scholarly journals Stiff-Person Syndrome Associated with Anti-Glutamic Acid Decarboxylase Autoimmune Encephalitis in a Young Woman: A Case Report

2020 ◽  
Vol 35 (4) ◽  
pp. 387 ◽  
Author(s):  
Gao Shanyu ◽  
Lu Jun ◽  
Zhao Chongbo
Keyword(s):  
Case Report ◽  
Glutamic Acid ◽  
Young Woman ◽  
Glutamic Acid Decarboxylase ◽  
Autoimmune Encephalitis ◽  
Acid Decarboxylase ◽  
Stiff Person Syndrome

scholarly journals Pediatric stiff-person syndrome with renal failure

2016 ◽  
Vol 7 (01) ◽  
pp. 147-149 ◽  
Author(s):  
M. Veerendra Kumar ◽  
P. Savida
Keyword(s):  
Renal Failure ◽  
Case Report ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Case Reports ◽  
Acid Decarboxylase ◽  
Stiff Person Syndrome

ABSTRACTStiff-person syndrome (SPS) is an autoimmune neuronitis with progressive myoclonus and stiffness. It is a rare but treatable disorder with few case reports in children. SPS is due to autoantibodies against the enzyme glutamic acid decarboxylase which is present in neuronal and nonneuronal tissues. This is the case report of an 8-year-old boy with clinical and investigational features suggestive of SPS with associated myoglobin-induced renal failure, who completely recovered with treatment.

scholarly journals Stiff Person Syndrome Associated with Compartment Syndrome

2019 ◽  
Vol 11 (2) ◽  
pp. 217-221
Author(s):  
Kok Pin Yong ◽  
Yew Long Lo
Keyword(s):  
Case Report ◽  
Glutamic Acid ◽  
Compartment Syndrome ◽  
Glutamic Acid Decarboxylase ◽  
Neurological Disorder ◽  
Medical Emergency ◽  
Acid Decarboxylase ◽  
Stiff Person Syndrome ◽  
First Case ◽  
Muscle Spasms

Stiff person syndrome (SPS) is a rare and disabling neurological disorder of autoimmune origin, characterized by progressive stiffness and muscle spasms affecting the axial and limb muscles, most frequently associated with antibodies against glutamic acid decarboxylase. We describe a patient who presented initially with compartment syndrome and was later diagnosed with SPS.This is the first case report of SPS possibly presenting initially with compartment syndrome. This case illustrates the importance of recognizing that patients with SPS may present with varied manifestations, including compartment syndrome, which by itself is a medical emergency.

scholarly journals Improvement of stiff-person syndrome symptoms in pregnancy

2020 ◽  
Vol 7 (3) ◽  
pp. e684 ◽  
Author(s):  
Megan E. Esch ◽  
Scott D. Newsome
Keyword(s):  
Glutamic Acid ◽  
Clinical Improvement ◽  
Glutamic Acid Decarboxylase ◽  
Clinical Symptoms ◽  
Acid Decarboxylase ◽  
Stiff Person Syndrome ◽  
Treatment Changes ◽  
Gad65 Antibody ◽  
Insight Into ◽  
In Pregnancy

ObjectiveTo describe 2 cases from a single academic institution of improvement in stiff-person syndrome (SPS) symptoms during pregnancy and to review the clinical outcomes of SPS in 6 additional pregnancies described in the literature.MethodsEvaluation of clinical symptoms and treatment changes of disease state during pregnancy.ResultsSeven patients with 9 pregnancies are described in women with a diagnosis of SPS. Six of 7 (86%) women were positive for glutamic acid decarboxylase (GAD65) antibody. In 5 of 9 (56%) pregnancies, symptomatic medications (antispasmodics) were significantly reduced with stabilization or improvement in symptoms through pregnancy. Nine live, healthy pregnancies resulted. All 7 (100%) women experienced worsening of symptoms after the birth of their children, and symptomatic therapies were resumed and/or increased.ConclusionsThe immune pathogenesis of SPS continues to be explored. Immunomodulatory shifts during pregnancy may influence changes of clinical SPS symptoms and provide insight into the unique pathogenesis of SPS. Some women with SPS may be able to reduce symptomatic medications related to clinical improvement during pregnancy. Women with SPS may safely carry pregnancies to term, delivering healthy and unaffected babies.

scholarly journals Autoimmune musicogenic epilepsy associated with anti‐glutamic acid decarboxylase antibodies and Stiff‐person syndrome

2019 ◽  
Vol 8 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Joana Jesus‐Ribeiro ◽  
Alireza Bozorgi ◽  
Modhi Alkhaldi ◽  
Mahmoud Shaqfeh ◽  
Guadalupe Fernandez‐Baca Vaca ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Stiff Person Syndrome ◽  
Glutamic Acid Decarboxylase Antibodies ◽  
Musicogenic Epilepsy

Cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies: a case report

2019 ◽  
Vol 40 (6) ◽  
pp. 1303-1306 ◽  
Author(s):  
Silvia Maria Villa ◽  
Alessandra Rufa ◽  
Alessandro Malandrini ◽  
Alfonso Cerase ◽  
Francesca Rosini ◽  
...  
Keyword(s):  
Case Report ◽  
Glutamic Acid ◽  
Cerebellar Ataxia ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Glutamic Acid Decarboxylase Antibodies
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