Repeated water avoidance stress causes resilience against colitis-induced behavioural changes in mice

2014 ◽  
Vol 2 (Suppl. 1) ◽  
pp. A1.7
Author(s):  
Ahmed M. Hassan
Keyword(s):  
Behavioural Changes

scholarly journals A systematic review of non-motor symptom evaluation in clinical trials for amyotrophic lateral sclerosis

2021 ◽  
Author(s):  
Emily Beswick ◽  
Deborah Forbes ◽  
Zack Hassan ◽  
Charis Wong ◽  
Judith Newton ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Amyotrophic Lateral Sclerosis ◽  
Sleep Disturbances ◽  
Neuropsychiatric Symptoms ◽  
Behavioural Change ◽  
Motor Symptom ◽  
Motor Symptoms ◽  
Behavioural Changes ◽  
Non Motor Symptoms ◽  
Lateral Sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is increasingly recognised as a multi-system disorder, presenting with common and impactful non-motor symptoms, such as neuropsychiatric symtpoms, cognitive and behavioural changes, pain, disordered sleep, fatigue and problematic saliva. Aim/hypothesis We aimed to systematically review 25 years of ALS clinical trials data to identify if non-motor features were evaluated, in addition to the traditional measures of motor functioning and survival, and where evaluated to describe the instruments used to assess. We hypothesised that assessment of non-motor symptoms has been largely neglected in trial design and not evaluated with ALS-suitable instruments. Methods We reviewed clinical trials of investigative medicinal products in ALS, since the licensing of riluzole in 1994. Trial registry databases including WHO International Trials Registry, European Clinical Trials Register, clinicaltrials.gov, and PubMed were systematically searched for Phase II, III or IV trials registered, completed or published between 01/01/1994 and 16/09/2020. No language restrictions were applied. Results 237 clinical trials, including over 29,222 participants, were investigated for their use of non-motor outcome measures. These trials evaluated neuropsychiatric symptoms (75, 32%), cognitive impairment (16, 6.8%), behavioural change (34, 14%), pain (55, 23%), sleep disturbances (12, 5%) and fatigue (18, 8%). Problematic saliva was assessed as part of composite ALS-FRS(R) scores in 184 trials (78%) but with no focus on this as an isolated symptom. 31 (13%) trials including 3585 participants did not include any assessment of non-motor symptoms. Conclusions Non-motor symptoms such as neuropsychiatric, cognitive and behavioural changes, pain, disordered sleep, fatigue, and problematic saliva have not been consistently evaluated in trials for people with ALS. Where evaluated, non-symptoms were primarily assessed using instruments and impairment thresholds that are not adapted for people with ALS. Future trials should include non-motor symptom assessments to evaluate the additional potential therapeutic benefit of candidate drugs. PROPSERO registration CRD42020223648.

scholarly journals Early behavioural changes in familial Alzheimer’s disease in the Dominantly Inherited Alzheimer Network

Brain ◽  
2015 ◽  
Vol 138 (4) ◽  
pp. 1036-1045 ◽  
Author(s):  
John M. Ringman ◽  
Li-Jung Liang ◽  
Yan Zhou ◽  
Sitaram Vangala ◽  
Edmond Teng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Familial Alzheimer’S Disease ◽  
Behavioural Changes ◽  
Familial Alzheimer's Disease

Behavioural changes in stabled horses given nontherapeutic levels of virginiamycin

1998 ◽  
Vol 30 (2) ◽  
pp. 139-143 ◽  
Author(s):  
K. G. JOHNSON ◽  
J. TYRRELL ◽  
J. B. ROWE ◽  
D. W. PETHICK
Keyword(s):  
Behavioural Changes

Abnormal behavioural changes associated with vasopressin-induced barrel rotations

1985 ◽  
Vol 326 (1) ◽  
pp. 65-70 ◽  
Author(s):  
R.J. Boakes ◽  
J.M. Ednie ◽  
J.A. Edwardson ◽  
A.B. Keith ◽  
A. Sahgal ◽  
...  
Keyword(s):  
Behavioural Changes
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