Functional mode of action of ASP5736, a selective 5-HT5A receptor antagonist for treatment of cognitive dysfunction in schizophrenia

2018 ◽  
Author(s):  
Torgny H. Svensson
Keyword(s):  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
Mode Of Action ◽  
Functional Mode

Functional mode of action of ASP5736, a selective 5-HT5A receptor antagonist for treatment of cognitive dysfunction in schizophrenia

2019 ◽  
Vol 29 ◽  
pp. S414-S415
Author(s):  
T.H. Svensson ◽  
M. Yamazaki ◽  
N. Yamamoto ◽  
J. Yarimizu ◽  
M. Okabe ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
Mode Of Action ◽  
Functional Mode

P1-235: Effects of the novel histamine H3 receptor antagonist S 38093 in a non-human primate model of cognitive dysfunction

2009 ◽  
Vol 5 (4S_Part_8) ◽  
pp. P245-P245
Author(s):  
Jay S. Schneider ◽  
Emmanuel Decamp ◽  
Michael Hill ◽  
Erwan Bezard ◽  
Alan Crossman ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
The Novel ◽  
Primate Model ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Primate ◽  
Histamine H3

scholarly journals A peripherally restricted P2Y 12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism

2014 ◽  
Vol 1 ◽  
pp. 1202-1212 ◽  
Author(s):  
David A. Brott ◽  
Håkan A.S. Andersson ◽  
Jane Stewart ◽  
Lorna Ewart ◽  
Greg Christoph ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Mode Of Action ◽  
Rat Tumor

Suvorexant: something new for sleep?

2014 ◽  
Vol 27 (1) ◽  
pp. 53-55 ◽  
Author(s):  
Abhishek Reddy ◽  
Sowmya C Puvvada ◽  
Satyanarayana Kommisetti ◽  
Rif S. El-Mallakh ◽  
Steven Lippmann
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
Drug Dependence ◽  
Side Effect ◽  
Good Choice ◽  
Clinical Use ◽  
Apparent Lack ◽  
Considerable Benefit

Orexin, also called hypocretin, is a neuropeptide that acts on central nervous system receptors to promote arousal. Suvorexant, its receptor antagonist, generates interest as a medication to treat insomnia. Suvorexant helps in decreasing wakefulness by counteracting orexin activity. Its low side effect potential may offer considerable benefit. Compared with other sleep aids, diminished drowsiness and less cognitive dysfunction is an advantage. Now approved for clinical use, an apparent lack of rebound insomnia or drug dependence potential might make suvorexant a good choice pharmacotherapy for patients with insomnia.

P4-342: Effects of the novel histamine H3 receptor antagonist S 38093 in a non-human primate model of cognitive dysfunction

2009 ◽  
Vol 5 (4S_Part_17) ◽  
pp. e31-e31
Author(s):  
Jay S. Schneider ◽  
Emmanuel Decamp ◽  
Michael Hill ◽  
Erwan Bezard ◽  
Alan Crossman ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
The Novel ◽  
Primate Model ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Primate ◽  
Histamine H3
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