Short Review on Novel Dosage Form

Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.

Formulation development and in vitro Evaluation of sustained release matrix tablets of Cefpodoxime proxetil

The present focus is on the development of sustained release formulations due to its inherent boons. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance, reduction in fluctuation and increased safety margin of potent drug. The present study was aimed to prepare a sustained drug delivery system to design a controlled release oral dosage form of Cefpodoxime proxetil. The sustained release matrix tablets of Cefpodoxime proxetil were prepared by wet granulation and evaluated for different parameters such as weight variation, drug content, thickness, hardness, friability and In vitro release studies. The in vitro dissolution study was carried out for 12 hours using USP (Type- II) paddle apparatus in hydrochloride (0.1N) as dissolution media for first 2 hours and phosphate buffer (pH 6.8) for next 10 hours. Based on the in vitro dissolution data, formulation F8 was selected as the best formulation from Cefpodoxime proxetil formulations (F1 – F9) as the drug release was retarded up to 12 hours with 96.29 % and followed zero order release kinetics & drug release mechanism was diffusion.

Nanotechnology: Overview and its application

The study of different microscopic or tiny shaped and sized particles is what nanotechnology is all about. These nano-structured compounds have a wide range of strong actions in a variety of disciplines. These are readily carried due to their small size and form. Because of its small size, it may be used in a variety of ways. Nanotechnology improves a variety of businesses, including the pharmaceutical industry, the food industry, environmental protection, and a variety of others. The purpose of this article is to provide an overview of nanotechnology and its applications in different industries and areas.

Formulation and Evaluation of Orodispersible Tablet of poorly water Soluble Drug ‘Fenofibrate’ by Using Solubility Enhancement Technique

In the recent years scientific and technological advancements have been made in the research and development of oral drug delivery systems. The aim of this study was to formulate and evaluate of orodispersible tablets by direct compression for fenofibrate by using super fast disintegrating agents like croscarmellose sodium. The use of super disintegrant and excipient for preparation of fast disintegrating is highly effective and commercially feasible. In the present investigation poorly water soluble drug is one of the most important parameters of oral formulations sucessfully developed fenofibrate was using solvent evaporation method drug: PEG 6000 in (1:5 w/w). The formulation F7 was the optimized formula that showed satisfactory results with various physicochemical evaluation parameters like thickness, hardness, weight variation, friability, drug content, % drug release almost 79.98% within 15 min. and it was follow the maximum higuchi release kinetics that regression coefficient values ‘r2’= 0.995.

Bioelectric Medicine: Magicall Tools for Treatment of Many Diseases

Bioelectronic medicine is a relatively new area that focuses on developing methods for treating diseases that do not need medications. Bioelectronic medicine treatments are now possible thanks to a small embedded system that produces and delivers frequent digital doses to nerve bundles, resulting in a disease-fighting effect that can last hours or days and is based on mechanisms similar to drug therapies. Although this may sound like science fiction, electronic brain and nerve stimulators are now presence applicable to treat so many of ailments, including epilepsy, Parkinson's disease, and bladder control. Progress in treating such disorders has opened up possibilities for boosting memory, improving eyesight, strengthening a shaky gait, and even improving a golfer's swing. Those self-improvement dreams may be a long way off, but bioelectronic medicine is gaining traction as a new way to treat difficult diseases. What distinguishes bioelectronic medicine is its biological effect on the body, which goes beyond symptom management to treat the underlying condition by using the body's own mechanisms. With promising early results in many trials and further trials ongoing, bioelectronic therapies are likely to be accepted for clinical use within the next few years. To make this advancement possible, forward-thinking scientists, engineers, doctors, and innovators with specialised talents combined old and new discoveries in ways no one had before.

Formulation and Evaluation of Polyherbal Antiaging Cream

Moringa oleifera family Moringaceae and Ocimum sanctum family Labiatae has been reported to possess antioxidant, antimicrobial, antiinflammatory, antibacterial and antifungal properties. Moringa oleifera and Ocimum sanctum extracts have been used to treat antimicrobial infections. The aim of this present study is to formulate and evaluate of polyherbal anti-aging cream by combining the extract of Moringa oleifera with Ocimum sanctum to achieve multipurpose skin effects such as anti-aging, fairness, softening and antiseptic effects.The polyherbal anti-aging cream formulations comprising of hydroalcoholic extract of Moringa oleifera and Ocimum sanctum, carbapol 940, xanthan gum, stearic acid, glycerol monostearate and cetyl alcohol were prepared and evaluated for physicochemical parameters and the results showed the production of stable polyherbal anti-aging cream. The formulated polyherbal anti-aging cream (O/W) was subjected to characterize like visual inspection, pH, viscosity, good spreadability, good consistency, homogeneity, no evidence of phase separation and ease to washable from skin. Formulation (F4) exhibited fulfilled the objectives of the current research and % drug release is 98.78 and exhibit good anti-microbial activity.

