scholarly journals Preparation &Characterization of Bosentan Loaded Ethyl cellulose Nanoparticles by Solvent Evaporation Technique

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Abbaraju Krishnasailaja
Keyword(s):  
Ethyl Cellulose ◽  
Solvent Evaporation ◽  
Cellulose Nanoparticles ◽  
Evaporation Technique

scholarly journals Effect of Cellulosic and Polymethacrylic Polymers on Drug Content, Particle Morphology, and Carbamazepine Release Profiles from Sustained Release Ethyl Cellulose Microspheres

1970 ◽  
Vol 9 (2) ◽  
pp. 75-82 ◽  
Author(s):  
Sams Mohammad Anowar Sadat ◽  
Md Saiful Islam ◽  
Sheikh Tasnim Jahan ◽  
Jakir Ahmed Chowdhury ◽  
Reza-ul Jalil
Keyword(s):  
Sustained Release ◽  
Release Rate ◽  
Ethyl Cellulose ◽  
Sodium Dodecyl ◽  
In Vitro Release ◽  
Particle Diameter ◽  
Solvent Evaporation ◽  
Drug Content ◽  
Key Words Carbamazepine ◽  
Evaporation Technique

Emulsion-solvent evaporation technique was used to prepare Carbamazepine (CBZ) loaded Ethyl Cellulose (EC) microspheres. Cellulosic polymers (HPMC 4.5 cps, 15 cps) and polymethacrylic polymers (Eudragit E100, Eudragit RL PO, Eudragit RS PO) were added with EC at 10% (w/w) of EC. The effect of these polymers on drug content, particle size, and CBZ release rate were evaluated. The CBZ encapsulation efficiency and the drug content varied from 85% to 95% and from 42% to 45% (w/w), respectively. The mean particle diameter varied from 460 to 730 μm. In vitro release study for 8 hours was conducted in 1% (w/v) sodium dodecyl sulfate solution. All the polymers reduced the release of CBZ and a statistically significant variation in release rate was observed from polymer to polymer. Key words: Carbamazepine; Ethyl Cellulose; Sustained release microspheres; Emulsion-Solvent Evaporation Technique. DOI: http://dx.doi.org/10.3329/dujps.v9i2.7883 Dhaka Univ. J. Pharm. Sci. 9(2): 75-82, 2010 (December)  

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