Evaluation of the analgesic effect of intracameral lidocaine hydrochloride injection on intraoperative and postoperative pain in healthy dogs undergoing phacoemulsification

Abstract Background Postoperative pain is common in patients hospitalized in surgical departments, yet it is currently not sufficiently controlled by analgesics. Acupuncture, a complementary medical practice, has been evaluated for its benefits in postoperative pain with heterogeneous results. We tested the feasibility of a controlled study comparing the postoperative analgesic effect of acupuncture together with standard-of-care to standard-of-care only. Methods In this pilot non-randomized controlled study conducted at a tertiary medical center in Israel, patients received either acupuncture with standard-of-care pain treatment (acupuncture group) or standard-of-care treatment only (control group) following surgery. Visual Analogue Scale (VAS) ratings for pain level at rest and in motion were evaluated both at recruitment and two hours after treatment. Acupuncture-related side effects were reported as well. Results We recruited 425 patients; 336 were assigned to the acupuncture group and 89 to the control group. The acupuncture group exhibited a decrease of at least 40% in average level of pain both at rest (1.8±2.4, p<0.0001) and in motion (2.1±2.8, p<0.0001) following acupuncture, whereas the control group exhibited no significant decrease (p=0.92 at rest, p=0.98 in motion). Acupuncture's analgesic effect was even more prominent in reducing moderate to severe pain at baseline (VAS ≥4), with a decrease of 49% and 45% of pain level at rest and in motion respectively (p<0.001), compared with no significant amelioration in the control group (p=0.20 at rest, p=0.12 in motion). No major side effects were reported. Conclusion Integrating acupuncture with standard care may improve pain control in the postoperative setting.

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Analgesic effect of picenadol, codeine, and placebo in patients with postoperative pain

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.1988.92 ◽

1988 ◽

Vol 43 (6) ◽

pp. 663-667 ◽

Cited By ~ 11

Author(s):

Rocco L Brunelle ◽

Richard E George ◽

Abraham Sunshine ◽

William D Hammonds

Keyword(s):

Postoperative Pain ◽

Analgesic Effect

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Comparison of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament with posterior quadratus lumborum block for perioperative analgesia in laparoscopic nephrectomy: a protocol for a randomised, prospective, parallel group, non-inferior trial

BMJ Open ◽

10.1136/bmjopen-2020-048490 ◽

2021 ◽

Vol 11 (8) ◽

pp. e048490

Author(s):

Xiao Huang ◽

Yuan Sun ◽

Rong Shi ◽

Danxu Ma ◽

Anshi Wu ◽

...

Keyword(s):

Postoperative Pain ◽

Analgesic Effect ◽

Laparoscopic Nephrectomy ◽

Patient Satisfaction Score ◽

Perioperative Analgesia ◽

Quadratus Lumborum Block ◽

Parallel Group ◽

Quadratus Lumborum ◽

First Onset ◽

Arcuate Ligament

ObjectiveAnterior quadratus lumborum block at the lateral supra-arcuate ligament (QLBA) is a new method for postoperative pain relief in patients undergoing abdominal surgery. Perioperative QLBA is effective, but it has not been compared with posterior quadratus lumborum block (QLB2). The present study aims to evaluate the postoperative pain of patients undergoing laparoscopic nephrectomy surgery with QLBA versus QLB2.Methods/designThis study is a randomised, prospective, parallel group, non-inferior trial. All patients undergoing laparoscopic nephrectomy surgery will be randomised 1:1 to the QLBA group or the QLB2 group with general anaesthesia. The objective of the trial is to evaluate the postoperative pain of patients undergoing laparoscopic nephrectomy surgery with QLBA (n=50) versus QLB2 (n=50). The primary outcome for this trial is the Visual Analogue Scale scores at rest and activity (dynamic pain scores are assessed with a cough or a trial to sit up in bed) 2 hours after surgery between patients who receive QLBA versus QLB2. The secondary objectives will be to compare (1) pain at rest and activity 0.5 hour, 2 hours, 24 hours, 48 hours after surgery; (2) the time spent on block operation; (3) the blocked dermatomal coverage 5 min and 15 min after block operation; (4) intraoperative opioid consumption; (5) types and doses of the rescue analgesic after surgery; (6) nausea and vomiting score within 24 hours after surgery; (7) time from the end of surgery to the first onset significant pain; (8) patient satisfaction score.DiscussionClinical experience has supported that QLB is a very effective postoperative analgesic method, and we will answer the following questions in this trial: Will both approaches have the same analgesic effect and duration? Will the QLBA have a non-inferior postoperative analgesic effect compared with QLB2 or the QLBA be able to prolong the duration of analgesia after surgery? The results of this study could have actual clinical applications that could help to reduce postoperative pain and shorten hospital stays.Ethics and disseminationThe study design was approved by the ethical committee of Beijing Chao-Yang Hospital, Beijing, China (2020-ke-321). The trial results will be published in peer-reviewed journals and at conferences.Trial registration numberChiCTR2000035354.

