scholarly journals Diagnosis dan Tatalaksana Penyakit Paru Nontuberculous mycobacteria

2018 ◽  
Vol 7 ◽  
pp. 141
Author(s):  
Linda Ratna Juita ◽  
Fauzar Fauzar
Keyword(s):  
Nontuberculous Mycobacteria ◽  
Atypical Mycobacteria ◽  
Mycobacteria Other Than Tuberculosis

Nontuberculous mycobacteria (NTM) juga dikenal dengan atypical mycobacteria atau mycobacteria other than tuberculosis merupakan organisme patogen oportunistik yang dapat menyebabkan penyakit paru progresif. Spesies yang paling banyak ditemukan adalah Mycobacteria avium complex (MAC), M. kansasii, M. malmose, dan M. xenopi. Diagnosis penyakit paru NTM berdasarkan manisfestasi klinis dan radiologis (fibrokavitas dan bronkiektasis nodular). Kultur merupakan standar emas untuk konfirmasi laboratorium dari NTM dan diperlukan untuk identifikasi genotipe dan drug suscebtibility test (DST). Antibiotik golongan makrolida seperti azitromisin dan klaritomisin merupakan terapi dasar untuk infeksi paru NTM. Rekomendasi menganjurkan terapi kombinasi makrolida (azitromisin atau klaritromisin), rifampin atau rifabutin, dan etambutol dengan atau tanpa aminoglikosida intravena. Terapi medikamentosa dilakukan secara kontiniu diberikan minimal selama 12 bulan setelah didapatkan biakan sputum negatif.

Mycobacteriosis as a Healthcare-Associated Infection: A Review of Epidemiologic Studies

2020 ◽  
pp. 37-41
Author(s):  
IV Petrov ◽  
TKh Amirova ◽  
LV Petrova ◽  
FS Petrova
Keyword(s):  
Skin Diseases ◽  
Nontuberculous Mycobacteria ◽  
Clinical Manifestations ◽  
Mycobacterial Infection ◽  
Epidemiologic Studies ◽  
Health Facilities ◽  
Water Supply Systems ◽  
Healthcare Associated Infections ◽  
Healthcare Associated Infection ◽  
Healthcare Associated

Introduction: Healthcare-associated infections are of great socio-economic importance and are characterized by a large number of different pathogens. Nontuberculous mycobacteria are ubiquitous microorganisms that can circulate in a medical organization. The purpose of this review of epidemiologic studies was to establish the main features of mycobacteriosis as a healthcare-associated infection, taking into account the significance of the results and the compliance of the reviewed studies with the criteria of evidence-based medicine. Methods: We did a key word search for “nontuberculous mycobacteria”, “healthcare-associated infections”, and “mycobacteriosis” in several electronic bibliographic databases including Web of Science, PubMed, eLIBRARY, and ResearchGate and selected 127 out of 342 search results. Having analyzed the selected articles, we decided to include 34 of them in this study according to the topic of work. We established that nontuberculous mycobacteria can be found in various objects of health facilities, e.g. water supply systems, medical products and equipment. We also found that mycobacterial infection of nosocomial etiology could have various clinical manifestations (arthritis, keratitis, circulatory and skin diseases, etc.) determined by various aspects, such as heterogeneity of the group of nontuberculous mycobacteria, portals of entry (surgical procedures on various organs and systems of the human body, etc.), pathways of exposure and transmission factors. Resistance of nontuberculous mycobacteria to a number of disinfectants is a special question defining the importance of profound research in terms of ensuring sanitary and anti-epidemic (disinfection) safety within health facilities. Conclusions: Our findings indicate that mycobacterial infection can be considered as a healthcare-associated infection requiring an in-depth assessment from various perspectives including a microbiological monitoring of medical objects, statistical accounting of nosocomial infections, and clinical alertness in the diagnosis of mycobacteriosis by attending physicians and bacteriologists, etc.

scholarly journals Current trends in nontuberculous mycobacteria infections in Canadian children: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study

2010 ◽  
Vol 15 (5) ◽  
pp. 276-282 ◽  
Author(s):  
Anne Pham-Huy ◽  
Joan L Robinson ◽  
Bruce Tapiéro ◽  
Chantal Bernard ◽  
Sam Daniel ◽  
...  
Keyword(s):  
Nontuberculous Mycobacteria ◽  
Collaborative Network ◽  
Current Trends
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