Triple negative invasive breast carcinomas with comedo necrosis have a better prognosis than the majority of other triple negative tumours

2016 ◽  
Author(s):  
Taneisha McFarlane
Keyword(s):  
Triple Negative ◽  
Breast Carcinomas ◽  
Invasive Breast Carcinomas

scholarly journals Axl receptor tyrosine kinase expression in breast cancer

2014 ◽  
Vol 67 (8) ◽  
pp. 690-696 ◽  
Author(s):  
Timothy M D'Alfonso ◽  
Jeffrey Hannah ◽  
Zhengming Chen ◽  
Yifang Liu ◽  
Pengbo Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Breast Carcinomas ◽  
Invasive Breast Carcinomas

AimsTriple-negative breast cancer comprises a clinically aggressive group of invasive carcinomas. We examined a published gene expression screen of a panel of breast cancer cell lines to identify a potential triple-negative breast cancer-specific gene signature, and attempted to verify our findings by performing immunohistochemical analysis on tissue microarrays containing a large cohort of invasive breast carcinomas.MethodsThe microarray dataset for a panel of human breast cancer cell lines was interrogated for triple-negative breast cancer-specific genes. Membranous immunohistochemical expression of the protein product of the AXL gene was assessed semiquantitatively in 569 invasive breast carcinomas grouped according to molecular subgroup by immunohistochemistry.ResultsAXL was significantly upregulated in triple-negative/basal B cell lines compared with luminal or basal A cell lines. No significant difference was observed in the level of immunohistochemical expression of Axl protein between triple-negative breast cancers and other molecular subgroups (p=0.257). Axl expression was significantly associated with lymphovascular invasion (LVI) in all subgroups combined (p=0.033), and within the luminal A (p=0.002) and triple-negative breast cancer subgroups (p=0.026).ConclusionsDespite preferential upregulation of AXL in triple-negative/basal B cell lines, analysis of Axl protein expression in a large series of patients’ breast tumours revealed no association between Axl expression and triple-negative breast cancer or other subtype. The association of Axl expression with LVI supports previous work that implicates Axl as a promoter of invasiveness in breast cancer cell lines. Further studies are necessary to explore whether Axl expression of individual breast cancer tumours can be clinically useful.

Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior

Apmis ◽  
2011 ◽  
Vol 120 (2) ◽  
pp. 92-100 ◽  
Author(s):  
IRINI THEOHARI ◽  
IOANNA GIANNOPOULOU ◽  
CHRISTINA MAGKOU ◽  
ALEXANDROS NOMIKOS ◽  
SAVVAS MELISSARIS ◽  
...  
Keyword(s):  
Differential Effect ◽  
Breast Carcinomas ◽  
Invasive Breast Carcinomas
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