Amphotericin B Nasal Irrigation as an Adjuvant Therapy after Functional Endoscopic Sinus Surgery

AbstractBackgroundNasal irrigation is commonly performed in patients with chronic rhinosinusitis after functional endoscopic sinus surgery. This study systematically assessed the clinical efficacy of nasal irrigation from the medical literature.MethodsThe PubMed, Embase and Cochrane Central Register of Controlled Trials databases were searched using a comprehensive strategy, limited to English-language articles, published from October 1971 to March 2017, and comprising human subjects.ResultsA total of 824 trials were identified, 5 of which, involving 331 participants, were included in this systematic review. After selection, only three trials were eligible for inclusion in a meta-analysis. Nasal irrigation using normal saline and various solutions was found to be effective in reducing symptom scores and endoscopic scores for chronic rhinosinusitis patients after functional endoscopic sinus surgery. Comparison of outcome measures, such as eosinophil count reduction, revealed that various solutions are more effective than normal saline alone; however, no statistical significance was found in terms of reduced symptom or endoscopic scores.ConclusionBased on the current limited evidence, nasal irrigation is an effective therapy for chronic rhinosinusitis patients after functional endoscopic sinus surgery. However, when comparing various solutions with normal saline, no significant difference was found in symptom scores or endoscopic scores.

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Impact of Pulsatile Nasal Irrigation on the Prognosis of Functional Endoscopic Sinus Surgery

Yearbook of Otolaryngology-Head and Neck Surgery ◽

10.1016/s1041-892x(09)79352-7 ◽

2009 ◽

Vol 2009 ◽

pp. 210-211

Author(s):

R. Sindwani

Keyword(s):

Endoscopic Sinus Surgery ◽

Functional Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

Nasal Irrigation

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Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery

The Journal of Laryngology & Otology ◽

10.1017/s0022215119000446 ◽

2019 ◽

Vol 133 (4) ◽

pp. 300-308 ◽

Cited By ~ 2

Author(s):

F Mozzanica ◽

A Preti ◽

R Gera ◽

C Bulgheroni ◽

A Cardella ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Sodium Hyaluronate ◽

Functional Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

Double Blind ◽

Nasal Irrigation ◽

Post Operative Period ◽

Group 2 ◽

Group 1

AbstractObjectiveThere is a growing interest in sodium hyaluronate for the clinical management of patients who undergo functional endoscopic sinus surgery for chronic rhinosinusitis, because of the mucosal regenerative properties of this macromolecule. However, its role in post-operative care is still debated. This study aimed to evaluate the effect of sodium hyaluronate administered via nasal irrigation with saline, in the post-operative period, after functional endoscopic sinus surgery.MethodsA multicentric, prospective, randomised, double-blind, parallel group study was conducted on 56 consecutive patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without polyps. Group 1 received the standard therapy of normal saline; group 2 received saline plus sodium hyaluronate.ResultsBoth objective and subjective measurements, in terms of endoscopic appearance and patient-reported satisfaction, were significantly better in group 2 compared to group 1.ConclusionSodium hyaluronate may be a useful adjunct to nasal saline irrigation in the early post-operative period following functional endoscopic sinus surgery.

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