

2021 ◽  
Author(s):  
Tsitsi Parulava ◽  
David Pruidze ◽  
Maia Chkhaidze ◽  
Tamar Gotua ◽  
Irma Mandjavidze
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Age Groups ◽  
Failure To Thrive ◽  
Elimination Diet ◽  
Epidemiologic Studies ◽  
Intestinal Biopsy ◽  
Common Symptom ◽  
Small Intestinal Biopsy ◽  
Gluten Sensitive Enteropathy

Gluten sensitive enteropathy-celiac disease is an immune-mediated disorder caused by permanent sensitivity to gluten in genetically susceptible individuals. Epidemiologic studies of last years suggest that it is common and may occur in 0,5-1% of the general population. The bowel inflammatory and immunologic response results in atrophy and damage in the small bowel and secondary malabsorbtion. The mode of presentation can be quite variable. Celiac disease is generally defined as chronic diarrea and failure to thrive in infants and toddlers, diarrhea is still the most common symptom, but disease may occure in different age groups and with exstraintestinal, sometimes monosymptomic clinic. Clinical forms of celiac disease are: classic, atypical, silent, latent and potential. Definitive diagnose of Celiac disease requires serrologic screening, small intestinal biopsy and effectiveness of elimination diet. Anti-tissue transglutaminase antybody test (TTG IgA and TTG IgG) is highly sensitive, specific and less expensive, thus is recommended for general practice. None of serologic tests are 100% reliable. Definitive diagnosis requires characteristic histologic changes in intestine mucus. Tissue for investigation may be taken from duodenum during gastro endoscopy. Diagnosing only by results of gluten-free diet is not correct. The only treatment for celiac disease is lifelong exclusion of gluten. Early diagnosis and strict dietary restrictions appear to be the only possibility of prevention risk for failure to thrive, delay of sexual maturity, autoimmune disorders, adenocarcinoma of gastrointestinal tract and lymphoma.

scholarly journals Spontaneous jejunoileal perforation as a manifestation of celiac disease—a rare entity: a case report

2020 ◽  
Vol 2020 (7) ◽  
Author(s):  
Alex Paul Guachilema Ribadeneira ◽  
Naysi Cristina Zambrano Martinez ◽  
Silvana Alexandra Valencia Valverde ◽  
Raúl Ernesto Villacis Peñaherrera ◽  
Fabian Medardo Romero Chacón ◽  
...  
Keyword(s):  
Small Intestine ◽  
Celiac Disease ◽  
Clinical Manifestations ◽  
Human Leukocyte ◽  
Rare Condition ◽  
Autoimmune Response ◽  
Classical Type ◽  
High Morbidity ◽  
Gluten Sensitive Enteropathy ◽  
Hla Dq2

Abstract Celiac disease or gluten-sensitive enteropathy is characterized by an autoimmune response in the small intestine triggered by the ingestion of gluten in the diet. It has a prevalence of 0.62% worldwide with considerable variation in incidence among countries. The clinical manifestations of celiac disease differ according to type: the classical type presents with intestinal symptoms, the non-classical type with intestinal or extraintestinal symptoms and the silent type is asymptomatic. Human leukocyte antigens (HLA)-DQ2 (DQA1_05/DQB1_02) are expressed in >90% of patients with celiac disease, and the presence of HLA-DQ2 or HLA-DQ8 (DQA1_ 0301/DQB1_0302) is necessary for its development. One complication of this disease is ulcerative jejunoileitis, a rare condition characterized by chronic idiopathic ulceration affecting the small intestine that can cause intestinal perforation resulting in high morbidity.

Sign in / Sign up

Export Citation Format

Share Document