The influence of N-acetylcysteine on the cytotoxicity of single-walled carbon nanotubes in human lung carcinoma cells

2015 ◽  
Vol 3 (Suppl. 2) ◽  
pp. A5.5
Author(s):  
Nikola Jojić
Keyword(s):  
Carbon Nanotubes ◽  
Lung Carcinoma ◽  
Human Lung ◽  
Single Walled Carbon Nanotubes ◽  
Carcinoma Cells ◽  
Single Walled Carbon ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma ◽  
Walled Carbon Nanotubes

scholarly journals Cytotoxicity of single-walled carbon nanotubes to human lung carcinoma cells: The influence of N-acetylcysteine

2013 ◽  
Vol 21 (2) ◽  
pp. 59-61
Author(s):  
Nikola Jojic ◽  
Vesna Kojic ◽  
Danijela Kojic ◽  
Karmen Stankov ◽  
Gordana Bogdanovic
Keyword(s):  
Carbon Nanotubes ◽  
Lung Carcinoma ◽  
Human Lung ◽  
Single Walled Carbon Nanotubes ◽  
Carcinoma Cells ◽  
Lung Cells ◽  
Lung Carcinoma Cells ◽  
Low Concentrations ◽  
Human Lung Carcinoma ◽  
Walled Carbon Nanotubes

Background: Single-walled carbon nanotubes (SWCNTs) have been reported to induce cytotoxicity in different cell lines. Although the mechanisms underlying cytotoxicity are not fully understood, accumulation of reactive oxygen species (ROS) and oxidative damage is considered to be a likely contributing factor. Methods: Human lung carcinoma cells, A549, and human fetal lung fibroblasts, MRC-5 were used to assess the cytotoxicity of SWCNT in the presence and absence of a redox status regulator, N-acetylcysteine (NAC), via the MTT assay. Results: SWCNT induced a nearly three-fold greater loss of viability in A594 vs. MRC-5 cells at ?250 ?g/ml. SWCNT cytotoxicity at higher concentrations was similar for both cell lines, while NAC alone was non-toxic. The cytotoxicity of SWCNT (250 ?g/ml) in combination with NAC to A549 cells was significantly decreased at the lowest NAC concentration (1.5 ?g/ml), and was similar to NAC treatment alone at that concentration. Higher concentrations of NAC in combination with SWCNT (250 ?g/ml) resulted in increased cytotoxicity in both A549 and MRC-5 cells. Conclusion: A549 malignant lung cells are more susceptible to low concentrations of SWCNT vs. normal lung cells, and low concentrations of N-acetylcysteine appear to be cytoprotective, possibly due to its antioxidant properties.

scholarly journals Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

1991 ◽  
Vol 266 (28) ◽  
pp. 18771-18779
Author(s):  
M.H. Corjay ◽  
D.J. Dobrzanski ◽  
J.M. Way ◽  
J. Viallet ◽  
H. Shapira ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Receptor Subtypes ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma ◽  
Bombesin Receptor

Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells

2011 ◽  
Vol 25 (7) ◽  
pp. 1082-1086 ◽  
Author(s):  
Hye-Jin Boo ◽  
Jae-Hee Hyun ◽  
Sang-Cheol Kim ◽  
Jung-Il Kang ◽  
Min-Kyoung Kim ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
Undaria Pinnatifida ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma

PKCδ–iPLA2–PGE2–PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells

2015 ◽  
Vol 27 (3) ◽  
pp. 568-577 ◽  
Author(s):  
Daisuke Iitaka ◽  
Serisha Moodley ◽  
Hiroki Shimizu ◽  
Xiao-Hui Bai ◽  
Mingyao Liu
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Signaling Cascade ◽  
Lung Carcinoma Cells ◽  
Tnf Α ◽  
Human Lung Carcinoma

scholarly journals The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells

Oncogene ◽  
2008 ◽  
Vol 28 (3) ◽  
pp. 390-400 ◽  
Author(s):  
S Li ◽  
A Szymborski ◽  
M-J Miron ◽  
R Marcellus ◽  
O Binda ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
Growth Arrest ◽  
Carcinoma Cells ◽  
Mitotic Catastrophe ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma

chemosensitivity testing of human lung carcinoma cells

1987 ◽  
Vol 23 (11) ◽  
pp. 1739-1740
Author(s):  
S. Casillo ◽  
A. La Pera ◽  
F. Salvati ◽  
G. Storniello ◽  
A. Antilli
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Chemosensitivity Testing ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma

scholarly journals Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene in Curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells

2018 ◽  
Vol 19 (7) ◽  
pp. 1943 ◽  
Author(s):  
Miri Lee ◽  
Kyoung-Sook Kim ◽  
Abekura Fukushi ◽  
Dong-Hyun Kim ◽  
Cheorl-Ho Kim ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Transcriptional Activation ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Gd3 Synthase ◽  
Human Lung Carcinoma ◽  
I Gene
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