scholarly journals NemoMap: Improved Motif-centric Network Motif Discovery Algorithm

2018 ◽  
Vol 3 (5) ◽  
pp. 186-199 ◽  
Author(s):  
Tien Huynh ◽  
Somadina Mbadiwe ◽  
Wooyoung Kim
2017 ◽  
Author(s):  
Mitra Ansariola ◽  
Molly Megraw ◽  
David Koslicki

AbstractGenomic networks represent a complex map of molecular interactions which are descriptive of the biological processes occurring in living cells. Identifying the small over-represented circuitry patterns in these networks helps generate hypotheses about the functional basis of such complex processes. Network motif discovery is a systematic way of achieving this goal. However, a reliable network motif discovery outcome requires generating random background networks which are the result of a uniform and independent graph sampling method. To date, there has been no sound practical method to numerically evaluate whether any network motif discovery algorithm performs as intended—thus it was not possible to assess the validity of resulting network motifs. In this work, we present IndeCut, the first and only method that allows characterization of network motif finding algorithm performance on any network of interest. We demonstrate that it is critical to use IndeCut prior to running any network motif finder for two reasons. First, IndeCut estimates the minimally required number of samples that each network motif discovery tool needs in order to produce an outcome that is both reproducible and accurate. Second, IndeCut allows users to choose the most accurate network motif discovery tool for their network of interest among many available options. IndeCut is an open source software package and is available at https://github.com/megrawlab/IndeCut.


2017 ◽  
Vol 34 (9) ◽  
pp. 1514-1521 ◽  
Author(s):  
Mitra Ansariola ◽  
Molly Megraw ◽  
David Koslicki

2009 ◽  
Vol 84 (5) ◽  
pp. 385-395 ◽  
Author(s):  
Saeed Omidi ◽  
Falk Schreiber ◽  
Ali Masoudi-Nejad

Electronics ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 183
Author(s):  
Hangyu Hu ◽  
Mingda Wang ◽  
Mingyu Ouyang ◽  
Guangmin Hu

Network worms spread widely over the global network within a short time, which are increasingly becoming one of the most potential threats to network security. However, the performance of traditional packet-oriented signature-based methods is questionable in the face of unknown worms, while anomaly-based approaches often exhibit high false positive rates. It is a common scenario that the life cycle of network worms consists of the same four stages, in which the target discovery phase and the transferring phase have specific interactive patterns. To this end, we propose Network Flow Connectivity Graph (NFCG) for identifying network worm victims. We model the flow-level interactions as graph and then identify sets of frequently occurring motifs related to network worms through Cascading Motif Discovery algorithm. In particular, a cascading motif is jointly extracted from graph target discovery phase and transferring phase. If a cascading motif exists in a connected behavior graph of one host, the host would be identified as a suspicious worm victim; the excess amount of suspicious network worm victims is used to reveal the outbreak of network worms. The simulated experiments show that our proposed method is effective and efficient in network worm victims’ identification and helpful for improving network security.


IEEE Access ◽  
2018 ◽  
Vol 6 ◽  
pp. 14151-14158 ◽  
Author(s):  
Jiawei Luo ◽  
Lv Ding ◽  
Cheng Liang ◽  
Nguyen Hoang Tu

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