HOW SENTINEL LYMPH NODE COULD SUPPORT LESS RADICAL SURGERY IN THE MANAGEMENT OF EARLY STAGE CERVICAL CANCER?

2016 ◽  
Author(s):  
Ioanna Koutroumpa
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Radical Surgery ◽  
Early Stage ◽  
Early Stage Cervical Cancer

Pre-operative surgical algorithm: sentinel lymph node biopsy as predictor of parametrial involvement in early-stage cervical cancer

2020 ◽  
Vol 30 (9) ◽  
pp. 1317-1325 ◽  
Author(s):  
Vincent Balaya ◽  
Arnaud Bresset ◽  
Benedetta Guani ◽  
Louise Benoit ◽  
Laurent Magaud ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Radical Hysterectomy ◽  
Radical Surgery ◽  
Early Stage ◽  
Low Risk ◽  
Node Biopsy ◽  
Parametrial Involvement ◽  
Early Stage Cervical Cancer

IntroductionRadical hysterectomy is the gold standard in the management of early-stage cervical cancer. Parametrectomy aims to remove occult disease but is associated with significant surgical morbidity. Avoiding unnecessary parametrectomy in a subset of patients at low risk of parametrial involvement may decrease the incidence of such morbidity. The purpose of this study was to identify patients at low risk of parametrial involvement in early-stage cervical cancer potentially eligible for less radical surgery based on pre-operative criteria and sentinel lymph node (SLN) status.MethodsWe performed an ancillary analysis of data from two prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I and II). Patients with International Federation of Gynecology and Obstetrics (FIGO) IA–IIA cervical cancer who underwent primary radical surgery and bilateral SLN mapping were identified between 2005 and 2012 from 25 French oncologic centers. Patients who underwent pre-operative brachytherapy or did not undergo radical surgery (simple trachelectomy, simple hysterectomy, or lymph node staging only) were excluded.ResultsOf 174 patients who fullfiled the inclusion criteria, 9 patients (5.2%) had parametrial involvement and 24 patients (13.8%) had positive SLN. Most patients had 2018 FIGO stage IB1 disease (86.1%) and squamous cell carcinomas (68.9%). Parametrial involvement was significantly associated with tumor size ≥20 mm on pelvic magnetic resonance imaging (MRI) (adjusted odds ratio (ORa) 9.30, 95% CI 1.71 to 50.57, p=0.01) and micrometastic or macrometastatic SLN (ORa 8.98, 95% CI 1.59 to 50.84, p=0.01). Of 114 patients with tumors <20 mm on pre-operative MRI and negative SLN after ultrastaging, only one patient had parametrial involvement (0.9%). By triaging patients with both of these criteria in a two-step surgical procedure, unjustified and contra-indicated radical hysterectomy would have been avoided in 65.5% and 8.6% of cases, respectively.ConclusionsLess radical surgery may be an option for patients with bilateral negative SLN after ultrastaging and tumors <20 mm. SLN status should be integrated into the decision-making process for tailored surgery in early-stage cervical cancer.

Application and outcomes of sentinel lymph node biopsy in early-stage cervical cancer

2020 ◽  
Vol 159 ◽  
pp. 31
Author(s):  
M.E. Byrne ◽  
D. Nasioudis ◽  
A.G. Roy ◽  
E.M. Ko ◽  
A.F. Haggerty ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Early Stage ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Early Stage Cervical Cancer

Surgical morbidity associated with learning curve of sentinel lymph node technique in early stage cervical cancer treatment

2019 ◽  
Vol 154 ◽  
pp. 141 ◽  
Author(s):  
G. Accorsi ◽  
R. Reis ◽  
R. Schmidt ◽  
L. Nobrega ◽  
A.C.M. Beolchi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Learning Curve ◽  
Cancer Treatment ◽  
Early Stage ◽  
Surgical Morbidity ◽  
Early Stage Cervical Cancer

Sentinel lymph node detection using methylene blue in patients with early stage cervical cancer

2007 ◽  
Vol 106 (1) ◽  
pp. 147-152 ◽  
Author(s):  
Song-Hua Yuan ◽  
Ying Xiong ◽  
Mei Wei ◽  
Xiao-Jian Yan ◽  
Hui-Zhong Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Methylene Blue ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Early Stage ◽  
Sentinel Lymph Node Detection ◽  
Early Stage Cervical Cancer
Sign in / Sign up

Export Citation Format

Share Document