Preparation and characterization of co-amorphous Ritonavir–Indomethacin systems by solvent evaporation technique: Improved dissolution behavior and physical stability without evidence of intermolecular interactions

2014 ◽  
Vol 62 ◽  
pp. 57-64 ◽  
Author(s):  
Swapnil J. Dengale ◽  
Om Prakash Ranjan ◽  
Syed Sajjad Hussen ◽  
B.S.M. Krishna ◽  
Prashant B. Musmade ◽  
...  
Keyword(s):  
Intermolecular Interactions ◽  
Physical Stability ◽  
Solvent Evaporation ◽  
Dissolution Behavior ◽  
Evaporation Technique

Characterization, Physical Stability, and Dissolution Behavior of Naringenin / Mannitol Solid Dispersions Prepared by Solvent Evaporation Method with Three Drying Methods

2011 ◽  
Vol 236-238 ◽  
pp. 2264-2272
Author(s):  
Guang Fa Wang ◽  
Chun Lan Dai ◽  
Zheng Gen Liao ◽  
Guo Wei Zhao ◽  
Xin Li Liang ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersions ◽  
Physical Stability ◽  
Solvent Evaporation ◽  
Vacuum Drying ◽  
Dissolution Behavior ◽  
Drying Methods ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Ft Ir

Solid dispersions (SD) were prepared with naringenin and mannitol by the solvent evaporation method with three drying methods (vacuum drying, VD; microwave-vacuum drying, MVD; and spray drying, SPD). The SD was characterized by Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (PXRD), Scanning Electronic Microscope (SEM), and Fourier Transform Infrared Spectroscopy (FT-IR).In vitrodissolution of naringenin and physical stability was investigated, and the energy consumption of different processing methods was measured. The results showed that the vitro dissolution rate and extent of naringenin was significantly improved by SD prepared with different drying methods compared to that of the pure drug and physical mixture (PM), and the dissolution rate of SD-SPD and SD-MVD was much higher than the SD-VD. The results of FT-IR showed that naringenin is possibly interacted with mannitol via intermolecular hydrogen bond; The PXRD showed that the crystallinity of the SD prepared with three drying methods was reduced sharply as compared with pure naringenin and PM. There results showed that the physical state of SD-MVD was more stable than SD-SPD and SD-VD that stored in the 40 °C/75% RH chamber in three month. Compared with other drying methods, the MVD method can save time and energy. These results suggest that MVD is feasible to replace the traditional time-consuming and low efficiency drying procedure for preparation of solid dispersions.

Crystal growth and characterization of CuI single crystals by solvent evaporation technique

2010 ◽  
Vol 45 (5) ◽  
pp. 636-639 ◽  
Author(s):  
Mu Gu ◽  
Pan Gao ◽  
Xiao-Lin Liu ◽  
Shi-Ming Huang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Single Crystals ◽  
Solvent Evaporation ◽  
Evaporation Technique
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