Association between cytokine gene polymorphisms and cognitive functions in relapsing-remitting multiple sclerosis

2017 ◽  
Author(s):  
Georgi S. Slavov
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Functions ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Relapsing Remitting ◽  
Cytokine Gene Polymorphisms ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Profile of cytokine gene polymorphisms in Iranian multiple sclerosis patients

2007 ◽  
Vol 13 (2) ◽  
pp. 253-255 ◽  
Author(s):  
A Amirzargar ◽  
F Khosravi ◽  
S Dianat ◽  
F Hushmand ◽  
P Maryousef ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Immune Mediated ◽  
Tnf Α ◽  
Relapsing Remitting ◽  
Cytokine Gene Polymorphisms ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

Background Cytokine gene polymorphisms have been extensively studied in association with different diseases. The role of cytokine gene polymorphisms in multiple sclerosis (MS), as a chronic immune-mediated neurodegenerative disease, has been previously reported. Materials and methods DNA samples were collected from 44 patients with relapsing-remitting multiple sclerosis (RRMS) and 140 unrelated healthy subjects. All participants in this study were matched for ethnicity. Cytokine gene SNPs were determined using the PCR-SSP method. Results and discussion We found no significant differences between MS patients and controls in most of the studied cytokine genes. Remarkable results were obtained for IL-2 GG —330 genotype (P = 0.06), IL-6 C —174 allele (P = 0.06), CG and GG genotypes (P < 0.001), and GG (P = 0.02) and CG (P < 0.001) haplotypes, and TNF-α A —238 allele (P < 0.001), GG (P = 0.003) and GA (P < 0.001) haplotypes. These results suggest that polymorphic variations of these pro-inflammatory cytokines play an important role in susceptibility to MS. Multiple Sclerosis 2007; 13: 253–255. http://msj.sagepub.com

Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population

2017 ◽  
Vol 128 (6) ◽  
pp. 505-511 ◽  
Author(s):  
Rasoul Abdollahzadeh ◽  
Parisa Moradi Pordanjani ◽  
Farideh Rahmani ◽  
Fatemeh Mashayekhi ◽  
Asaad Azarnezhad ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis
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