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Preemptive Analgesic Effect of Magnesium Sulfate on Postoperative Pain in Patients Undergoing Gastrectomy

Korean Journal of Anesthesiology ◽

10.4097/kjae.1999.36.5.856 ◽

1999 ◽

Vol 36 (5) ◽

pp. 856

Author(s):

Moon Soo Hur ◽

Kwang Jo Oh ◽

Seong Hoon Ko ◽

Young Jin Han ◽

Huhn Choe

Keyword(s):

Postoperative Pain ◽

Magnesium Sulfate ◽

Analgesic Effect

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Effects of 2% lidocaine hydrochloride solution as a coinduction agent with propofol on cardiopulmonary variables and administered propofol doses in healthy dogs premedicated with hydromorphone hydrochloride and acepromazine maleate

Journal of the American Veterinary Medical Association ◽

10.2460/javma.256.1.93 ◽

2020 ◽

Vol 256 (1) ◽

pp. 93-101

Author(s):

Callie E. Cazlan ◽

Bonnie L. Hay Kraus

Keyword(s):

Lidocaine Hydrochloride ◽

Healthy Dogs ◽

Hydrochloride Solution

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Intraoperative and Postoperative Anaesthetic and Analgesic Effect of Multipoint Transcutaneous Electrical Acupuncture Stimulation Combined with Sufentanil Anaesthesia in Patients Undergoing Supratentorial Craniotomy

Acupuncture in Medicine ◽

10.1136/acupmed-2014-010749 ◽

2015 ◽

Vol 33 (4) ◽

pp. 270-276 ◽

Cited By ~ 20

Author(s):

Xing Liu ◽

Shuqin Li ◽

Baoguo Wang ◽

Lixin An ◽

Xiujun Ren ◽

...

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Postoperative Pain ◽

Analgesic Effect ◽

Postoperative Recovery ◽

Tumour Resection ◽

Acupuncture Stimulation ◽

Supratentorial Craniotomy ◽

Electrical Acupuncture ◽

Registration Number

Objectives To investigate the anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture stimulation (TEAS) during supratentorial tumour resection for postoperative recovery and side effects. Methods In a blinded clinical trial, 92 patients scheduled for supratentorial craniotomy under general anaesthesia were randomly allocated into either a multipoint TEAS (n=46) or a sham TEAS group (n=46). All patients received total intravenous anaesthesia (TIVA) with propofol and sufentanil. The target concentration of sufentanil was adjusted and recorded according to mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS). Patients in the TEAS group received TEAS 30 min before anaesthesia induction and this was maintained throughout the operation at four pairs of acupuncture points. Postoperative pain, recovery and side effects were evaluated. Results Eighty-eight patients completed the study. Continuous monitoring of MAP, HR and BIS showed stable values with no significant differences between the two groups (p>0.05). Sufentanil target plasma concentration in TEAS patients was significantly lower at some time points during supratentorial craniotomy, and total sufentanil consumption was significantly higher in the sham group (p<0.05). Postoperative recovery and pain were significantly improved by TEAS (p<0.001), without the postoperative side effects. Conclusions Multipoint TEAS at both proximal and distal points combined with TIVA can significantly decrease intraoperative sufentanil requirements, increase pain relief on postoperative day 1 and improve postoperative recovery of patients during supratentorial tumour resection, with no significant increase of side effects. These findings suggest that multipoint TEAS may be clinically effective as an adjunct to analgesia in intraoperative anaesthesia and postoperative pain treatment and may speed recovery. Trial Registration Number Chinese Clinical Trial Registry (registration number ChiCTR-TRC-10001078).

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