A Short Review on Nasal Drug Delivery System

Nasal drug delivery has received a great deal of attention as convenient, reliable and promising methods for the systemic administration of drug. It is especially for those molecules which are ineffective oraly and only effective if administration by injection. The nasal route of drug delivery has advantage over the other alternative system of drug administration. The present review is an attempt to provide some information concerning nasal drug delivery system such as limitation, advantage, mechanism drug absorption, anatomy and Physiology Nasal, factor affecting of nasal drug delivery, drug distribution and deposition, Challenges and oppurtunities for Nasal Delivery Systems1. These drug delivery system have the ability to control the rate of drug clearance from the nasal cavity as well as protect the drug from enzymatic degradation in nasal secretions2..

Chemical Composition of Oroxylum indicum: A Review

Root bark of sonapatha is an astringent, tonic, anti-diarrhoeal, diuretic, anodyne, and is used to cure dropsy. It is an ingredient of ‘dashamoolarishta’ of Ayurvedic medicine. Stem bark is anti-rheumatic. An infusion of bark powder is diaphoretic. Tender fruits have spas- molytic, carminative, and stomachic properties, while seeds are purgative.it is a medium-sized, soft-wooded tree attaining a height of 10–16 m. Stem bark is dull brown in colour; leaves are broad, 60–120 cm in length and pinnately compound. Leaflets are ovate, wavy, and acuminate. Leaf fall occurs during winter season (January) each year. The tree is recognized by ternately bipinnate leaves. The root bark contains chrysin, baicalein, dehydrobaicalein, and orozylin. Stem bark possesses flavonoids such as oroxylin, baicalein, scutelarin and 7-rutinoside, chrysin, and p-coumaric acid. Heartwood yields β-sitosterol and isoflavone-prunetin. Root bark of sonapatha is an astringent, tonic, anti-diarrhoeal, diuretic, anodyne, and is used to cure dropsy. It is an ingredient of ‘dashamoolarishta’ of Ayurvedic medicine. Stem bark is anti-rheumatic. An infusion of bark powder is diaphoretic. Tender fruits have spas- molytic, carminative, and stomachic properties, while seeds are purgative. It is a medium-sized, soft-wooded tree attaining a height of 10–16 m. Stem bark is dull brown in colour; leaves are broad, 60–120 cm in length and pinnately compound. Leaflets are ovate, wavy, and acuminate. Leaf fall occurs during winter season (January) each year. The tree is recognized by ternately bipinnate leaves. The root bark contains chrysin, baicalein, dehydrobaicalein, and orozylin. Stem bark possesses flavonoids such as oroxylin, baicalein, scutelarin.

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Anti-Diabetic Drug using 23 Factorial Design

The aim of the present study involved the formulation and evaluation of mucoadhesive buccal tablets of anti-diabetic drug gliclazide, Mucoadhesive buccal tablets of Gliclazide are prepared by direct compression method In this present investigational research work the mucoadhesive buccal tablets of gliclazide is prepared separately employing 23 randomized full factorial design by using xanthan gum, carbopol-934, HPMC-E15LV, In this experimental model, target is to determine how the t90% of drug release and mucoadhesive characters can be affected by adjusting three parameters, concentration of polymers xanthan gum, HPMC-E15LV, carbopol-934, of the mucoadhesive buccal tablets. 2 3 full factorial studies were designed to determine the interaction of three independent variables at two levels (low and high level concentration) The tablets were tested for weight variation, hardness, surface pH, drug content uniformity, swelling index, mucoadhesion strength and in-vitro drug release study, Ex- vivo mucoadhesion time. From the drug release studies it was found that formulation H4 containing has good drug release when compared to other formulations.

Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel

The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 and F-15 were selected for further studies. Though F-16, F-17, F-18, F-19 and F-20 formulations are also stable, but rejected due to high concentration of surfactant can cause skin irritation, skin burning and/or other complications. Characterization of selected voriconazole microemulsion formulations were evaluated under various parameters like Droplet size, Zeta potential, Poly Dispersity Index (PDI) and (%) Drug content all results showed.