In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs

2000 ◽  
Vol 61 (7) ◽  
pp. 802-810 ◽  
Author(s):  
Patricia Kay-Mugford ◽  
Sally J. Benn ◽  
Jonathan LaMarre ◽  
Peter Conlon
Keyword(s):  
Cyclooxygenase Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
In Vitro Effects

In Vitro Effects of Selective and Non-Selective Nonsteroidal Anti-Inflammatory Drugs on the???Frequency of Sister Chromatid Exchanges

Drugs in R&D ◽  
2004 ◽  
Vol 5 (6) ◽  
pp. 327-330 ◽  
Author(s):  
S??kr?? ??zt??rk ◽  
Banu G K??seoglu ◽  
H??lya Ko??ak ◽  
S??kr?? Palanduz ◽  
Kivan?? ??efle ◽  
...  
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchanges ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
In Vitro Effects ◽  
Chromatid Exchanges

Meseclazone, 5-Chlorosalicylic Acid and Acetylsalicvlic Acid

1978 ◽  
Vol 40 (01) ◽  
pp. 024-036 ◽  
Author(s):  
William Diamantis ◽  
William C Kohlhepp ◽  
Barbara Haertlein ◽  
John Melton ◽  
R Duane Sofia
Keyword(s):  
Platelet Aggregation ◽  
Oral Administration ◽  
Secondary Phase ◽  
Ex Vitro ◽  
Antipyretic Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
In Vitro Effects ◽  
Induced Aggregation

SummaryMeseclazone and its major metabolite, 5-chlorosalicylic acid (5-CSA) have been shown to possess anti-inflammatory, analgesic and antipyretic activity. The comparative effects of these compounds on platelet aggregation were evaluated in vitro and ex vitro with acetylsalicylic acid (ASA). in vitro, meseclazone and ASA exhibited almost identical inhibitory potency of secondary phase ADP aggregation while 5-CSA was less effective. Moreover, collagen aggregation was inhibited by all three agents: ASA > meseclazone > 5- CSA. Thrombin-induced aggregation was inhibited to approximately the same extent by 5- CSA and ASA while meseclazone was inactive. The in vitro effects on the release-inducing aggregants were confirmed by ex vitro experiments in rats. These demonstrated that ASA and meseclazone inhibited collagen-induced aggregation 1 and 4 hr after oral administration although ASA was three to four times more active. ASA, but not meseclazone, was still effective 24 hr after administration. Bleeding times in rats 1 and 4 hr following oral administration of meseclazone and ASA were not altered. It is concluded that meseclazone and/or 5-CSA inhibit in vitro and ex vitro platelet aggregation initiated by the release reaction similar to ASA and other non-steroidal anti-inflammatory drugs.

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