Bioanalytical Method Development and Validation for Determination of Dibromophenazine in Rat Plasma and Its Application to Pharmacokinetic Study

2016 ◽  
Author(s):  
Ing-orn Prasanchaimontri
Keyword(s):  
Pharmacokinetic Study ◽  
Method Development ◽  
Rat Plasma ◽  
Bioanalytical Method ◽  
Method Development And Validation ◽  
Development And Validation

LC–MS/MS method development and validation for the determination of polymyxins and vancomycin in rat plasma

2010 ◽  
Vol 878 (28) ◽  
pp. 2831-2838 ◽  
Author(s):  
Chang Cheng ◽  
Shaorong Liu ◽  
Deqing Xiao ◽  
John Hollembaek ◽  
Lili Yao ◽  
...  
Keyword(s):  
Method Development ◽  
Rat Plasma ◽  
Method Development And Validation ◽  
Development And Validation

Bioanalytical method development and validation of UV spectrophotometric method for estimation of Bumetanide spiked in human urine

2021 ◽  
Vol 11 (2) ◽  
pp. 241-248
Author(s):  
Bhavya sri Khagga ◽  
Kavya.Parelli
Keyword(s):  
Spectrophotometric Method ◽  
Human Urine ◽  
Method Development ◽  
Uv Detector ◽  
Bioanalytical Method ◽  
Method Development And Validation ◽  
Uv Visible ◽  
Development And Validation ◽  
Spiked Human Urine

The main purpose of this study was to develop a simple precise, rapid and accurate UV-visible spectrophotometric method for determination of Bumetanide in spiked human urine by extracting the Bumetanide from spiked human urine using ethyl acetate after extraction it was scanned between 200-400nm by using UV detector and its absorbance maxima was found to be 222nm.The calibration curve was linear in the range of 1-17 µg/ml. .the recovery and assay studies of bumetanide were within 93-94.85% indicating that the proposed method can be estimation of bumetanide.

scholarly journals HPLC-MS method development and validation for simultaneous quantitation of GZK-111 and CPG compounds in rat plasma

2020 ◽  
pp. 28-36
Author(s):  
A. L. Podolko ◽  
P. O. Bochkov ◽  
G. B. Kolyvanov ◽  
A. A. Litvin ◽  
O. G. Gribakina ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Lower Limit ◽  
High Performance ◽  
Method Development ◽  
Limit Of Detection ◽  
Rat Plasma ◽  
Rat Blood ◽  
Method Development And Validation ◽  
Development And Validation

The technique of quantitative determination of GZK-111 and CPG compounds in rat blood plasma has been developed. The analysis was carried out using the combined method of high-performance liquid chromatography with mass spectrometric detection. The method was linear in the concentration range of 25-1000 ng/ml for both compounds. Percentage of GZK-111 extraction from rat blood plasma was 57.8 %. The lower limit of detection for GZK- 111 compound was 25 ng/ml. Percentage of extraction of CPG compound was 42.5 %. The lower limit of detection of CPG compound was also 25 ng/ml.

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