SEVERE ACUTE RESPIRATORY INFECTIONS CAUSED BY INFLUENZA A (H1N1)PDM09 IN A PEDIATRIC INTENSIVE CARE UNIT DURING THE 2015 –16 SEASON

2016 ◽  
Author(s):  
BOUZIRI ASMA
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Influenza A ◽  
Respiratory Infections ◽  
Pediatric Intensive Care ◽  
Acute Respiratory Infections ◽  
Influenza A H1n1 ◽  
Severe Acute Respiratory Infections

The Resource Burden of Infections With Rhinovirus/Enterovirus, Influenza, and Respiratory Syncytial Virus in Children

2018 ◽  
Vol 58 (2) ◽  
pp. 177-184 ◽  
Author(s):  
Jenna Fine ◽  
Amelia Bray-Aschenbrenner ◽  
Howard Williams ◽  
Paula Buchanan ◽  
Jason Werner
Keyword(s):  
Intensive Care Unit ◽  
Emergency Department ◽  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Pediatric Intensive Care Unit ◽  
Influenza A ◽  
Pediatric Intensive Care ◽  
Billing Data ◽  
Emergency Department Care ◽  
Syncytial Virus

We reviewed the resource utilization of patients with human rhinovirus/enterovirus (HRV/ENT), influenza A/B (FLU), or respiratory syncytial virus (RSV). A total of 2013 patients with nasopharyngeal swabs positive for HRV/ENT, RSV, or FLU were included. Records were reviewed for respiratory support, vascular access procedures, emergency department care only versus admission versus pediatric intensive care unit (PICU) care, antibiotics, length of stay, and billing data. Of the 2013 subjects, 1251 tested positive for HRV/ENT, 558 for RSV, and 204 for FLU. Fewer HRV/ENT patients were discharged from the emergency department ( P < .001); and they were more likely to be admitted to the pediatric intensive care unit ( P < .001). HRV/ENT and RSV patients were more likely to require invasive procedures ( P = .01). Median hospital costs for HRV/ENT patients were more than twice that of FLU patients ( P < .001). HRV/ENT infection in pediatric patients poses a significant resource and cost burden, even when compared with other organisms.

Influenza A (pH1N1) infection in children admitted to a pediatric intensive care unit: Differences with other respiratory viruses*

2011 ◽  
Vol 12 (3) ◽  
pp. e136-e140 ◽  
Author(s):  
Jorge S. Sasbón ◽  
Mónica A. Centeno ◽  
Mauro D. García ◽  
Nancy B. Boada ◽  
Bettina E. Lattini ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Influenza A ◽  
Pediatric Intensive Care ◽  
Respiratory Viruses

scholarly journals Respiratory microbes detected in hospitalized adults with acute respiratory infections: associations between influenza A(H1N1)pdm09 virus and intensive care unit admission or fatal outcome in Vietnam (2015–2017)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Phuong Thai Truong ◽  
Shinji Saito ◽  
Ikuyo Takayama ◽  
Hiroyuki Furuya ◽  
Binh Gia Nguyen ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza A ◽  
Respiratory Infections ◽  
Fatal Outcome ◽  
H3n2 Virus ◽  
Significance Level ◽  
Icu Admission ◽  
Pdm09 Virus ◽  
Influenza A H1n1

Abstract Background Acute respiratory tract infection (ARI) is a leading cause of hospitalization, morbidity, and mortality worldwide. Respiratory microbes that were simultaneously detected in the respiratory tracts of hospitalized adult ARI patients were investigated. Associations between influenza A(H1N1)pdm09 virus (H1N1pdm) detection and intensive care unit (ICU) admission or fatal outcome were determined. Methods This prospective observational study was conducted between September 2015 and June 2017 at Bach Mai Hospital, Hanoi, Vietnam. Inclusion criteria were hospitalized patients aged ≥15 years; one or more of symptoms including shortness of breath, sore throat, runny nose, headache, and muscle pain/arthralgia in addition to cough and fever > 37.5 °C; and ≤ 10 days from the onset of symptoms. Twenty-two viruses, 11 bacteria, and one fungus in airway specimens were examined using a commercial multiplex real-time PCR assay. Associations between H1N1pdm detection and ICU admission or fatal outcome were investigated by univariate and multivariate logistic regression analyses. Results The total of 269 patients (57.6% male; median age, 51 years) included 69 ICU patients. One or more microbes were detected in the airways of 214 patients (79.6%). Single and multiple microbes were detected in 41.3 and 38.3% of patients, respectively. Influenza A(H3N2) virus was the most frequently detected (35 cases; 13.0%), followed by H1N1pdm (29 cases; 10.8%). Hematological disease was associated with ICU admission (p < 0.001) and fatal outcomes (p < 0.001) using the corrected significance level (p = 0.0033). Sex, age, duration from onset to sampling, or number of detected microbes were not significantly associated with ICU admission or fatal outcomes. H1N1pdm detection was associated with ICU admission (odds ratio [OR] 3.911; 95% confidence interval [CI] 1.671–9.154) and fatal outcome (OR 5.496; 95% CI 1.814–16.653) after adjusting for the confounding factors of comorbidities, bacteria/Pneumocystis jirovecii co-detection, and age. Conclusions H1N1pdm was associated with severe morbidity and death in adult patients hospitalized with respiratory symptoms. The diagnosis of subtype of influenza virus may be epidemiologically important.

scholarly journals Rescue of four pediatric patients with severe influenza A (H3N2) in Weifang, China

2018 ◽  
Vol 46 (11) ◽  
pp. 4800-4805 ◽  
Author(s):  
Tianhua Li ◽  
Ningning Qi ◽  
Xiaona Gao ◽  
Haili Yu
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Influenza A ◽  
Muscular Atrophy ◽  
Antiviral Treatment ◽  
Clinical Manifestations ◽  
Pediatric Intensive Care ◽  
High Dose ◽  
Severe Influenza

In this report, we summarize our experience of rescuing four children with severe type A H3N2 influenza from January to February 2017 in Weifang People’s Hospital, Shandong Province, China for reference in clinical treatment. Two boys and two girls, ranging in age from 3 months to 6 years, with fever, cough, and asthma, were admitted to the pediatric intensive care unit. All children had severe pulmonary infection with respiratory distress. Three children had myocardial damage, two had liver damage, and one had encephalitis. One child had a history of bronchial asthma and one had severe spinal muscular atrophy. After all four children were admitted to the pediatric intensive care unit, they were provided active and effective organ function support and ventilator-assisted respiration. They were treated with gamma globulin, methylprednisolone, and antibiotics. Three children were treated with anti-influenza drugs and recovered from influenza; one child died even before antiviral treatment intervention on the first day. Definite diagnosis of the cases was through clinical manifestations, supplemented by laboratory tests, such as influenza virus H3N2 rapid antigen detection and nucleic acid detection. Early antiviral therapy, high-dose glucocorticoids and immunoglobulins, and systemic comprehensive rescue might be important for rescuing children with severe influenza A (H3N2).

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