Background:
The development of modern medical and pharmaceutical science
has garnered lots of attention due to the development of targeted therapy and precision
medicine. The current focus of the researchers is on developing strategies which provide
the maximum therapeutic benefits with minimal adverse effects. In this scenario,
nanostructured lipid carriers (NLC) have gained prominence because of their ability to
improve the therapeutic properties of the drugs.
Objective:
In this review, we focus on some of the important methods involved in the
preparation and characterization of the NLCs. We also discuss the application of NLC as
a drug delivery system through different routes of administration and its role in overcoming
the physiological and anatomical barriers.
Methods:
The literature was collected from different scientific browsers like sciencedirect,
google scholar, pubmed and a total of 155 articles were read and analysed for the
content.
Results:
The NLC improve the solubility and bioavailability of the drug, prolong the release
and residence time and delay clearance. They also protect the drugs from enzymatic degradation
and allow them to pass through different anatomical and physiological barriers.
Conclusion:
Though the use of NLCs has been reported across different therapeutic indications
through various routes of administration, this success at the laboratory level has
not gone to the next stage. One of the reasons for the failure of NLC formulations to progress
to the next level could be due to toxicity caused by the accumulation of NLCs in
organs. Hence, in order to utilize this strategy to its maximum potential, further research
is inevitable.
Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery
